CovidV2, PascalFrancis, Corpus, bibRecord, 000060

Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies

Identifieur interne : 000060 ( PascalFrancis/Corpus ); précédent : 000059; suivant : 000061

Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies

Auteurs : H. Kasai ; E. Morita ; K. Hatakeyama ; K. Sugiyama

Source :

Archives of virology [ 0304-8608 ] ; 1998.

RBID : Pascal:99-0084586

Descripteurs français

Pascal (Inist)
- Virus hépatite murine, Protéine, Hémagglutinine, Esterases, Caractérisation, Anticorps monoclonal, Antigène, Déterminant antigénique, Surface virus.

English descriptors

KwdEn :
- Antigen, Antigenic determinant, Characterization, Esterases, Hemagglutinin, Monoclonal antibody, Murine hepatitis virus, Protein, Virus surface.

Abstract

We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28. 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Arch. virol.`
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A08	`01`	`1`	`ENG`	`@1 Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies`
A11	`01`	`1`		`@1 KASAI (H.)`
A11	`02`	`1`		`@1 MORITA (E.)`
A11	`03`	`1`		`@1 HATAKEYAMA (K.)`
A11	`04`	`1`		`@1 SUGIYAMA (K.)`
A14	`01`			`@1 Department of Biology, Faculty of Science, Hirosaki University @2 Hirosaki @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A20				`@1 1941-1948`
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A64		`1`		`@0 Archives of virology`
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C01	`01`		`ENG`	@0 We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28. 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.
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C03	`07`	`X`	`FRE`	`@0 Antigène @5 08`
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C03	`09`	`X`	`SPA`	`@0 Superficie virus @5 10`
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C07	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
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C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
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C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`05`	`X`	`FRE`	`@0 Hydrolases @2 FE`
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C07	`06`	`X`	`FRE`	`@0 Enzyme`
C07	`06`	`X`	`ENG`	`@0 Enzyme`
C07	`06`	`X`	`SPA`	`@0 Enzima`
N21				`@1 046`

Format Inist (serveur)

NO :	PASCAL 99-0084586 INIST
ET :	Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies
AU :	KASAI (H.); MORITA (E.); HATAKEYAMA (K.); SUGIYAMA (K.)
AF :	Department of Biology, Faculty of Science, Hirosaki University/Hirosaki/Japon (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Archives of virology; ISSN 0304-8608; Autriche; Da. 1998; Vol. 143; No. 10; Pp. 1941-1948; Bibl. 10 ref.
LA :	Anglais
EA :	We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28. 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.
CC :	002A05C03
FD :	Virus hépatite murine; Protéine; Hémagglutinine; Esterases; Caractérisation; Anticorps monoclonal; Antigène; Déterminant antigénique; Surface virus
FG :	Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme
ED :	Murine hepatitis virus; Protein; Hemagglutinin; Esterases; Characterization; Monoclonal antibody; Antigen; Antigenic determinant; Virus surface
EG :	Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme
SD :	Murine hepatitis virus; Proteína; Hemoaglutinina; Esterases; Caracterización; Anticuerpo monoclonal; Antígeno; Determinante antigénico; Superficie virus
LO :	INIST-6355.354000072881610070
ID :	99-0084586

Links to Exploration step

Pascal:99-0084586

Le document en format XML

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<front><div type="abstract" xml:lang="en">We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28. 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.</div>
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<fC01 i1="01" l="ENG"><s0>We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28. 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.</s0>
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<server><NO>PASCAL 99-0084586 INIST</NO>
<ET>Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies</ET>
<AU>KASAI (H.); MORITA (E.); HATAKEYAMA (K.); SUGIYAMA (K.)</AU>
<AF>Department of Biology, Faculty of Science, Hirosaki University/Hirosaki/Japon (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Archives of virology; ISSN 0304-8608; Autriche; Da. 1998; Vol. 143; No. 10; Pp. 1941-1948; Bibl. 10 ref.</SO>
<LA>Anglais</LA>
<EA>We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28. 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.</EA>
<CC>002A05C03</CC>
<FD>Virus hépatite murine; Protéine; Hémagglutinine; Esterases; Caractérisation; Anticorps monoclonal; Antigène; Déterminant antigénique; Surface virus</FD>
<FG>Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme</FG>
<ED>Murine hepatitis virus; Protein; Hemagglutinin; Esterases; Characterization; Monoclonal antibody; Antigen; Antigenic determinant; Virus surface</ED>
<EG>Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme</EG>
<SD>Murine hepatitis virus; Proteína; Hemoaglutinina; Esterases; Caracterización; Anticuerpo monoclonal; Antígeno; Determinante antigénico; Superficie virus</SD>
<LO>INIST-6355.354000072881610070</LO>
<ID>99-0084586</ID>
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Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies

Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies

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