CovidV2, PascalFrancis, Corpus, bibRecord, 000000

Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection

Identifieur interne : 000000 ( PascalFrancis/Corpus ); suivant : 000001

Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection

Auteurs : Rujvi Kamat ; Gregory G. Brown ; Khalima Bolden ; Christine Fennema-Notestein ; Sarah Archibald ; Thomas D. Marcotte ; Scott L. Letendre ; Ronald J. Ellis ; Steven Paul Woods ; Igor Grant ; Robert K. Heaton

Source :

Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology [ 1380-3395 ] ; 2014.

RBID : Pascal:15-0016983

Descripteurs français

Pascal (Inist)
- Substance blanche, Encéphale, SIDA, Imagerie du tenseur de diffusion, Virus immunodéficience humaine, Cortex préfrontal, Etat dépressif, Homme, Apathie.

English descriptors

KwdEn :
- AIDS, Apathy, Depression, Diffusion tensor imaging, Encephalon, Human, Human immunodeficiency virus, Prefrontal cortex, White matter.

Abstract

Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 15-0016983 INIST
ET :	Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection
AU :	KAMAT (Rujvi); BROWN (Gregory G.); BOLDEN (Khalima); FENNEMA-NOTESTEIN (Christine); ARCHIBALD (Sarah); MARCOTTE (Thomas D.); LETENDRE (Scott L.); ELLIS (Ronald J.); WOODS (Steven Paul); GRANT (Igor); HEATON (Robert K.)
AF :	San Diego University/University of California, San Diego Joint Doctoral Program in Clinical Psychology/San Diego, CA/Etats-Unis (1 aut., 3 aut.); Department of Psychiatry, University of California/San Diego, La Jolla, CA/Etats-Unis (2 aut., 4 aut., 5 aut., 6 aut., 9 aut., 10 aut., 11 aut.); Veterans Administration San Diego Healthcare System/San Diego, CA/Etats-Unis (2 aut.); Department of Medicine, University of California/San Diego, La Jolla, CA/Etats-Unis (7 aut.); Department of Neurosciences, University of California, San Diego, School of Medicine/La Jolla, CA/Etats-Unis (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology; ISSN 1380-3395; Royaume-Uni; Da. 2014; Vol. 36; No. 7-8; Pp. 854-866; Bibl. 2 p.1/4
LA :	Anglais
EA :	Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.
CC :	002B05C02D; 002B18C07A; 002B06D01; 002B18C07D
FD :	Substance blanche; Encéphale; SIDA; Imagerie du tenseur de diffusion; Virus immunodéficience humaine; Cortex préfrontal; Etat dépressif; Homme; Apathie
FG :	Virose; Infection; Lentivirus; Retroviridae; Virus; Système nerveux central; Immunodéficit; Immunopathologie; Trouble de l'humeur
ED :	White matter; Encephalon; AIDS; Diffusion tensor imaging; Human immunodeficiency virus; Prefrontal cortex; Depression; Human; Apathy
EG :	Viral disease; Infection; Lentivirus; Retroviridae; Virus; Central nervous system; Immune deficiency; Immunopathology; Mood disorder
SD :	Substancia blanca; Encéfalo; SIDA; Imágen de tensor de difusión; Human immunodeficiency virus; Corteza prefrontal; Estado depresivo; Hombre; Apatía
LO :	INIST-19365A.354000503561620170
ID :	15-0016983

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Pascal:15-0016983

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection</title>
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<front><div type="abstract" xml:lang="en">Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.</div>
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<ET>Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection</ET>
<AU>KAMAT (Rujvi); BROWN (Gregory G.); BOLDEN (Khalima); FENNEMA-NOTESTEIN (Christine); ARCHIBALD (Sarah); MARCOTTE (Thomas D.); LETENDRE (Scott L.); ELLIS (Ronald J.); WOODS (Steven Paul); GRANT (Igor); HEATON (Robert K.)</AU>
<AF>San Diego University/University of California, San Diego Joint Doctoral Program in Clinical Psychology/San Diego, CA/Etats-Unis (1 aut., 3 aut.); Department of Psychiatry, University of California/San Diego, La Jolla, CA/Etats-Unis (2 aut., 4 aut., 5 aut., 6 aut., 9 aut., 10 aut., 11 aut.); Veterans Administration San Diego Healthcare System/San Diego, CA/Etats-Unis (2 aut.); Department of Medicine, University of California/San Diego, La Jolla, CA/Etats-Unis (7 aut.); Department of Neurosciences, University of California, San Diego, School of Medicine/La Jolla, CA/Etats-Unis (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology; ISSN 1380-3395; Royaume-Uni; Da. 2014; Vol. 36; No. 7-8; Pp. 854-866; Bibl. 2 p.1/4</SO>
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<EA>Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.</EA>
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Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection

Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection

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