Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
Identifieur interne : 001760 ( Ncbi/Merge ); précédent : 001759; suivant : 001761Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
Auteurs : N. Sh. Nadaraia [Géorgie (pays)] ; N. N. Barbakadze [Géorgie (pays)] ; M. L. Kakhabrishvili [Géorgie (pays)] ; B. Sylla ; A. Pichette ; U. S. Makhmudov [Ouzbékistan]Source :
- Chemistry of Natural Compounds [ 0009-3130 ] ; 2018.
Abstract
Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1′-aryl-3′-methyl-5′-androstano[17,16-d]pyrazolines prepared by us earlier.
Url:
DOI: 10.1007/s10600-018-2330-2
PubMed: NONE
PubMed Central: 7087839
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Pichette</name></author><author><name sortKey="Sikharulidze, Mi" uniqKey="Sikharulidze M">MI Sikharulidze</name></author><author><name sortKey="Makhmudov, Us" uniqKey="Makhmudov U">US Makhmudov</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Diffraction, O" uniqKey="Diffraction O">O Diffraction</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheldrick, Gm" uniqKey="Sheldrick G">GM Sheldrick</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chem Nat Compd</journal-id><journal-id journal-id-type="iso-abbrev">Chem Nat Compd</journal-id><journal-title-group><journal-title>Chemistry of Natural Compounds</journal-title></journal-title-group><issn pub-type="ppub">0009-3130</issn><issn pub-type="epub">1573-8388</issn><publisher><publisher-name>Springer US</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7087839</article-id><article-id pub-id-type="publisher-id">2330</article-id><article-id pub-id-type="doi">10.1007/s10600-018-2330-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Synthesis and Biological Activity of Several Modified 5<italic>α</italic>-Androstanolone Derivatives</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Nadaraia</surname><given-names>N. Sh.</given-names></name><address><fax> (99352) 52 00 23</fax><email>nnadaraia@ymail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Barbakadze</surname><given-names>N. N.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kakhabrishvili</surname><given-names>M. L.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sylla</surname><given-names>B.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pichette</surname><given-names>A.</given-names></name><address><fax>(1) 418 545 50 12</fax><email>andre_pichette@uqac.ca</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Makhmudov</surname><given-names>U. S.</given-names></name><address><email>earl-sharp@rambler.ru</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0428 8304</institution-id><institution-id institution-id-type="GRID">grid.412274.6</institution-id><institution>I. Kutateladze Institute of Pharmacochemistry,</institution><institution>Tbilisi State Medical University,</institution></institution-wrap>0159 Tbilisi, Georgia</aff><aff id="Aff2"><label>2</label>LASEVE, Universite Quebec a Chicoutimi, Chicoutimi, QC G7H 2B1 Canada</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2110 259X</institution-id><institution-id institution-id-type="GRID">grid.419209.7</institution-id><institution>S. Yu. Yunusov Institute of the Chemistry of Plant Substances,</institution><institution>Academy of Sciences of the Republic of Uzbekistan,</institution></institution-wrap>Tashkent, Uzbekistan</aff></contrib-group><pub-date pub-type="epub"><day>14</day><month>4</month><year>2018</year></pub-date><pub-date pub-type="ppub"><year>2018</year></pub-date><volume>54</volume><issue>2</issue><fpage>310</fpage><lpage>314</lpage><history><date date-type="received"><day>25</day><month>7</month><year>2017</year></date></history><permissions><copyright-statement>© Springer Science+Business Media, LLC, part of Springer Nature 2018</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1′-aryl-3′-methyl-5′-androstano[17,16-d]pyrazolines prepared by us earlier.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>antiviral activity</kwd><kwd>epiandrosterone</kwd><kwd>modification</kwd><kwd>phenylacetic acid</kwd><kwd>hydrazones</kwd><kwd>pyrazolines</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media, LLC, part of Springer Nature 2018</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Géorgie (pays)</li><li>Ouzbékistan</li></country></list><tree><noCountry><name sortKey="Pichette, A" sort="Pichette, A" uniqKey="Pichette A" first="A." last="Pichette">A. Pichette</name><name sortKey="Sylla, B" sort="Sylla, B" uniqKey="Sylla B" first="B." last="Sylla">B. Sylla</name></noCountry><country name="Géorgie (pays)"><noRegion><name sortKey="Nadaraia, N Sh" sort="Nadaraia, N Sh" uniqKey="Nadaraia N" first="N. Sh." last="Nadaraia">N. Sh. Nadaraia</name></noRegion><name sortKey="Barbakadze, N N" sort="Barbakadze, N N" uniqKey="Barbakadze N" first="N. N." last="Barbakadze">N. N. Barbakadze</name><name sortKey="Kakhabrishvili, M L" sort="Kakhabrishvili, M L" uniqKey="Kakhabrishvili M" first="M. L." last="Kakhabrishvili">M. L. Kakhabrishvili</name></country><country name="Ouzbékistan"><noRegion><name sortKey="Makhmudov, U S" sort="Makhmudov, U S" uniqKey="Makhmudov U" first="U. S." last="Makhmudov">U. S. Makhmudov</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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