Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India
Identifieur interne : 000D68 ( Ncbi/Merge ); précédent : 000D67; suivant : 000D69Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India
Auteurs : Balaji Arvind ; Guruprasad R. Medigeshi ; Arti Kapil ; Immaculata Xess ; Urvashi Singh ; Rakesh Lodha ; Sushil Kumar KabraSource :
- The Indian Journal of Medical Research [ 0971-5916 ] ; 2020.
Abstract
Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF). The infection occurs with a unique spectrum of bacterial pathogens that are usually acquired in an age-dependent fashion. The objective of this study was to find out the aetiological agents in respiratory specimens from children with CF during pulmonary exacerbation and relate with demographic variables.
In this observational study, airway secretions from children (n=104) with CF presenting with pulmonary exacerbations were collected and tested for bacteria, fungi, mycobacteria and viral pathogens using appropriate laboratory techniques. The frequencies of isolation of various organisms were calculated and associated with various demographic profiles.
Bacteria were isolated in 37 (35.5%) and viral RNA in 27 (29.3%) children.
Url:
DOI: 10.4103/ijmr.IJMR_1275_18
PubMed: 32134016
PubMed Central: 7055172
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India</title><author><name sortKey="Arvind, Balaji" sort="Arvind, Balaji" uniqKey="Arvind B" first="Balaji" last="Arvind">Balaji Arvind</name><affiliation><nlm:aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Medigeshi, Guruprasad R" sort="Medigeshi, Guruprasad R" uniqKey="Medigeshi G" first="Guruprasad R." last="Medigeshi">Guruprasad R. Medigeshi</name><affiliation><nlm:aff id="aff3"><italic>Department of Translational Health Science & Technology Institute, Faridabad, Haryana, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kapil, Arti" sort="Kapil, Arti" uniqKey="Kapil A" first="Arti" last="Kapil">Arti Kapil</name><affiliation><nlm:aff id="aff2"><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Xess, Immaculata" sort="Xess, Immaculata" uniqKey="Xess I" first="Immaculata" last="Xess">Immaculata Xess</name><affiliation><nlm:aff id="aff2"><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Singh, Urvashi" sort="Singh, Urvashi" uniqKey="Singh U" first="Urvashi" last="Singh">Urvashi Singh</name><affiliation><nlm:aff id="aff2"><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Lodha, Rakesh" sort="Lodha, Rakesh" uniqKey="Lodha R" first="Rakesh" last="Lodha">Rakesh Lodha</name><affiliation><nlm:aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kabra, Sushil Kumar" sort="Kabra, Sushil Kumar" uniqKey="Kabra S" first="Sushil Kumar" last="Kabra">Sushil Kumar Kabra</name><affiliation><nlm:aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32134016</idno><idno type="pmc">7055172</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055172</idno><idno type="RBID">PMC:7055172</idno><idno type="doi">10.4103/ijmr.IJMR_1275_18</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000880</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000880</idno><idno type="wicri:Area/Pmc/Curation">000880</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000880</idno><idno type="wicri:Area/Pmc/Checkpoint">000209</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000209</idno><idno type="wicri:Area/Ncbi/Merge">000D68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India</title><author><name sortKey="Arvind, Balaji" sort="Arvind, Balaji" uniqKey="Arvind B" first="Balaji" last="Arvind">Balaji Arvind</name><affiliation><nlm:aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Medigeshi, Guruprasad R" sort="Medigeshi, Guruprasad R" uniqKey="Medigeshi G" first="Guruprasad R." last="Medigeshi">Guruprasad R. Medigeshi</name><affiliation><nlm:aff id="aff3"><italic>Department of Translational Health Science & Technology Institute, Faridabad, Haryana, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kapil, Arti" sort="Kapil, Arti" uniqKey="Kapil A" first="Arti" last="Kapil">Arti Kapil</name><affiliation><nlm:aff id="aff2"><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Xess, Immaculata" sort="Xess, Immaculata" uniqKey="Xess I" first="Immaculata" last="Xess">Immaculata Xess</name><affiliation><nlm:aff id="aff2"><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Singh, Urvashi" sort="Singh, Urvashi" uniqKey="Singh U" first="Urvashi" last="Singh">Urvashi Singh</name><affiliation><nlm:aff id="aff2"><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Lodha, Rakesh" sort="Lodha, Rakesh" uniqKey="Lodha R" first="Rakesh" last="Lodha">Rakesh Lodha</name><affiliation><nlm:aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kabra, Sushil Kumar" sort="Kabra, Sushil Kumar" uniqKey="Kabra S" first="Sushil Kumar" last="Kabra">Sushil Kumar Kabra</name><affiliation><nlm:aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">The Indian Journal of Medical Research</title><idno type="ISSN">0971-5916</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background & objectives:</title><p>Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF). The infection occurs with a unique spectrum of bacterial pathogens that are usually acquired in an age-dependent fashion. The objective of this study was to find out the aetiological agents in respiratory specimens from children with CF during pulmonary exacerbation and relate with demographic variables.</p></sec><sec id="st2"><title>Methods:</title><p>In this observational study, airway secretions from children (n=104) with CF presenting with pulmonary exacerbations were collected and tested for bacteria, fungi, mycobacteria and viral pathogens using appropriate laboratory techniques. The frequencies of isolation of various organisms were calculated and associated with various demographic profiles.</p></sec><sec id="st3"><title>Results:</title><p>Bacteria were isolated in 37 (35.5%) and viral RNA in 27 (29.3%) children. <italic>Pseudomonas</italic> was the most common bacteria grown in 31 (29.8%) followed by <italic>Burkholderia cepacia</italic> complex (Bcc) in three (2.8%) patients. Among viruses, Rhinovirus was the most common, identified in 16 (17.4%) samples followed by coronavirus in four (4.3%). Fungi and mycobacteria were isolated from 23 (22.1%) and four (3.8%) children, respectively. <italic>Aspergillus flavus</italic> was the most common fungus isolated in 13 (12.5%) children.</p></sec><sec id="st4"><title>Interpretation & conclusions:</title><p><italic>Pseudomonas</italic> was the most common organism isolated during exacerbation. Non-tuberculous mycobacteria were not isolated, whereas infection with Bcc and <italic>Mycobacterium tuberculosis</italic> was observed, which could probably have a role in CF morbidity. 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Grasemann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Med Res</journal-id><journal-id journal-id-type="iso-abbrev">Indian J. Med. Res</journal-id><journal-id journal-id-type="publisher-id">IJMR</journal-id><journal-title-group><journal-title>The Indian Journal of Medical Research</journal-title></journal-title-group><issn pub-type="ppub">0971-5916</issn><publisher><publisher-name>Wolters Kluwer - Medknow</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32134016</article-id><article-id pub-id-type="pmc">7055172</article-id><article-id pub-id-type="publisher-id">IJMR-151-65</article-id><article-id pub-id-type="doi">10.4103/ijmr.IJMR_1275_18</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arvind</surname><given-names>Balaji</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Medigeshi</surname><given-names>Guruprasad R.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kapil</surname><given-names>Arti</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Xess</surname><given-names>Immaculata</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Singh</surname><given-names>Urvashi</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lodha</surname><given-names>Rakesh</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kabra</surname><given-names>Sushil Kumar</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><label>1</label><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff2"><label>2</label><italic>Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff3"><label>3</label><italic>Department of Translational Health Science & Technology Institute, Faridabad, Haryana, India</italic></aff><author-notes><corresp id="cor1"><italic>For correspondence: </italic> Dr Sushil Kumar Kabra, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110 029, India e-mail: <email xlink:href="skkabra@hotmail.com">skkabra@hotmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2020</year></pub-date><volume>151</volume><issue>1</issue><fpage>65</fpage><lpage>70</lpage><history><date date-type="received"><day>09</day><month>7</month><year>2018</year></date></history><permissions><copyright-statement>Copyright: © 2020 Indian Journal of Medical Research</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0"><license-p>This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>Background & objectives:</title><p>Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF). The infection occurs with a unique spectrum of bacterial pathogens that are usually acquired in an age-dependent fashion. The objective of this study was to find out the aetiological agents in respiratory specimens from children with CF during pulmonary exacerbation and relate with demographic variables.</p></sec><sec id="st2"><title>Methods:</title><p>In this observational study, airway secretions from children (n=104) with CF presenting with pulmonary exacerbations were collected and tested for bacteria, fungi, mycobacteria and viral pathogens using appropriate laboratory techniques. The frequencies of isolation of various organisms were calculated and associated with various demographic profiles.</p></sec><sec id="st3"><title>Results:</title><p>Bacteria were isolated in 37 (35.5%) and viral RNA in 27 (29.3%) children. <italic>Pseudomonas</italic> was the most common bacteria grown in 31 (29.8%) followed by <italic>Burkholderia cepacia</italic> complex (Bcc) in three (2.8%) patients. Among viruses, Rhinovirus was the most common, identified in 16 (17.4%) samples followed by coronavirus in four (4.3%). Fungi and mycobacteria were isolated from 23 (22.1%) and four (3.8%) children, respectively. <italic>Aspergillus flavus</italic> was the most common fungus isolated in 13 (12.5%) children.</p></sec><sec id="st4"><title>Interpretation & conclusions:</title><p><italic>Pseudomonas</italic> was the most common organism isolated during exacerbation. Non-tuberculous mycobacteria were not isolated, whereas infection with Bcc and <italic>Mycobacterium tuberculosis</italic> was observed, which could probably have a role in CF morbidity. Polymicrobial infections were associated with severe exacerbations.</p></sec></abstract><kwd-group><kwd>Acute exacerbation</kwd><kwd>children</kwd><kwd>cystic fibrosis</kwd><kwd>microbiology</kwd><kwd><italic>Pseudomonas</italic></kwd><kwd>polymicrobial infection</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Arvind, Balaji" sort="Arvind, Balaji" uniqKey="Arvind B" first="Balaji" last="Arvind">Balaji Arvind</name><name sortKey="Kabra, Sushil Kumar" sort="Kabra, Sushil Kumar" uniqKey="Kabra S" first="Sushil Kumar" last="Kabra">Sushil Kumar Kabra</name><name sortKey="Kapil, Arti" sort="Kapil, Arti" uniqKey="Kapil A" first="Arti" last="Kapil">Arti Kapil</name><name sortKey="Lodha, Rakesh" sort="Lodha, Rakesh" uniqKey="Lodha R" first="Rakesh" last="Lodha">Rakesh Lodha</name><name sortKey="Medigeshi, Guruprasad R" sort="Medigeshi, Guruprasad R" uniqKey="Medigeshi G" first="Guruprasad R." last="Medigeshi">Guruprasad R. Medigeshi</name><name sortKey="Singh, Urvashi" sort="Singh, Urvashi" uniqKey="Singh U" first="Urvashi" last="Singh">Urvashi Singh</name><name sortKey="Xess, Immaculata" sort="Xess, Immaculata" uniqKey="Xess I" first="Immaculata" last="Xess">Immaculata Xess</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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