Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
Identifieur interne : 000004 ( Pmc/Checkpoint ); précédent : 000003; suivant : 000005Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
Auteurs : Jin Yong Kim [Corée du Sud] ; Jae-Hoon Ko [Corée du Sud] ; Yeonjae Kim [Corée du Sud] ; Yae-Jean Kim [Corée du Sud] ; Jeong-Min Kim [Corée du Sud] ; Yoon-Seok Chung [Corée du Sud] ; Heui Man Kim [Corée du Sud] ; Myung-Guk Han [Corée du Sud] ; So Yeon Kim [Corée du Sud] ; Bum Sik Chin [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2020.
Abstract
As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.
Url:
DOI: 10.3346/jkms.2020.35.e86
PubMed: 32080991
PubMed Central: 7036338
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7036338Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea</title><author><name sortKey="Kim, Jin Yong" sort="Kim, Jin Yong" uniqKey="Kim J" first="Jin Yong" last="Kim">Jin Yong Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Jae Hoon" sort="Ko, Jae Hoon" uniqKey="Ko J" first="Jae-Hoon" last="Ko">Jae-Hoon Ko</name><affiliation wicri:level="1"><nlm:aff id="A2">Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jeong Min" sort="Kim, Jeong Min" uniqKey="Kim J" first="Jeong-Min" last="Kim">Jeong-Min Kim</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Yoon Seok" sort="Chung, Yoon Seok" uniqKey="Chung Y" first="Yoon-Seok" last="Chung">Yoon-Seok Chung</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Heui Man" sort="Kim, Heui Man" uniqKey="Kim H" first="Heui Man" last="Kim">Heui Man Kim</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Myung Guk" sort="Han, Myung Guk" uniqKey="Han M" first="Myung-Guk" last="Han">Myung-Guk Han</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, So Yeon" sort="Kim, So Yeon" uniqKey="Kim S" first="So Yeon" last="Kim">So Yeon Kim</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Laboratory Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32080991</idno><idno type="pmc">7036338</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036338</idno><idno type="RBID">PMC:7036338</idno><idno type="doi">10.3346/jkms.2020.35.e86</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000535</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000535</idno><idno type="wicri:Area/Pmc/Curation">000535</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000535</idno><idno type="wicri:Area/Pmc/Checkpoint">000004</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000004</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea</title><author><name sortKey="Kim, Jin Yong" sort="Kim, Jin Yong" uniqKey="Kim J" first="Jin Yong" last="Kim">Jin Yong Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Jae Hoon" sort="Ko, Jae Hoon" uniqKey="Ko J" first="Jae-Hoon" last="Ko">Jae-Hoon Ko</name><affiliation wicri:level="1"><nlm:aff id="A2">Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jeong Min" sort="Kim, Jeong Min" uniqKey="Kim J" first="Jeong-Min" last="Kim">Jeong-Min Kim</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Yoon Seok" sort="Chung, Yoon Seok" uniqKey="Chung Y" first="Yoon-Seok" last="Chung">Yoon-Seok Chung</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Heui Man" sort="Kim, Heui Man" uniqKey="Kim H" first="Heui Man" last="Kim">Heui Man Kim</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Myung Guk" sort="Han, Myung Guk" uniqKey="Han M" first="Myung-Guk" last="Han">Myung-Guk Han</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, So Yeon" sort="Kim, So Yeon" uniqKey="Kim S" first="So Yeon" last="Kim">So Yeon Kim</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Laboratory Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gulyaeva, Aa" uniqKey="Gulyaeva A">AA Gulyaeva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X Guan</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Landt, O" uniqKey="Landt O">O Landt</name></author><author><name sortKey="Kaiser, M" uniqKey="Kaiser M">M Kaiser</name></author><author><name sortKey="Molenkamp, R" uniqKey="Molenkamp R">R Molenkamp</name></author><author><name sortKey="Meijer, A" uniqKey="Meijer A">A Meijer</name></author><author><name sortKey="Chu, Dk" uniqKey="Chu D">DK Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name></author><author><name sortKey="Oh, Y" uniqKey="Oh Y">Y Oh</name></author><author><name sortKey="Oh, Kj" uniqKey="Oh K">KJ Oh</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chan, Ks" uniqKey="Chan K">KS Chan</name></author><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huh, Hj" uniqKey="Huh H">HJ Huh</name></author><author><name sortKey="Ko, Jh" uniqKey="Ko J">JH Ko</name></author><author><name sortKey="Kim, Ye" uniqKey="Kim Y">YE Kim</name></author><author><name sortKey="Park, Ch" uniqKey="Park C">CH Park</name></author><author><name sortKey="Hong, G" uniqKey="Hong G">G Hong</name></author><author><name sortKey="Choi, R" uniqKey="Choi R">R Choi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Korean Med. Sci</journal-id><journal-id journal-id-type="publisher-id">JKMS</journal-id><journal-title-group><journal-title>Journal of Korean Medical Science</journal-title></journal-title-group><issn pub-type="ppub">1011-8934</issn><issn pub-type="epub">1598-6357</issn><publisher><publisher-name>The Korean Academy of Medical Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32080991</article-id><article-id pub-id-type="pmc">7036338</article-id><article-id pub-id-type="doi">10.3346/jkms.2020.35.e86</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject><subj-group subj-group-type="subheading"><subject>Infectious Diseases, Microbiology & Parasitology</subject></subj-group></subj-group></article-categories><title-group><article-title>Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-4306-1597</contrib-id><name><surname>Kim</surname><given-names>Jin Yong</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-9490-6609</contrib-id><name><surname>Ko</surname><given-names>Jae-Hoon</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4144-9077</contrib-id><name><surname>Kim</surname><given-names>Yeonjae</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-8367-3424</contrib-id><name><surname>Kim</surname><given-names>Yae-Jean</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-8240-0395</contrib-id><name><surname>Kim</surname><given-names>Jeong-Min</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4562-5533</contrib-id><name><surname>Chung</surname><given-names>Yoon-Seok</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-2908-6437</contrib-id><name><surname>Kim</surname><given-names>Heui Man</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3543-1826</contrib-id><name><surname>Han</surname><given-names>Myung-Guk</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1774-0382</contrib-id><name><surname>Kim</surname><given-names>So Yeon</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-3021-1434</contrib-id><name><surname>Chin</surname><given-names>Bum Sik</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon,<country>Korea</country>.</aff><aff id="A2"><label>2</label>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>.</aff><aff id="A3"><label>3</label>Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</aff><aff id="A4"><label>4</label>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>.</aff><aff id="A5"><label>5</label>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju,<country>Korea</country>.</aff><aff id="A6"><label>6</label>Department of Laboratory Medicine, National Medical Center, Seoul,<country>Korea</country>.</aff><author-notes><corresp>Address for Correspondence: Bum Sik Chin, MD, PhD. Department of Internal Medicine, National Medical Center, 245 Eulji-ro, Jung-gu, Seoul 04564, Korea. <email>moberrer@nmc.or.kr</email></corresp><fn id="FN1" fn-type="equal"><p><sup>*</sup>Jin Yong Kim and Jae-Hoon Ko contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>20</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="collection"><day>24</day><month>2</month><year>2020</year></pub-date><volume>35</volume><issue>7</issue><elocation-id>e86</elocation-id><history><date date-type="received"><day>14</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>19</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 The Korean Academy of Medical Sciences.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>The Korean Academy of Medical Sciences</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.</p></abstract><kwd-group kwd-group-type="author"><kwd>Coronavirus</kwd><kwd>SARS-CoV-2</kwd><kwd>2019-nCoV</kwd><kwd>COVID-19</kwd><kwd>Viral Load Kinetics</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" fig-type="figure" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Viral load kinetics according to the clinical course of the first two SARS-CoV-2 infected patients in Korea. (<bold>A</bold>) Viral load kinetics and clinical course of Patient 1. (<bold>B</bold>) Viral load kinetics and clinical course of Patient 2.</title><p>URT = upper respiratory tract, LRT = lower respiratory tract, ND = not detected, CXR = chest X-ray, GGO = ground glass opacity, CT = computed tomography, SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2.</p><p><sup>a)</sup>In Patient 2, the exact fever duration could not be estimated because he had taken non-steroidal anti-inflammatory agent to control his myalgia and sore throat before hospitalization. When his physician discontinued the medication, the fever was observed; <sup>b)</sup>Patient 2 experienced loose stool after taking Lopinavir/ritonavir.</p></caption><graphic xlink:href="jkms-35-e86-g001"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Jin Yong" sort="Kim, Jin Yong" uniqKey="Kim J" first="Jin Yong" last="Kim">Jin Yong Kim</name></noRegion><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><name sortKey="Chung, Yoon Seok" sort="Chung, Yoon Seok" uniqKey="Chung Y" first="Yoon-Seok" last="Chung">Yoon-Seok Chung</name><name sortKey="Han, Myung Guk" sort="Han, Myung Guk" uniqKey="Han M" first="Myung-Guk" last="Han">Myung-Guk Han</name><name sortKey="Kim, Heui Man" sort="Kim, Heui Man" uniqKey="Kim H" first="Heui Man" last="Kim">Heui Man Kim</name><name sortKey="Kim, Jeong Min" sort="Kim, Jeong Min" uniqKey="Kim J" first="Jeong-Min" last="Kim">Jeong-Min Kim</name><name sortKey="Kim, So Yeon" sort="Kim, So Yeon" uniqKey="Kim S" first="So Yeon" last="Kim">So Yeon Kim</name><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><name sortKey="Ko, Jae Hoon" sort="Ko, Jae Hoon" uniqKey="Ko J" first="Jae-Hoon" last="Ko">Jae-Hoon Ko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000004 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000004 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:7036338
|texte= Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:32080991" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |