CovidV2, PascalFrancis, Corpus, bibRecord, 000027

Vaccine-induced enhancement of viral infections

Identifieur interne : 000027 ( PascalFrancis/Corpus ); précédent : 000026; suivant : 000028

Vaccine-induced enhancement of viral infections

Auteurs : W. Huisman ; B. E. E. Martina ; G. F. Rimmelzwaan ; R. A. Gruters ; A. D. M. E. Osterhaus

Source :

Vaccine [ 0264-410X ] ; 2009.

RBID : Pascal:09-0108127

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Vaccin, Virose.

English descriptors

KwdEn :
- Human immunodeficiency virus, Vaccine, Viral disease.

Abstract

Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 HUISMAN (W.)`
A11	`02`	`1`		`@1 MARTINA (B. E. E.)`
A11	`03`	`1`		`@1 RIMMELZWAAN (G. F.)`
A11	`04`	`1`		`@1 GRUTERS (R. A.)`
A11	`05`	`1`		`@1 OSTERHAUS (A. D. M. E.)`
A14	`01`			`@1 Erasmus MC, Institute of Virology, P.O. Box 1738 @2 3000 DR Rotterdam @3 NLD @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
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N21				`@1 075`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 09-0108127 INIST
ET :	Vaccine-induced enhancement of viral infections
AU :	HUISMAN (W.); MARTINA (B. E. E.); RIMMELZWAAN (G. F.); GRUTERS (R. A.); OSTERHAUS (A. D. M. E.)
AF :	Erasmus MC, Institute of Virology, P.O. Box 1738/3000 DR Rotterdam/Pays-Bas (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2009; Vol. 27; No. 4; Pp. 505-512; Bibl. 128 ref.
LA :	Anglais
EA :	Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.
CC :	002A05F04; 002A05C10
FD :	Virus immunodéficience humaine; Vaccin; Virose
FG :	Lentivirus; Retroviridae; Virus; Infection
ED :	Human immunodeficiency virus; Vaccine; Viral disease
EG :	Lentivirus; Retroviridae; Virus; Infection
SD :	Human immunodeficiency virus; Vacuna; Virosis
LO :	INIST-20289.354000184207870020
ID :	09-0108127

Links to Exploration step

Pascal:09-0108127

Le document en format XML

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<front><div type="abstract" xml:lang="en">Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.</div>
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<server><NO>PASCAL 09-0108127 INIST</NO>
<ET>Vaccine-induced enhancement of viral infections</ET>
<AU>HUISMAN (W.); MARTINA (B. E. E.); RIMMELZWAAN (G. F.); GRUTERS (R. A.); OSTERHAUS (A. D. M. E.)</AU>
<AF>Erasmus MC, Institute of Virology, P.O. Box 1738/3000 DR Rotterdam/Pays-Bas (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2009; Vol. 27; No. 4; Pp. 505-512; Bibl. 128 ref.</SO>
<LA>Anglais</LA>
<EA>Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.</EA>
<CC>002A05F04; 002A05C10</CC>
<FD>Virus immunodéficience humaine; Vaccin; Virose</FD>
<FG>Lentivirus; Retroviridae; Virus; Infection</FG>
<ED>Human immunodeficiency virus; Vaccine; Viral disease</ED>
<EG>Lentivirus; Retroviridae; Virus; Infection</EG>
<SD>Human immunodeficiency virus; Vacuna; Virosis</SD>
<LO>INIST-20289.354000184207870020</LO>
<ID>09-0108127</ID>
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Vaccine-induced enhancement of viral infections

Vaccine-induced enhancement of viral infections

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