Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Identifieur interne : 000B59 ( Ncbi/Merge ); précédent : 000B58; suivant : 000B60Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Auteurs : Weilie Chen [République populaire de Chine] ; Yun Lan [République populaire de Chine] ; Xiaozhen Yuan [République populaire de Chine] ; Xilong Deng [République populaire de Chine] ; Yueping Li [République populaire de Chine] ; Xiaoli Cai [République populaire de Chine] ; Liya Li [République populaire de Chine] ; Ruiying He [République populaire de Chine] ; Yizhou Tan [République populaire de Chine] ; Xizi Deng [République populaire de Chine] ; Ming Gao [République populaire de Chine] ; Guofang Tang [République populaire de Chine] ; Lingzhai Zhao [République populaire de Chine] ; Jinlin Wang [République populaire de Chine] ; Qinghong Fan [République populaire de Chine] ; Chunyan Wen [République populaire de Chine] ; Yuwei Tong [République populaire de Chine] ; Yangbo Tang [République populaire de Chine] ; Fengyu Hu [République populaire de Chine] ; Feng Li [République populaire de Chine] ; Xiaoping Tang [République populaire de Chine]Source :
- Emerging microbes & infections [ 2222-1751 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- génétique : ARN viral.
- sang : ARN viral.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Humains, Indice de gravité médicale, Réaction de polymérisation en chaine en temps réel, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : RNA, Viral.
- genetics : Betacoronavirus, RNA, Viral.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Humans, Real-Time Polymerase Chain Reaction, Retrospective Studies, Severity of Illness Index.
Abstract
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
DOI: 10.1080/22221751.2020.1732837
PubMed: 32102625
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000A10
- to stream PubMed, to step Curation: 000A10
- to stream PubMed, to step Checkpoint: 000787
Links to Exploration step
pubmed:32102625Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.</title>
<author><name sortKey="Chen, Weilie" sort="Chen, Weilie" uniqKey="Chen W" first="Weilie" last="Chen">Weilie Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lan, Yun" sort="Lan, Yun" uniqKey="Lan Y" first="Yun" last="Lan">Yun Lan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yuan, Xiaozhen" sort="Yuan, Xiaozhen" uniqKey="Yuan X" first="Xiaozhen" last="Yuan">Xiaozhen Yuan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Liya" sort="Li, Liya" uniqKey="Li L" first="Liya" last="Li">Liya Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32102625</idno>
<idno type="pmid">32102625</idno>
<idno type="doi">10.1080/22221751.2020.1732837</idno>
<idno type="wicri:Area/PubMed/Corpus">000A10</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A10</idno>
<idno type="wicri:Area/PubMed/Curation">000A10</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A10</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000787</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000787</idno>
<idno type="wicri:Area/Ncbi/Merge">000B59</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.</title>
<author><name sortKey="Chen, Weilie" sort="Chen, Weilie" uniqKey="Chen W" first="Weilie" last="Chen">Weilie Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lan, Yun" sort="Lan, Yun" uniqKey="Lan Y" first="Yun" last="Lan">Yun Lan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yuan, Xiaozhen" sort="Yuan, Xiaozhen" uniqKey="Yuan X" first="Xiaozhen" last="Yuan">Xiaozhen Yuan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Liya" sort="Li, Liya" uniqKey="Li L" first="Liya" last="Li">Liya Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name>
<affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Emerging microbes & infections</title>
<idno type="eISSN">2222-1751</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (genetics)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Coronavirus Infections (virology)</term>
<term>Humans</term>
<term>Pneumonia, Viral (virology)</term>
<term>RNA, Viral (blood)</term>
<term>RNA, Viral (genetics)</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Retrospective Studies</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>ARN viral (sang)</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Infections à coronavirus (virologie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term>
<term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Retrospective Studies</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (<i>p</i>
-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32102625</PMID>
<DateCompleted><Year>2020</Year>
<Month>03</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.</ArticleTitle>
<Pagination><MedlinePgn>469-473</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2020.1732837</ELocationID>
<Abstract><AbstractText>The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (<i>p</i>
-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Weilie</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lan</LastName>
<ForeName>Yun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yuan</LastName>
<ForeName>Xiaozhen</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deng</LastName>
<ForeName>Xilong</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yueping</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cai</LastName>
<ForeName>Xiaoli</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Liya</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Ruiying</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Yizhou</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deng</LastName>
<ForeName>Xizi</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Ming</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Guofang</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Lingzhai</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jinlin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fan</LastName>
<ForeName>Qinghong</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wen</LastName>
<ForeName>Chunyan</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tong</LastName>
<ForeName>Yuwei</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Yangbo</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Fengyu</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Xiaoping</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>02</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">2019-ncov</Keyword>
<Keyword MajorTopicYN="Y">anal swab</Keyword>
<Keyword MajorTopicYN="Y">blood viral RNA</Keyword>
<Keyword MajorTopicYN="Y">laboratory test</Keyword>
<Keyword MajorTopicYN="Y">pharyngeal swab</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>2</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>2</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>3</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32102625</ArticleId>
<ArticleId IdType="doi">10.1080/22221751.2020.1732837</ArticleId>
<ArticleId IdType="pmc">PMC7054964</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nature. 2020 Mar;579(7798):270-273</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32015507</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2018 Apr;556(7700):255-258</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29618817</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 06;43(0):E005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32026671</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2020 Mar 5;382(10):929-936</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32004427</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2020 Mar 17;94(7):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31996437</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Pathol. 2004 Jun;203(2):631-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15141377</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Microbes Infect. 2020 Dec;9(1):313-319</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020836</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2020 Mar;579(7798):265-269</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32015508</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Chen, Weilie" sort="Chen, Weilie" uniqKey="Chen W" first="Weilie" last="Chen">Weilie Chen</name>
</region>
<name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name>
<name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name>
<name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name>
<name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name>
<name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name>
<name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name>
<name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name>
<name sortKey="Lan, Yun" sort="Lan, Yun" uniqKey="Lan Y" first="Yun" last="Lan">Yun Lan</name>
<name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name>
<name sortKey="Li, Liya" sort="Li, Liya" uniqKey="Li L" first="Liya" last="Li">Liya Li</name>
<name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name>
<name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name>
<name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name>
<name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name>
<name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name>
<name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name>
<name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name>
<name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name>
<name sortKey="Yuan, Xiaozhen" sort="Yuan, Xiaozhen" uniqKey="Yuan X" first="Xiaozhen" last="Yuan">Xiaozhen Yuan</name>
<name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B59 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000B59 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:32102625 |texte= Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:32102625" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a CovidV2
![]() | This area was generated with Dilib version V0.6.33. | ![]() |