N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies
Identifieur interne : 000773 ( Pmc/Checkpoint ); précédent : 000772; suivant : 000774N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies
Auteurs : Pradeep Kumar [Inde] ; Balasubramanian Narasimhan [Inde] ; Kalavathy Ramasamy ; Vasudevan Mani ; Rakesh Kumar Mishra ; Abu Bakar Abdul Majeed ; Erik De Clercq [Belgique]Source :
- Monatshefte Fur Chemie [ 0026-9247 ] ; 2012.
Abstract
A variety of
Url:
DOI: 10.1007/s00706-012-0877-3
PubMed: NONE
PubMed Central: 7087754
Affiliations:
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last="Narasimhan">Balasubramanian Narasimhan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.411524.7</institution-id><institution-id institution-id-type="ISNI">0000000417902262</institution-id><institution>Faculty of Pharmaceutical Sciences,</institution><institution>Maharshi Dayanand University,</institution></institution-wrap>Rohtak, 124001 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Rohtak</wicri:regionArea></affiliation></author><author><name sortKey="Ramasamy, Kalavathy" sort="Ramasamy, Kalavathy" uniqKey="Ramasamy K" first="Kalavathy" last="Ramasamy">Kalavathy Ramasamy</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</nlm:aff><wicri:noCountry code="subfield">Selangor Malaysia</wicri:noCountry></affiliation></author><author><name sortKey="Mani, Vasudevan" sort="Mani, Vasudevan" uniqKey="Mani V" first="Vasudevan" last="Mani">Vasudevan Mani</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</nlm:aff><wicri:noCountry code="subfield">Selangor Malaysia</wicri:noCountry></affiliation></author><author><name sortKey="Mishra, Rakesh Kumar" sort="Mishra, Rakesh Kumar" uniqKey="Mishra 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type="city">Louvain</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7087754</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087754</idno><idno type="RBID">PMC:7087754</idno><idno type="doi">10.1007/s00706-012-0877-3</idno><idno type="pmid">NONE</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000307</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000307</idno><idno type="wicri:Area/Pmc/Curation">000307</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000307</idno><idno type="wicri:Area/Pmc/Checkpoint">000773</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000773</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>N</italic>′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies</title><author><name sortKey="Kumar, Pradeep" sort="Kumar, Pradeep" uniqKey="Kumar P" first="Pradeep" last="Kumar">Pradeep Kumar</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.411524.7</institution-id><institution-id institution-id-type="ISNI">0000000417902262</institution-id><institution>Faculty of Pharmaceutical Sciences,</institution><institution>Maharshi Dayanand University,</institution></institution-wrap>Rohtak, 124001 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Rohtak</wicri:regionArea></affiliation></author><author><name sortKey="Narasimhan, Balasubramanian" sort="Narasimhan, Balasubramanian" uniqKey="Narasimhan B" first="Balasubramanian" last="Narasimhan">Balasubramanian Narasimhan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.411524.7</institution-id><institution-id institution-id-type="ISNI">0000000417902262</institution-id><institution>Faculty of Pharmaceutical Sciences,</institution><institution>Maharshi Dayanand University,</institution></institution-wrap>Rohtak, 124001 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Rohtak</wicri:regionArea></affiliation></author><author><name sortKey="Ramasamy, Kalavathy" sort="Ramasamy, Kalavathy" uniqKey="Ramasamy K" first="Kalavathy" last="Ramasamy">Kalavathy Ramasamy</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</nlm:aff><wicri:noCountry code="subfield">Selangor Malaysia</wicri:noCountry></affiliation></author><author><name sortKey="Mani, Vasudevan" sort="Mani, Vasudevan" uniqKey="Mani V" first="Vasudevan" last="Mani">Vasudevan Mani</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</nlm:aff><wicri:noCountry code="subfield">Selangor Malaysia</wicri:noCountry></affiliation></author><author><name sortKey="Mishra, Rakesh Kumar" sort="Mishra, Rakesh Kumar" uniqKey="Mishra R" first="Rakesh Kumar" last="Mishra">Rakesh Kumar Mishra</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</nlm:aff><wicri:noCountry code="subfield">Selangor Malaysia</wicri:noCountry></affiliation></author><author><name sortKey="Majeed, Abu Bakar Abdul" sort="Majeed, Abu Bakar Abdul" uniqKey="Majeed A" first="Abu Bakar Abdul" last="Majeed">Abu Bakar Abdul Majeed</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</nlm:aff><wicri:noCountry code="subfield">Selangor Malaysia</wicri:noCountry></affiliation></author><author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name><affiliation wicri:level="3"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415751.3</institution-id><institution>Laboratory of Virology and Chemotherapy,</institution><institution>Rega Institute for Medical Research,</institution></institution-wrap>Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author></analytic><series><title level="j">Monatshefte Fur Chemie</title><idno type="ISSN">0026-9247</idno><idno type="eISSN">1434-4475</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Abstract</title><p>A variety of <italic>N</italic>′-[4-[(substituted imino)methyl]benzylidene]-substituted benzohydrazides have been synthesized and evaluated for antimicrobial and anticancer potential. Results from testing of antimicrobial activity indicated the most potent antimicrobial agents had p<italic>MIC</italic><sub>am</sub> = 1.51. The synthesized compounds were bacteriostatic and fungistatic in action. Results from evaluation of antiviral activity indicated that none of the synthesized hydrazide derivatives inhibited viral replication at sub-toxic concentrations. Results from anti-HIV screening against HIV-2 strain ROD indicated that one compound was more potent (<italic>IC</italic><sub>50</sub> ≥ 1 μg/cm<sup>3</sup>) than the standard drug nevirapine (<italic>IC</italic><sub>50</sub> ≥ 4 μg/cm<sup>3</sup>) and another was equipotent (<italic>IC</italic><sub>50</sub> ≥ 4 μg/cm<sup>3</sup>). The most effective anticancer agent against both HCT116 and MCF7 cancer cell lines had <italic>IC</italic><sub>50</sub> = 19 and 18 μg/cm<sup>3</sup>, respectively. QSAR analysis indicated the importance of Wiener index (<italic>W</italic>) and energy of the lowest unoccupied molecular orbital (LUMO) in describing the antimicrobial activity of the synthesized compounds.</p></sec><sec><title>Graphical Abstract</title><p><graphic position="anchor" xlink:href="706_2012_877_Figa_HTML" id="MO1"></graphic></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Metwally, Ka" uniqKey="Metwally K">KA Metwally</name></author><author><name sortKey="Abdel Aziz, Lm" uniqKey="Abdel Aziz L">LM Abdel-Aziz</name></author><author><name sortKey="Lashine, Esm" uniqKey="Lashine E">ESM Lashine</name></author><author><name sortKey="Husseiny, Mi" uniqKey="Husseiny M">MI Husseiny</name></author><author><name sortKey="Badawy, Rh" uniqKey="Badawy R">RH Badawy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banerjee, D" uniqKey="Banerjee D">D Banerjee</name></author><author><name sortKey="Yogeeswari, P" uniqKey="Yogeeswari P">P Yogeeswari</name></author><author><name sortKey="Bhat, P" uniqKey="Bhat P">P Bhat</name></author><author><name sortKey="Thomas, A" uniqKey="Thomas A">A Thomas</name></author><author><name sortKey="Srividy, M" uniqKey="Srividy M">M Srividy</name></author><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selvam, P" uniqKey="Selvam P">P Selvam</name></author><author><name sortKey="Chandramohan, M" uniqKey="Chandramohan M">M Chandramohan</name></author><author><name sortKey="Clercq, Ed" uniqKey="Clercq E">ED Clercq</name></author><author><name sortKey="Witvrouw, M" uniqKey="Witvrouw M">M Witvrouw</name></author><author><name sortKey="Pannecouque, C" uniqKey="Pannecouque C">C Pannecouque</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chandrappa, S" uniqKey="Chandrappa S">S Chandrappa</name></author><author><name sortKey="Chandru, H" uniqKey="Chandru H">H Chandru</name></author><author><name sortKey="Sharada, Ac" uniqKey="Sharada A">AC Sharada</name></author><author><name sortKey="Vinaya, K" uniqKey="Vinaya K">K Vinaya</name></author><author><name sortKey="Kumar, Csa" uniqKey="Kumar C">CSA Kumar</name></author><author><name sortKey="Thimmegowda, Nr" uniqKey="Thimmegowda N">NR Thimmegowda</name></author><author><name sortKey="Nagegowda, P" uniqKey="Nagegowda P">P Nagegowda</name></author><author><name sortKey="Kumar, Mk" uniqKey="Kumar M">MK Kumar</name></author><author><name sortKey="Rangappa, Ks" uniqKey="Rangappa K">KS Rangappa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasha, Fa" uniqKey="Pasha F">FA Pasha</name></author><author><name sortKey="Srivastava, Hk" uniqKey="Srivastava H">HK Srivastava</name></author><author><name sortKey="Beg, Y" uniqKey="Beg Y">Y Beg</name></author><author><name sortKey="Singh, Pp" uniqKey="Singh P">PP Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozbek, N" uniqKey="Ozbek N">N Ozbek</name></author><author><name sortKey="Alyar, S" uniqKey="Alyar S">S Alyar</name></author><author><name sortKey="Karacan, N" uniqKey="Karacan N">N Karacan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, Cd" uniqKey="Fan C">CD Fan</name></author><author><name sortKey="Su, H" uniqKey="Su H">H Su</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Zhao, Bx" uniqKey="Zhao B">BX Zhao</name></author><author><name sortKey="Zhang, Sl" uniqKey="Zhang S">SL Zhang</name></author><author><name sortKey="Miao, Jy" uniqKey="Miao J">JY Miao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bairwa, R" uniqKey="Bairwa R">R Bairwa</name></author><author><name sortKey="Kakwani, M" uniqKey="Kakwani M">M Kakwani</name></author><author><name sortKey="Tawari, Nr" uniqKey="Tawari N">NR Tawari</name></author><author><name sortKey="Lalchandani, J" uniqKey="Lalchandani J">J Lalchandani</name></author><author><name sortKey="Ray, Mk" uniqKey="Ray M">MK Ray</name></author><author><name sortKey="Rajan, Mgr" uniqKey="Rajan M">MGR Rajan</name></author><author><name sortKey="Degani, Ms" uniqKey="Degani M">MS Degani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melnyk, P" uniqKey="Melnyk P">P Melnyk</name></author><author><name sortKey="Leroux, V" uniqKey="Leroux V">V Leroux</name></author><author><name sortKey="Sergheraert, C" uniqKey="Sergheraert C">C Sergheraert</name></author><author><name sortKey="Grellier, P" uniqKey="Grellier P">P Grellier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farghaly, Ta" uniqKey="Farghaly T">TA Farghaly</name></author><author><name sortKey="Abdalla, Mm" uniqKey="Abdalla M">MM Abdalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kulandasamy, R" uniqKey="Kulandasamy R">R Kulandasamy</name></author><author><name sortKey="Adhikari, Av" uniqKey="Adhikari A">AV Adhikari</name></author><author><name sortKey="Stables, Jp" uniqKey="Stables J">JP Stables</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bezerra Netto, Hjc" uniqKey="Bezerra Netto H">HJC Bezerra-Netto</name></author><author><name sortKey="Lacerda, Di" uniqKey="Lacerda D">DI Lacerda</name></author><author><name sortKey="Miranda, Alp" uniqKey="Miranda A">ALP Miranda</name></author><author><name sortKey="Alves, Hm" uniqKey="Alves H">HM Alves</name></author><author><name sortKey="Barreiro, Ej" uniqKey="Barreiro E">EJ Barreiro</name></author><author><name sortKey="Fraga, Cam" uniqKey="Fraga C">CAM Fraga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glushkov, Va" uniqKey="Glushkov V">VA Glushkov</name></author><author><name sortKey="Ausheva, Og" uniqKey="Ausheva O">OG Ausheva</name></author><author><name sortKey="Anikina, Lv" uniqKey="Anikina L">LV Anikina</name></author><author><name sortKey="Vikharev, Yb" uniqKey="Vikharev Y">YB Vikharev</name></author><author><name sortKey="Safin, Va" uniqKey="Safin V">VA Safin</name></author><author><name sortKey="Shklyaev, Yv" uniqKey="Shklyaev Y">YV Shklyaev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peat, Aj" uniqKey="Peat A">AJ Peat</name></author><author><name sortKey="Garrido, D" uniqKey="Garrido D">D Garrido</name></author><author><name sortKey="Boucheron, Ja" uniqKey="Boucheron J">JA Boucheron</name></author><author><name sortKey="Schweiker, Sl" uniqKey="Schweiker S">SL Schweiker</name></author><author><name sortKey="Dickerson, Sh" uniqKey="Dickerson S">SH Dickerson</name></author><author><name sortKey="Wilson, Jr" uniqKey="Wilson J">JR Wilson</name></author><author><name sortKey="Wang, Ty" uniqKey="Wang T">TY Wang</name></author><author><name sortKey="Thomson, Sa" uniqKey="Thomson S">SA Thomson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narang, R" uniqKey="Narang R">R Narang</name></author><author><name sortKey="Narasimhan, B" uniqKey="Narasimhan B">B Narasimhan</name></author><author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name></author><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="Yogeeswari, P" uniqKey="Yogeeswari P">P Yogeeswari</name></author><author><name sortKey="Clercq, Ed" uniqKey="Clercq E">ED Clercq</name></author><author><name sortKey="Pannecouque, C" uniqKey="Pannecouque C">C Pannecouque</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Judge, V" uniqKey="Judge V">V Judge</name></author><author><name sortKey="Narasimhan, B" uniqKey="Narasimhan B">B Narasimhan</name></author><author><name sortKey="Ahuja, M" uniqKey="Ahuja M">M Ahuja</name></author><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="Yogeeswari, P" uniqKey="Yogeeswari P">P Yogeeswari</name></author><author><name sortKey="Clercq, Ed" uniqKey="Clercq E">ED Clercq</name></author><author><name sortKey="Pannecouque, C" uniqKey="Pannecouque C">C Pannecouque</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name></author><author><name sortKey="Judge, V" uniqKey="Judge V">V Judge</name></author><author><name sortKey="Narang, R" uniqKey="Narang R">R Narang</name></author><author><name sortKey="Sangwan, S" uniqKey="Sangwan S">S Sangwan</name></author><author><name sortKey="Clercq, Ed" uniqKey="Clercq E">ED Clercq</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author><author><name sortKey="Narasimhan, B" uniqKey="Narasimhan B">B Narasimhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name></author><author><name sortKey="Narasimhan, B" uniqKey="Narasimhan B">B Narasimhan</name></author><author><name sortKey="Sharma, D" uniqKey="Sharma D">D Sharma</name></author><author><name sortKey="Judge, V" uniqKey="Judge V">V Judge</name></author><author><name sortKey="Narang, R" uniqKey="Narang R">R Narang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cappucino, Jg" uniqKey="Cappucino J">JG Cappucino</name></author><author><name sortKey="Sherman, N" uniqKey="Sherman N">N Sherman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emami, S" uniqKey="Emami S">S Emami</name></author><author><name sortKey="Falahati, M" uniqKey="Falahati M">M Falahati</name></author><author><name sortKey="Banifafemi, A" uniqKey="Banifafemi A">A Banifafemi</name></author><author><name sortKey="Shafiee, A" uniqKey="Shafiee A">A Shafiee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pauwels, R" uniqKey="Pauwels R">R Pauwels</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author><author><name sortKey="Baba, M" uniqKey="Baba M">M Baba</name></author><author><name sortKey="Snoeck, R" uniqKey="Snoeck R">R Snoeck</name></author><author><name sortKey="Schols, D" uniqKey="Schols D">D Schols</name></author><author><name sortKey="Herdewijn, P" uniqKey="Herdewijn P">P Herdewijn</name></author><author><name sortKey="Desmyter, J" uniqKey="Desmyter J">J Desmyter</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mosmann, T" uniqKey="Mosmann T">T Mosmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, P" uniqKey="Sharma P">P Sharma</name></author><author><name sortKey="Rane, N" uniqKey="Rane N">N Rane</name></author><author><name sortKey="Gurram, Vk" uniqKey="Gurram V">VK Gurram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamal, A" uniqKey="Kamal A">A Kamal</name></author><author><name sortKey="Reddy, Ks" uniqKey="Reddy K">KS Reddy</name></author><author><name sortKey="Khan, Mna" uniqKey="Khan M">MNA Khan</name></author><author><name sortKey="Shetti, Rvcrnc" uniqKey="Shetti R">RVCRNC Shetti</name></author><author><name sortKey="Ramaiah, Mj" uniqKey="Ramaiah M">MJ Ramaiah</name></author><author><name sortKey="Pushpavalli, Sncvl" uniqKey="Pushpavalli S">SNCVL Pushpavalli</name></author><author><name sortKey="Srinivas, C" uniqKey="Srinivas C">C Srinivas</name></author><author><name sortKey="Bhadra, Mp" uniqKey="Bhadra M">MP Bhadra</name></author><author><name sortKey="Chourasia, M" uniqKey="Chourasia M">M Chourasia</name></author><author><name sortKey="Sastry, Gn" uniqKey="Sastry G">GN Sastry</name></author><author><name sortKey="Juvekar, A" uniqKey="Juvekar A">A Juvekar</name></author><author><name sortKey="Zingde, S" uniqKey="Zingde S">S Zingde</name></author><author><name sortKey="Barkume, M" uniqKey="Barkume M">M Barkume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sortino, M" uniqKey="Sortino M">M Sortino</name></author><author><name sortKey="Delgado, P" uniqKey="Delgado P">P Delgado</name></author><author><name sortKey="Jaurez, S" uniqKey="Jaurez S">S Jaurez</name></author><author><name sortKey="Quiroga, J" uniqKey="Quiroga J">J Quiroga</name></author><author><name sortKey="Abonia, R" uniqKey="Abonia R">R Abonia</name></author><author><name sortKey="Insuasey, B" uniqKey="Insuasey B">B Insuasey</name></author><author><name sortKey="Rodero, Mn" uniqKey="Rodero M">MN Rodero</name></author><author><name sortKey="Garibotto, Fm" uniqKey="Garibotto F">FM Garibotto</name></author><author><name sortKey="Enriz, Rd" uniqKey="Enriz R">RD Enriz</name></author><author><name sortKey="Zaccino, Sa" uniqKey="Zaccino S">SA Zaccino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansch, C" uniqKey="Hansch C">C Hansch</name></author><author><name sortKey="Fujita, T" uniqKey="Fujita T">T Fujita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kier, Lb" uniqKey="Kier L">LB Kier</name></author><author><name sortKey="Hall, Lh" uniqKey="Hall L">LH Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Randic, M" uniqKey="Randic M">M Randic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Randic, M" uniqKey="Randic M">M Randic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balaban, At" uniqKey="Balaban A">AT Balaban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiener, H" uniqKey="Wiener H">H Wiener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prado Rado, Fj" uniqKey="Prado Rado F">FJ Prado–Prado</name></author><author><name sortKey="Gonzalez Diaz, H" uniqKey="Gonzalez Diaz H">H Gonzalez-Diaz</name></author><author><name sortKey="Vega, Omld" uniqKey="Vega O">OMLD Vega</name></author><author><name sortKey="Ubeira, Fm" uniqKey="Ubeira F">FM Ubeira</name></author><author><name sortKey="Chou, Kc" uniqKey="Chou K">KC Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Diaz, H" uniqKey="Gonzalez Diaz H">H Gonzalez-Diaz</name></author><author><name sortKey="Prado Rado, Fj" uniqKey="Prado Rado F">FJ Prado–Prado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruz Monteagudo, M" uniqKey="Cruz Monteagudo M">M Cruz-Monteagudo</name></author><author><name sortKey="Gonzalez Diaz, H" uniqKey="Gonzalez Diaz H">H Gonzalez-Diaz</name></author><author><name sortKey="Aguero Chapin, G" uniqKey="Aguero Chapin G">G Aguero-Chapin</name></author><author><name sortKey="Santana, L" uniqKey="Santana L">L Santana</name></author><author><name sortKey="Borges, F" uniqKey="Borges F">F Borges</name></author><author><name sortKey="Dominguez, Er" uniqKey="Dominguez E">ER Dominguez</name></author><author><name sortKey="Podda, G" uniqKey="Podda G">G Podda</name></author><author><name sortKey="Uriarte, E" uniqKey="Uriarte E">E Uriarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Diaz, H" uniqKey="Gonzalez Diaz H">H Gonzalez-Diaz</name></author><author><name sortKey="Vilar, S" uniqKey="Vilar S">S Vilar</name></author><author><name sortKey="Santana, L" uniqKey="Santana L">L Santana</name></author><author><name sortKey="Uriarte, E" uniqKey="Uriarte E">E Uriarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Golbraikh, A" uniqKey="Golbraikh A">A Golbraikh</name></author><author><name sortKey="Tropsha, A" uniqKey="Tropsha A">A Tropsha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ym" uniqKey="Kim Y">YM Kim</name></author><author><name sortKey="Farrah, S" uniqKey="Farrah S">S Farrah</name></author><author><name sortKey="Baney, Rh" uniqKey="Baney R">RH Baney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Narasimhan, B" uniqKey="Narasimhan B">B Narasimhan</name></author><author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kier, Lb" uniqKey="Kier L">LB Kier</name></author><author><name sortKey="Hall, Lh" uniqKey="Hall L">LH Hall</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bajaj, S" uniqKey="Bajaj S">S Bajaj</name></author><author><name sortKey="Sambi, Ss" uniqKey="Sambi S">SS Sambi</name></author><author><name sortKey="Madan, Ak" uniqKey="Madan A">AK Madan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narasimhan, B" uniqKey="Narasimhan B">B Narasimhan</name></author><author><name sortKey="Judge, V" uniqKey="Judge V">V Judge</name></author><author><name sortKey="Narang, R" uniqKey="Narang R">R Narang</name></author><author><name sortKey="Ohlan, S" uniqKey="Ohlan S">S Ohlan</name></author><author><name sortKey="Ohlan, R" uniqKey="Ohlan R">R Ohlan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Arguelles, Mc" uniqKey="Rodriguez Arguelles M">MC Rodriguez-Arguelles</name></author><author><name sortKey="Lopez Silva, Ec" uniqKey="Lopez Silva E">EC Lopez-Silva</name></author><author><name sortKey="Sanmartin, J" uniqKey="Sanmartin J">J Sanmartin</name></author><author><name sortKey="Pelagatti, P" uniqKey="Pelagatti P">P Pelagatti</name></author><author><name sortKey="Zani, F" uniqKey="Zani F">F Zani</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Monatsh Chem</journal-id><journal-id journal-id-type="iso-abbrev">Monatsh. Chem</journal-id><journal-title-group><journal-title>Monatshefte Fur Chemie</journal-title></journal-title-group><issn pub-type="ppub">0026-9247</issn><issn pub-type="epub">1434-4475</issn><publisher><publisher-name>Springer Vienna</publisher-name><publisher-loc>Vienna</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7087754</article-id><article-id pub-id-type="publisher-id">877</article-id><article-id pub-id-type="doi">10.1007/s00706-012-0877-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title><italic>N</italic>′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Pradeep</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Narasimhan</surname><given-names>Balasubramanian</given-names></name><address><email>naru2000us@yahoo.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ramasamy</surname><given-names>Kalavathy</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mani</surname><given-names>Vasudevan</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mishra</surname><given-names>Rakesh Kumar</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Majeed</surname><given-names>Abu Bakar Abdul</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>De Clercq</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.411524.7</institution-id><institution-id institution-id-type="ISNI">0000000417902262</institution-id><institution>Faculty of Pharmaceutical Sciences,</institution><institution>Maharshi Dayanand University,</institution></institution-wrap>Rohtak, 124001 India</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.412259.9</institution-id><institution-id institution-id-type="ISNI">0000000121611343</institution-id><institution>Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam,</institution><institution>Universiti Teknologi MARA (UiTM),</institution></institution-wrap>Bandar Puncak Alam, 42300 Shan Alam, Selangor Malaysia</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.415751.3</institution-id><institution>Laboratory of Virology and Chemotherapy,</institution><institution>Rega Institute for Medical Research,</institution></institution-wrap>Minderbroedersstraat 10, 3000 Louvain, Belgium</aff></contrib-group><pub-date pub-type="epub"><day>1</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><year>2013</year></pub-date><volume>144</volume><issue>6</issue><fpage>825</fpage><lpage>849</lpage><history><date date-type="received"><day>24</day><month>4</month><year>2012</year></date><date date-type="accepted"><day>12</day><month>10</month><year>2012</year></date></history><permissions><copyright-statement>© Springer-Verlag Wien 2012</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><sec><title>Abstract</title><p>A variety of <italic>N</italic>′-[4-[(substituted imino)methyl]benzylidene]-substituted benzohydrazides have been synthesized and evaluated for antimicrobial and anticancer potential. Results from testing of antimicrobial activity indicated the most potent antimicrobial agents had p<italic>MIC</italic><sub>am</sub> = 1.51. The synthesized compounds were bacteriostatic and fungistatic in action. Results from evaluation of antiviral activity indicated that none of the synthesized hydrazide derivatives inhibited viral replication at sub-toxic concentrations. Results from anti-HIV screening against HIV-2 strain ROD indicated that one compound was more potent (<italic>IC</italic><sub>50</sub> ≥ 1 μg/cm<sup>3</sup>) than the standard drug nevirapine (<italic>IC</italic><sub>50</sub> ≥ 4 μg/cm<sup>3</sup>) and another was equipotent (<italic>IC</italic><sub>50</sub> ≥ 4 μg/cm<sup>3</sup>). The most effective anticancer agent against both HCT116 and MCF7 cancer cell lines had <italic>IC</italic><sub>50</sub> = 19 and 18 μg/cm<sup>3</sup>, respectively. QSAR analysis indicated the importance of Wiener index (<italic>W</italic>) and energy of the lowest unoccupied molecular orbital (LUMO) in describing the antimicrobial activity of the synthesized compounds.</p></sec><sec><title>Graphical Abstract</title><p><graphic position="anchor" xlink:href="706_2012_877_Figa_HTML" id="MO1"></graphic></p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Hydrazides</kwd><kwd>Antimicrobial</kwd><kwd>Antiviral</kwd><kwd>Anticancer</kwd><kwd>QSAR</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag Wien 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Belgique</li><li>Inde</li></country><region><li>Province du Brabant flamand</li></region><settlement><li>Louvain</li></settlement></list><tree><noCountry><name sortKey="Majeed, Abu Bakar Abdul" sort="Majeed, Abu Bakar Abdul" uniqKey="Majeed A" first="Abu Bakar Abdul" last="Majeed">Abu Bakar Abdul Majeed</name><name sortKey="Mani, Vasudevan" sort="Mani, Vasudevan" uniqKey="Mani V" first="Vasudevan" last="Mani">Vasudevan Mani</name><name sortKey="Mishra, Rakesh Kumar" sort="Mishra, Rakesh Kumar" uniqKey="Mishra R" first="Rakesh Kumar" last="Mishra">Rakesh Kumar Mishra</name><name sortKey="Ramasamy, Kalavathy" sort="Ramasamy, Kalavathy" uniqKey="Ramasamy K" first="Kalavathy" last="Ramasamy">Kalavathy Ramasamy</name></noCountry><country name="Inde"><noRegion><name sortKey="Kumar, Pradeep" sort="Kumar, Pradeep" uniqKey="Kumar P" first="Pradeep" last="Kumar">Pradeep Kumar</name></noRegion><name sortKey="Narasimhan, Balasubramanian" sort="Narasimhan, Balasubramanian" uniqKey="Narasimhan B" first="Balasubramanian" last="Narasimhan">Balasubramanian Narasimhan</name></country><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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