Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells
Identifieur interne : 000746 ( Pmc/Checkpoint ); précédent : 000745; suivant : 000747Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells
Auteurs : Jeongyoon Lee [États-Unis] ; Walter G. Bottje [États-Unis] ; Byung-Whi Kong [États-Unis]Source :
- BMC Genomics [ 1471-2164 ] ; 2012.
Abstract
Infectious laryngotracheitis virus (ILTV; gallid herpesvirus 1) infection causes high mortality and huge economic losses in the poultry industry. To protect chickens against ILTV infection, chicken-embryo origin (CEO) and tissue-culture origin (TCO) vaccines have been used. However, the transmission of vaccine ILTV from vaccinated- to unvaccinated chickens can cause severe respiratory disease. Previously, host cell responses against virulent ILTV infections were determined by microarray analysis. In this study, a microarray analysis was performed to understand host-vaccine ILTV interactions at the host gene transcription level.
The 44 K chicken oligo microarrays were used, and the results were compared to those found in virulent ILTV infection. Total RNAs extracted from vaccine ILTV infected chicken embryo lung cells at 1, 2, 3 and 4 days post infection (dpi), compared to 0 dpi, were subjected to microarray assay using the two color hybridization method. Data analysis using JMP Genomics 5.0 and the Ingenuity Pathway Analysis (IPA) program showed that 213 differentially expressed genes could be grouped into a number of functional categories including tissue development, cellular growth and proliferation, cellular movement, and inflammatory responses. Moreover, 10 possible gene networks were created by the IPA program to show intermolecular connections. Interestingly, of 213 differentially expressed genes, BMP2, C8orf79, F10, and NPY were expressed distinctly in vaccine ILTV infection when compared to virulent ILTV infection.
Comprehensive knowledge of gene expression and biological functionalities of host factors during vaccine ILTV infection can provide insight into host cellular defense mechanisms compared to those of virulent ILTV.
The online version of this article (doi:10.1186/1471-2164-13-143) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1471-2164-13-143
PubMed: 22530940
PubMed Central: 3353197
Affiliations:
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Infectious laryngotracheitis virus (ILTV; gallid herpesvirus 1) infection causes high mortality and huge economic losses in the poultry industry. To protect chickens against ILTV infection, chicken-embryo origin (CEO) and tissue-culture origin (TCO) vaccines have been used. However, the transmission of vaccine ILTV from vaccinated- to unvaccinated chickens can cause severe respiratory disease. Previously, host cell responses against virulent ILTV infections were determined by microarray analysis. In this study, a microarray analysis was performed to understand host-vaccine ILTV interactions at the host gene transcription level.</p>
</sec>
<sec><title>Results</title>
<p>The 44 K chicken oligo microarrays were used, and the results were compared to those found in virulent ILTV infection. Total RNAs extracted from vaccine ILTV infected chicken embryo lung cells at 1, 2, 3 and 4 days post infection (dpi), compared to 0 dpi, were subjected to microarray assay using the two color hybridization method. Data analysis using JMP Genomics 5.0 and the Ingenuity Pathway Analysis (IPA) program showed that 213 differentially expressed genes could be grouped into a number of functional categories including tissue development, cellular growth and proliferation, cellular movement, and inflammatory responses. Moreover, 10 possible gene networks were created by the IPA program to show intermolecular connections. Interestingly, of 213 differentially expressed genes, BMP2, C8orf79, F10, and NPY were expressed distinctly in vaccine ILTV infection when compared to virulent ILTV infection.</p>
</sec>
<sec><title>Conclusions</title>
<p>Comprehensive knowledge of gene expression and biological functionalities of host factors during vaccine ILTV infection can provide insight into host cellular defense mechanisms compared to those of virulent ILTV.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2164-13-143) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Genomics</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Genomics</journal-id>
<journal-title-group><journal-title>BMC Genomics</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2164</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22530940</article-id>
<article-id pub-id-type="pmc">3353197</article-id>
<article-id pub-id-type="publisher-id">3978</article-id>
<article-id pub-id-type="doi">10.1186/1471-2164-13-143</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Jeongyoon</given-names>
</name>
<address><email>hgomdol@uark.edu</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bottje</surname>
<given-names>Walter G</given-names>
</name>
<address><email>wbottje@uark.edu</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kong</surname>
<given-names>Byung-Whi</given-names>
</name>
<address><email>bkong@uark.edu</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Poultry Science, Division of Agriculture, POSC O-404, 1260 West Maple, Fayetteville, AR 72701 USA</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.411017.2</institution-id>
<institution-id institution-id-type="ISNI">0000000121510999</institution-id>
<institution>Cell and Molecular Biology Graduate Program,</institution>
<institution>University of Arkansas,</institution>
</institution-wrap>
Fayetteville, AR 72701 USA</aff>
</contrib-group>
<pub-date pub-type="epub"><day>24</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>24</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<volume>13</volume>
<elocation-id>143</elocation-id>
<history><date date-type="received"><day>13</day>
<month>8</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>24</day>
<month>4</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© Lee et al; licensee BioMed Central Ltd. 2012</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Infectious laryngotracheitis virus (ILTV; gallid herpesvirus 1) infection causes high mortality and huge economic losses in the poultry industry. To protect chickens against ILTV infection, chicken-embryo origin (CEO) and tissue-culture origin (TCO) vaccines have been used. However, the transmission of vaccine ILTV from vaccinated- to unvaccinated chickens can cause severe respiratory disease. Previously, host cell responses against virulent ILTV infections were determined by microarray analysis. In this study, a microarray analysis was performed to understand host-vaccine ILTV interactions at the host gene transcription level.</p>
</sec>
<sec><title>Results</title>
<p>The 44 K chicken oligo microarrays were used, and the results were compared to those found in virulent ILTV infection. Total RNAs extracted from vaccine ILTV infected chicken embryo lung cells at 1, 2, 3 and 4 days post infection (dpi), compared to 0 dpi, were subjected to microarray assay using the two color hybridization method. Data analysis using JMP Genomics 5.0 and the Ingenuity Pathway Analysis (IPA) program showed that 213 differentially expressed genes could be grouped into a number of functional categories including tissue development, cellular growth and proliferation, cellular movement, and inflammatory responses. Moreover, 10 possible gene networks were created by the IPA program to show intermolecular connections. Interestingly, of 213 differentially expressed genes, BMP2, C8orf79, F10, and NPY were expressed distinctly in vaccine ILTV infection when compared to virulent ILTV infection.</p>
</sec>
<sec><title>Conclusions</title>
<p>Comprehensive knowledge of gene expression and biological functionalities of host factors during vaccine ILTV infection can provide insight into host cellular defense mechanisms compared to those of virulent ILTV.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2164-13-143) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Ingenuity Pathway Analysis</kwd>
<kwd>Japanese Encephalitis Virus</kwd>
<kwd>Chicken Anemia Virus</kwd>
<kwd>Laryngotracheitis</kwd>
<kwd>Gallid Herpesvirus</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2012</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arkansas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Arkansas"><name sortKey="Lee, Jeongyoon" sort="Lee, Jeongyoon" uniqKey="Lee J" first="Jeongyoon" last="Lee">Jeongyoon Lee</name>
</region>
<name sortKey="Bottje, Walter G" sort="Bottje, Walter G" uniqKey="Bottje W" first="Walter G" last="Bottje">Walter G. Bottje</name>
<name sortKey="Bottje, Walter G" sort="Bottje, Walter G" uniqKey="Bottje W" first="Walter G" last="Bottje">Walter G. Bottje</name>
<name sortKey="Kong, Byung Whi" sort="Kong, Byung Whi" uniqKey="Kong B" first="Byung-Whi" last="Kong">Byung-Whi Kong</name>
<name sortKey="Kong, Byung Whi" sort="Kong, Byung Whi" uniqKey="Kong B" first="Byung-Whi" last="Kong">Byung-Whi Kong</name>
<name sortKey="Lee, Jeongyoon" sort="Lee, Jeongyoon" uniqKey="Lee J" first="Jeongyoon" last="Lee">Jeongyoon Lee</name>
</country>
</tree>
</affiliations>
</record>
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