Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton
Identifieur interne : 000012 ( PascalFrancis/Curation ); précédent : 000011; suivant : 000013Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton
Auteurs : YU ZHONG [Japon] ; Yoshiyuki Yoshinaka [Japon] ; Tadahiro Takeda [Japon] ; Noriko Shimizu [Japon] ; Sayaka Yoshizaki [Japon] ; Yoshio Inagaki [Japon] ; Shinobu Matsuda [Japon] ; Gisho Honda [Japon] ; Nobutaka Fujii [Japon] ; Naoki Yamamoto [Japon]Source :
- Antiviral research [ 0166-3542 ] ; 2005.
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Abstract
A water-soluble extract of fermented Polygonum tinctorium Aiton (Polygonaceae) called Sukumo, exhibited a potent inhibitory activity against HIV type 1 in vitro. The extract potently suppressed acute HIV-1 (Ills) infection in MT-4 cells with EC50 values of 0.5 μg/ml but exhibited low cytotoxicity to MT-4 cells even at a high concentration (CC50 > 1000 μg/ml). It also inhibited giant cell formation in co-cultures of HIV-infected cells and uninfected Molt-4 cells. Sukumo extract was found to interact with both the viral envelope glycoprotein and cellular receptors, thus blocking virus-cell binding and virus-induced syncytium formation. There was a good correlation between the extract's anti-HIV-1 activity and its inhibitory effects on HIV-1 binding. It also suppressed replication of herpes simplex virus type 1 in Vero cells with an EC50 of 11.56 μg/ml. On the other hand, there was no appreciable activity against influenza A virus, poliovirus or SARS corona virus when tested at concentrations ranging from 3.2-400 μg/ml as shown by microscopic image analysis for cytopathic effect (CPE). Physico-chemical studies revealed that the anti-HIV activity in the extract was essentially maintained after boiling at 100 °C in 1N HCl or IN NaOH, and after treatment with 100mM NaIO4. The inhibitory activity of the extract was also not reduced after pronase digestion. The active factor in the extract is likely to be a novel compound(s) having a polyanionic substructure and a molecular weight of 10,000-50,000.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton</title><author><name sortKey="Yu Zhong" sort="Yu Zhong" uniqKey="Yu Zhong" last="Yu Zhong">YU ZHONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima</s1><s2>Bunkyo-ku, Tokyo 113-8519</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Yoshinaka, Yoshiyuki" sort="Yoshinaka, Yoshiyuki" uniqKey="Yoshinaka Y" first="Yoshiyuki" last="Yoshinaka">Yoshiyuki Yoshinaka</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Human Gene Sciences Center, Tokyo Medical and Dental University</s1><s2>Bunkyo-ku, Tokyo 113-8519</s2><s3>JPN</s3><sZ>2 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Takeda, Tadahiro" sort="Takeda, Tadahiro" uniqKey="Takeda T" first="Tadahiro" last="Takeda">Tadahiro Takeda</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Kyoritsu University of Pharmacy</s1><s2>Minato-ku, 105-8512, Tokyo</s2><s3>JPN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Shimizu, Noriko" sort="Shimizu, Noriko" uniqKey="Shimizu N" first="Noriko" last="Shimizu">Noriko Shimizu</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Kyoritsu University of Pharmacy</s1><s2>Minato-ku, 105-8512, Tokyo</s2><s3>JPN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Yoshizaki, Sayaka" sort="Yoshizaki, Sayaka" uniqKey="Yoshizaki S" first="Sayaka" last="Yoshizaki">Sayaka Yoshizaki</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Institute of Infectious Diseases</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Inagaki, Yoshio" sort="Inagaki, Yoshio" uniqKey="Inagaki Y" first="Yoshio" last="Inagaki">Yoshio Inagaki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima</s1><s2>Bunkyo-ku, Tokyo 113-8519</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Matsuda, Shinobu" sort="Matsuda, Shinobu" uniqKey="Matsuda S" first="Shinobu" last="Matsuda">Shinobu Matsuda</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Hemorheological Function of Food Co. 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Ltd</s1><s2>Hyogo</s2><s3>JPN</s3><sZ>7 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Honda, Gisho" sort="Honda, Gisho" uniqKey="Honda G" first="Gisho" last="Honda">Gisho Honda</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Graduate School of Pharmaceutical Sciences, Kyoto University</s1><s2>Sakyo-ku, Kyoto 606-8501</s2><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Fujii, Nobutaka" sort="Fujii, Nobutaka" uniqKey="Fujii N" first="Nobutaka" last="Fujii">Nobutaka Fujii</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Graduate School of Pharmaceutical Sciences, Kyoto University</s1><s2>Sakyo-ku, Kyoto 606-8501</s2><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima</s1><s2>Bunkyo-ku, Tokyo 113-8519</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Institute of Infectious Diseases</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author></analytic><series><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Antiretroviral agent</term><term>Antiviral</term><term>Extract</term><term>HIV-1 virus</term><term>Human herpesvirus 1</term><term>Polygonum</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Antiviral</term><term>Antirétroviral</term><term>Virus HIV1</term><term>SIDA</term><term>Polygonum</term><term>Extrait</term><term>Herpesvirus hominis 1</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A water-soluble extract of fermented Polygonum tinctorium Aiton (Polygonaceae) called Sukumo, exhibited a potent inhibitory activity against HIV type 1 in vitro. The extract potently suppressed acute HIV-1 (Ills) infection in MT-4 cells with EC<sub>50</sub> values of 0.5 μg/ml but exhibited low cytotoxicity to MT-4 cells even at a high concentration (CC<sub>50</sub> > 1000 μg/ml). It also inhibited giant cell formation in co-cultures of HIV-infected cells and uninfected Molt-4 cells. Sukumo extract was found to interact with both the viral envelope glycoprotein and cellular receptors, thus blocking virus-cell binding and virus-induced syncytium formation. There was a good correlation between the extract's anti-HIV-1 activity and its inhibitory effects on HIV-1 binding. It also suppressed replication of herpes simplex virus type 1 in Vero cells with an EC<sub>50</sub> of 11.56 μg/ml. On the other hand, there was no appreciable activity against influenza A virus, poliovirus or SARS corona virus when tested at concentrations ranging from 3.2-400 μg/ml as shown by microscopic image analysis for cytopathic effect (CPE). Physico-chemical studies revealed that the anti-HIV activity in the extract was essentially maintained after boiling at 100 °C in 1N HCl or IN NaOH, and after treatment with 100mM NaIO<sub>4</sub>. The inhibitory activity of the extract was also not reduced after pronase digestion. The active factor in the extract is likely to be a novel compound(s) having a polyanionic substructure and a molecular weight of 10,000-50,000.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0166-3542</s0></fA01><fA02 i1="01"><s0>ARSRDR</s0></fA02><fA03 i2="1"><s0>Antivir. res.</s0></fA03><fA05><s2>66</s2></fA05><fA06><s2>2-3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton</s1></fA08><fA11 i1="01" i2="1"><s1>YU ZHONG</s1></fA11><fA11 i1="02" i2="1"><s1>YOSHINAKA (Yoshiyuki)</s1></fA11><fA11 i1="03" i2="1"><s1>TAKEDA (Tadahiro)</s1></fA11><fA11 i1="04" i2="1"><s1>SHIMIZU (Noriko)</s1></fA11><fA11 i1="05" i2="1"><s1>YOSHIZAKI (Sayaka)</s1></fA11><fA11 i1="06" i2="1"><s1>INAGAKI (Yoshio)</s1></fA11><fA11 i1="07" i2="1"><s1>MATSUDA (Shinobu)</s1></fA11><fA11 i1="08" i2="1"><s1>HONDA (Gisho)</s1></fA11><fA11 i1="09" i2="1"><s1>FUJII (Nobutaka)</s1></fA11><fA11 i1="10" i2="1"><s1>YAMAMOTO (Naoki)</s1></fA11><fA14 i1="01"><s1>Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima</s1><s2>Bunkyo-ku, Tokyo 113-8519</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Human Gene Sciences Center, Tokyo Medical and Dental University</s1><s2>Bunkyo-ku, Tokyo 113-8519</s2><s3>JPN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Kyoritsu University of Pharmacy</s1><s2>Minato-ku, 105-8512, Tokyo</s2><s3>JPN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>National Institute of Infectious Diseases</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="05"><s1>Institute of Hemorheological Function of Food Co. Ltd</s1><s2>Hyogo</s2><s3>JPN</s3><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Graduate School of Pharmaceutical Sciences, Kyoto University</s1><s2>Sakyo-ku, Kyoto 606-8501</s2><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></fA14><fA20><s1>119-128</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18839</s2><s5>354000124703740050</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>22 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0266877</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Antiviral research</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>A water-soluble extract of fermented Polygonum tinctorium Aiton (Polygonaceae) called Sukumo, exhibited a potent inhibitory activity against HIV type 1 in vitro. The extract potently suppressed acute HIV-1 (Ills) infection in MT-4 cells with EC<sub>50</sub> values of 0.5 μg/ml but exhibited low cytotoxicity to MT-4 cells even at a high concentration (CC<sub>50</sub> > 1000 μg/ml). It also inhibited giant cell formation in co-cultures of HIV-infected cells and uninfected Molt-4 cells. Sukumo extract was found to interact with both the viral envelope glycoprotein and cellular receptors, thus blocking virus-cell binding and virus-induced syncytium formation. There was a good correlation between the extract's anti-HIV-1 activity and its inhibitory effects on HIV-1 binding. It also suppressed replication of herpes simplex virus type 1 in Vero cells with an EC<sub>50</sub> of 11.56 μg/ml. On the other hand, there was no appreciable activity against influenza A virus, poliovirus or SARS corona virus when tested at concentrations ranging from 3.2-400 μg/ml as shown by microscopic image analysis for cytopathic effect (CPE). Physico-chemical studies revealed that the anti-HIV activity in the extract was essentially maintained after boiling at 100 °C in 1N HCl or IN NaOH, and after treatment with 100mM NaIO<sub>4</sub>. The inhibitory activity of the extract was also not reduced after pronase digestion. The active factor in the extract is likely to be a novel compound(s) having a polyanionic substructure and a molecular weight of 10,000-50,000.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02S05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Antiviral</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Antiviral</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Antiviral</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Antirétroviral</s0><s2>FR</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Antiretroviral agent</s0><s2>FR</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Antiretroviral</s0><s2>FR</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Virus HIV1</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>HIV-1 virus</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>HIV-1 virus</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>SIDA</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>AIDS</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>SIDA</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Polygonum</s0><s2>NS</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Polygonum</s0><s2>NS</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Polygonum</s0><s2>NS</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Extrait</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Extract</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Extracto</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Herpesvirus hominis 1</s0><s2>NW</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Human herpesvirus 1</s0><s2>NW</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Herpesvirus hominis 1</s0><s2>NW</s2><s5>07</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virus immunodéficience humaine</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Human immunodeficiency virus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Lentivirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Lentivirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Lentivirus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Retroviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Retroviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Retroviridae</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Polygonaceae</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Polygonaceae</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Polygonaceae</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Dicotyledones</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Dicotyledones</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Dicotyledones</s0><s2>NS</s2></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Angiospermae</s0><s2>NS</s2></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Angiospermae</s0><s2>NS</s2></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Angiospermae</s0><s2>NS</s2></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Spermatophyta</s0><s2>NS</s2></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Spermatophyta</s0><s2>NS</s2></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Spermatophyta</s0><s2>NS</s2></fC07><fC07 i1="11" i2="X" l="FRE"><s0>Alphaherpesvirinae</s0><s2>NW</s2></fC07><fC07 i1="11" i2="X" l="ENG"><s0>Alphaherpesvirinae</s0><s2>NW</s2></fC07><fC07 i1="11" i2="X" l="SPA"><s0>Alphaherpesvirinae</s0><s2>NW</s2></fC07><fC07 i1="12" i2="X" l="FRE"><s0>Herpesviridae</s0><s2>NW</s2></fC07><fC07 i1="12" i2="X" l="ENG"><s0>Herpesviridae</s0><s2>NW</s2></fC07><fC07 i1="12" i2="X" l="SPA"><s0>Herpesviridae</s0><s2>NW</s2></fC07><fC07 i1="13" i2="X" l="FRE"><s0>Immunodéficit</s0><s5>37</s5></fC07><fC07 i1="13" i2="X" l="ENG"><s0>Immune deficiency</s0><s5>37</s5></fC07><fC07 i1="13" i2="X" l="SPA"><s0>Inmunodeficiencia</s0><s5>37</s5></fC07><fC07 i1="14" i2="X" l="FRE"><s0>Immunopathologie</s0><s5>39</s5></fC07><fC07 i1="14" i2="X" l="ENG"><s0>Immunopathology</s0><s5>39</s5></fC07><fC07 i1="14" i2="X" l="SPA"><s0>Inmunopatología</s0><s5>39</s5></fC07><fN21><s1>185</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Wicri/Sante
|area= CovidV2
|flux= PascalFrancis
|étape= Curation
|type= RBID
|clé= Pascal:05-0266877
|texte= Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton
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