Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones
Identifieur interne : 000015 ( PascalFrancis/Corpus ); précédent : 000014; suivant : 000016Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones
Auteurs : KRISHNAN SURESH KUMAR ; Swastika Ganguly ; Ravichandran Veerasamy ; Erik De ClercqSource :
- European journal of medicinal chemistry [ 0223-5234 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Synthèse chimique, Antiviral, Relation structure activité, Composé non nucléoside, Hétérocycle azote, Virus péritonite infectieuse féline, Herpesvirus hominis, Composé bicyclique, Virus vaccine, Virus stomatite vésiculeuse, Composé aromatique, Dérivé du benzène, In vitro, Dérivé de la quinazoline, Quinazolin-4-one dérivé.
English descriptors
- KwdEn :
- Antiviral, Aromatic compound, Benzene derivatives, Bicyclic compound, Chemical synthesis, Feline infectious peritonitis virus, Herpesvirus hominis, In vitro, Nitrogen heterocycle, Non nucleoside compound, Quinazoline derivatives, Structure activity relation, Vaccinia virus, Vesicular stomatitis virus.
Abstract
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
| NO : | PASCAL 11-0128463 INIST |
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| ET : | Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones |
| AU : | KRISHNAN SURESH KUMAR; GANGULY (Swastika); VEERASAMY (Ravichandran); DE CLERCQ (Erik) |
| AF : | Medicinal chemistry research Laboratory, KMCH College of Pharmacy/Coimbatore/Inde (1 aut.); Medicinal chemistry research Laboratory, Department of Pharmaceutical Sciences, Birla Institute of Technology/Ranchi/Inde (2 aut.); Faculty of Pharmacy, AIMST University/Malaisie (3 aut.); Rega Institute for Medical research, Katholieke Universiteit Leuven/3000 Leuven/Belgique (4 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | European journal of medicinal chemistry; ISSN 0223-5234; Coden EJMCA5; Royaume-Uni; Da. 2010; Vol. 45; No. 11; Pp. 5474-5479; Bibl. 20 ref. |
| LA : | Anglais |
| EA : | A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus. |
| CC : | 002B02S05 |
| FD : | Synthèse chimique; Antiviral; Relation structure activité; Composé non nucléoside; Hétérocycle azote; Virus péritonite infectieuse féline; Herpesvirus hominis; Composé bicyclique; Virus vaccine; Virus stomatite vésiculeuse; Composé aromatique; Dérivé du benzène; In vitro; Dérivé de la quinazoline; Quinazolin-4-one dérivé |
| FG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Alphaherpesvirinae; Herpesviridae; Orthopoxvirus; Chordopoxvirinae; Poxviridae; Vesiculovirus; Rhabdoviridae; Mononegavirales |
| ED : | Chemical synthesis; Antiviral; Structure activity relation; Non nucleoside compound; Nitrogen heterocycle; Feline infectious peritonitis virus; Herpesvirus hominis; Bicyclic compound; Vaccinia virus; Vesicular stomatitis virus; Aromatic compound; Benzene derivatives; In vitro; Quinazoline derivatives |
| EG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Alphaherpesvirinae; Herpesviridae; Orthopoxvirus; Chordopoxvirinae; Poxviridae; Vesiculovirus; Rhabdoviridae; Mononegavirales |
| SD : | Síntesis química; Antiviral; Relación estructura actividad; Compuesto no nucleósido; Heterociclo nitrógeno; Feline infectious peritonitis virus; Herpesvirus hominis; Compuesto bicíclico; Vaccinia virus; Vesicular stomatitis virus; Compuesto aromático; Benceno derivado; In vitro |
| LO : | INIST-12640.354000193329240940 |
| ID : | 11-0128463 |
Links to Exploration step
Pascal:11-0128463Le document en format XML
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dérivé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. 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All rights reserved.</s1></fA44><fA45><s0>20 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0128463</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>European journal of medicinal chemistry</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. 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i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Alphaherpesvirinae</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Alphaherpesvirinae</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Alphaherpesvirinae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Herpesviridae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Herpesviridae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Herpesviridae</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Orthopoxvirus</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Orthopoxvirus</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Orthopoxvirus</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Chordopoxvirinae</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Chordopoxvirinae</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Chordopoxvirinae</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Poxviridae</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Poxviridae</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Poxviridae</s0><s2>NW</s2></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Vesiculovirus</s0><s2>NW</s2></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Vesiculovirus</s0><s2>NW</s2></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Vesiculovirus</s0><s2>NW</s2></fC07><fC07 i1="11" i2="X" l="FRE"><s0>Rhabdoviridae</s0><s2>NW</s2></fC07><fC07 i1="11" i2="X" l="ENG"><s0>Rhabdoviridae</s0><s2>NW</s2></fC07><fC07 i1="11" i2="X" l="SPA"><s0>Rhabdoviridae</s0><s2>NW</s2></fC07><fC07 i1="12" i2="X" l="FRE"><s0>Mononegavirales</s0><s2>NW</s2></fC07><fC07 i1="12" i2="X" l="ENG"><s0>Mononegavirales</s0><s2>NW</s2></fC07><fC07 i1="12" i2="X" l="SPA"><s0>Mononegavirales</s0><s2>NW</s2></fC07><fN21><s1>087</s1></fN21></pA></standard><server><NO>PASCAL 11-0128463 INIST</NO><ET>Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones</ET><AU>KRISHNAN SURESH KUMAR; GANGULY (Swastika); VEERASAMY (Ravichandran); DE CLERCQ (Erik)</AU><AF>Medicinal chemistry research Laboratory, KMCH College of Pharmacy/Coimbatore/Inde (1 aut.); Medicinal chemistry research Laboratory, Department of Pharmaceutical Sciences, Birla Institute of Technology/Ranchi/Inde (2 aut.); Faculty of Pharmacy, AIMST University/Malaisie (3 aut.); Rega Institute for Medical research, Katholieke Universiteit Leuven/3000 Leuven/Belgique (4 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>European journal of medicinal chemistry; ISSN 0223-5234; Coden EJMCA5; Royaume-Uni; Da. 2010; Vol. 45; No. 11; Pp. 5474-5479; Bibl. 20 ref.</SO><LA>Anglais</LA><EA>A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.</EA><CC>002B02S05</CC><FD>Synthèse chimique; Antiviral; Relation structure activité; Composé non nucléoside; Hétérocycle azote; Virus péritonite infectieuse féline; Herpesvirus hominis; Composé bicyclique; Virus vaccine; Virus stomatite vésiculeuse; Composé aromatique; Dérivé du benzène; In vitro; Dérivé de la quinazoline; Quinazolin-4-one dérivé</FD><FG>Coronavirus; Coronaviridae; Nidovirales; Virus; Alphaherpesvirinae; Herpesviridae; Orthopoxvirus; Chordopoxvirinae; Poxviridae; Vesiculovirus; Rhabdoviridae; Mononegavirales</FG><ED>Chemical synthesis; Antiviral; Structure activity relation; Non nucleoside compound; Nitrogen heterocycle; Feline infectious peritonitis virus; Herpesvirus hominis; Bicyclic compound; Vaccinia virus; Vesicular stomatitis virus; Aromatic compound; Benzene derivatives; In vitro; Quinazoline derivatives</ED><EG>Coronavirus; Coronaviridae; Nidovirales; Virus; Alphaherpesvirinae; Herpesviridae; Orthopoxvirus; Chordopoxvirinae; Poxviridae; Vesiculovirus; Rhabdoviridae; Mononegavirales</EG><SD>Síntesis química; Antiviral; Relación estructura actividad; Compuesto no nucleósido; Heterociclo nitrógeno; Feline infectious peritonitis virus; Herpesvirus hominis; Compuesto bicíclico; Vaccinia virus; Vesicular stomatitis virus; Compuesto aromático; Benceno derivado; In vitro</SD><LO>INIST-12640.354000193329240940</LO><ID>11-0128463</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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