Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia.
Identifieur interne : 000A07 ( Ncbi/Merge ); précédent : 000A06; suivant : 000A08Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia.
Auteurs : Feng Pan [Royaume-Uni] ; Tianhe Ye [Royaume-Uni] ; Peng Sun [Royaume-Uni] ; Shan Gui [Royaume-Uni] ; Bo Liang [Royaume-Uni] ; Lingli Li [Royaume-Uni] ; Dandan Zheng [Royaume-Uni] ; Jiazheng Wang [Royaume-Uni] ; Richard L. Hesketh [Royaume-Uni] ; Lian Yang [Royaume-Uni] ; Chuansheng Zheng [Royaume-Uni]Source :
- Radiology [ 1527-1315 ] ; 2020.
Abstract
Background Chest CT is used to assess the severity of lung involvement in COVID-19 pneumonia. Purpose To determine the change in chest CT findings associated with COVID-19 pneumonia from initial diagnosis until patient recovery. Materials and Methods This retrospective review included patients with RT-PCR confirmed COVID-19 infection presenting between 12 January 2020 to 6 February 2020. Patients with severe respiratory distress and/ or oxygen requirement at any time during the disease course were excluded. Repeat Chest CT was obtained at approximately 4 day intervals. The total CT score was the sum of lung involvement (5 lobes, score 1-5 for each lobe, range, 0 none, 25 maximum) was determined. Results Twenty one patients (6 males and 15 females, age 25-63 years) with confirmed COVID-19 pneumonia were evaluated. These patients under went a total of 82 pulmonary CT scans with a mean interval of 4±1 days (range: 1-8 days). All patients were discharged after a mean hospitalized period of 17±4 days (range: 11-26 days). Maximum lung involved peaked at approximately 10 days (with the calculated total CT score of 6) from the onset of initial symptoms (R2=0.25), p<0.001). Based on quartiles of patients from day 0 to day 26 involvement, 4 stages of lung CT were defined: Stage 1 (0-4 days): ground glass opacities (GGO) in 18/24 (75%) patients with the total CT score of 2±2; (2)Stage-2 (5-8d days): increased crazy-paving pattern 9/17 patients (53%) with a increase in total CT score (6±4, p=0.002); (3) Stage-3 (9-13days): consolidation 19/21 (91%) patients with the peak of total CT score (7±4); (4) Stage-4 (≥14 days): gradual resolution of consolidation 15/20 (75%) patients with a decreased total CT score (6±4) without crazy-paving pattern. Conclusion In patients recovering from COVID-19 pneumonia (without severe respiratory distress during the disease course), lung abnormalities on chest CT showed greatest severity approximately 10 days after initial onset of symptoms.
DOI: 10.1148/radiol.2020200370
PubMed: 32053470
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia.</title><author><name sortKey="Pan, Feng" sort="Pan, Feng" uniqKey="Pan F" first="Feng" last="Pan">Feng Pan</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Tianhe" sort="Ye, Tianhe" uniqKey="Ye T" first="Tianhe" last="Ye">Tianhe Ye</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Peng" sort="Sun, Peng" uniqKey="Sun P" first="Peng" last="Sun">Peng Sun</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Gui, Shan" sort="Gui, Shan" uniqKey="Gui S" first="Shan" last="Gui">Shan Gui</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Bo" sort="Liang, Bo" uniqKey="Liang B" first="Bo" last="Liang">Bo Liang</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Li, Lingli" sort="Li, Lingli" uniqKey="Li L" first="Lingli" last="Li">Lingli Li</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Dandan" sort="Zheng, Dandan" uniqKey="Zheng D" first="Dandan" last="Zheng">Dandan Zheng</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jiazheng" sort="Wang, Jiazheng" uniqKey="Wang J" first="Jiazheng" last="Wang">Jiazheng Wang</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Hesketh, Richard L" sort="Hesketh, Richard L" uniqKey="Hesketh R" first="Richard L" last="Hesketh">Richard L. Hesketh</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lian" sort="Yang, Lian" uniqKey="Yang L" first="Lian" last="Yang">Lian Yang</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Chuansheng" sort="Zheng, Chuansheng" uniqKey="Zheng C" first="Chuansheng" last="Zheng">Chuansheng Zheng</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32053470</idno><idno type="pmid">32053470</idno><idno type="doi">10.1148/radiol.2020200370</idno><idno type="wicri:Area/PubMed/Corpus">000B52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B52</idno><idno type="wicri:Area/PubMed/Curation">000B52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B52</idno><idno type="wicri:Area/PubMed/Checkpoint">000204</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000204</idno><idno type="wicri:Area/Ncbi/Merge">000A07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia.</title><author><name sortKey="Pan, Feng" sort="Pan, Feng" uniqKey="Pan F" first="Feng" last="Pan">Feng Pan</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Tianhe" sort="Ye, Tianhe" uniqKey="Ye T" first="Tianhe" last="Ye">Tianhe Ye</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Peng" sort="Sun, Peng" uniqKey="Sun P" first="Peng" last="Sun">Peng Sun</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Gui, Shan" sort="Gui, Shan" uniqKey="Gui S" first="Shan" last="Gui">Shan Gui</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Bo" sort="Liang, Bo" uniqKey="Liang B" first="Bo" last="Liang">Bo Liang</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Li, Lingli" sort="Li, Lingli" uniqKey="Li L" first="Lingli" last="Li">Lingli Li</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Dandan" sort="Zheng, Dandan" uniqKey="Zheng D" first="Dandan" last="Zheng">Dandan Zheng</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jiazheng" sort="Wang, Jiazheng" uniqKey="Wang J" first="Jiazheng" last="Wang">Jiazheng Wang</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Hesketh, Richard L" sort="Hesketh, Richard L" uniqKey="Hesketh R" first="Richard L" last="Hesketh">Richard L. Hesketh</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lian" sort="Yang, Lian" uniqKey="Yang L" first="Lian" last="Yang">Lian Yang</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Chuansheng" sort="Zheng, Chuansheng" uniqKey="Zheng C" first="Chuansheng" last="Zheng">Chuansheng Zheng</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</nlm:affiliation><country>Royaume-Uni</country><wicri:regionArea>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU</wicri:regionArea><wicri:noRegion>NW1 2BU</wicri:noRegion></affiliation></author></analytic><series><title level="j">Radiology</title><idno type="eISSN">1527-1315</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Chest CT is used to assess the severity of lung involvement in COVID-19 pneumonia. Purpose To determine the change in chest CT findings associated with COVID-19 pneumonia from initial diagnosis until patient recovery. Materials and Methods This retrospective review included patients with RT-PCR confirmed COVID-19 infection presenting between 12 January 2020 to 6 February 2020. Patients with severe respiratory distress and/ or oxygen requirement at any time during the disease course were excluded. Repeat Chest CT was obtained at approximately 4 day intervals. The total CT score was the sum of lung involvement (5 lobes, score 1-5 for each lobe, range, 0 none, 25 maximum) was determined. Results Twenty one patients (6 males and 15 females, age 25-63 years) with confirmed COVID-19 pneumonia were evaluated. These patients under went a total of 82 pulmonary CT scans with a mean interval of 4±1 days (range: 1-8 days). All patients were discharged after a mean hospitalized period of 17±4 days (range: 11-26 days). Maximum lung involved peaked at approximately 10 days (with the calculated total CT score of 6) from the onset of initial symptoms (R2=0.25), p<0.001). Based on quartiles of patients from day 0 to day 26 involvement, 4 stages of lung CT were defined: Stage 1 (0-4 days): ground glass opacities (GGO) in 18/24 (75%) patients with the total CT score of 2±2; (2)Stage-2 (5-8d days): increased crazy-paving pattern 9/17 patients (53%) with a increase in total CT score (6±4, p=0.002); (3) Stage-3 (9-13days): consolidation 19/21 (91%) patients with the peak of total CT score (7±4); (4) Stage-4 (≥14 days): gradual resolution of consolidation 15/20 (75%) patients with a decreased total CT score (6±4) without crazy-paving pattern. Conclusion In patients recovering from COVID-19 pneumonia (without severe respiratory distress during the disease course), lung abnormalities on chest CT showed greatest severity approximately 10 days after initial onset of symptoms.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32053470</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-1315</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Feb</Month><Day>13</Day></PubDate></JournalIssue><Title>Radiology</Title><ISOAbbreviation>Radiology</ISOAbbreviation></Journal><ArticleTitle>Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia.</ArticleTitle><Pagination><MedlinePgn>200370</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1148/radiol.2020200370</ELocationID><Abstract><AbstractText>Background Chest CT is used to assess the severity of lung involvement in COVID-19 pneumonia. Purpose To determine the change in chest CT findings associated with COVID-19 pneumonia from initial diagnosis until patient recovery. Materials and Methods This retrospective review included patients with RT-PCR confirmed COVID-19 infection presenting between 12 January 2020 to 6 February 2020. Patients with severe respiratory distress and/ or oxygen requirement at any time during the disease course were excluded. Repeat Chest CT was obtained at approximately 4 day intervals. The total CT score was the sum of lung involvement (5 lobes, score 1-5 for each lobe, range, 0 none, 25 maximum) was determined. Results Twenty one patients (6 males and 15 females, age 25-63 years) with confirmed COVID-19 pneumonia were evaluated. These patients under went a total of 82 pulmonary CT scans with a mean interval of 4±1 days (range: 1-8 days). All patients were discharged after a mean hospitalized period of 17±4 days (range: 11-26 days). Maximum lung involved peaked at approximately 10 days (with the calculated total CT score of 6) from the onset of initial symptoms (R2=0.25), p<0.001). Based on quartiles of patients from day 0 to day 26 involvement, 4 stages of lung CT were defined: Stage 1 (0-4 days): ground glass opacities (GGO) in 18/24 (75%) patients with the total CT score of 2±2; (2)Stage-2 (5-8d days): increased crazy-paving pattern 9/17 patients (53%) with a increase in total CT score (6±4, p=0.002); (3) Stage-3 (9-13days): consolidation 19/21 (91%) patients with the peak of total CT score (7±4); (4) Stage-4 (≥14 days): gradual resolution of consolidation 15/20 (75%) patients with a decreased total CT score (6±4) without crazy-paving pattern. Conclusion In patients recovering from COVID-19 pneumonia (without severe respiratory distress during the disease course), lung abnormalities on chest CT showed greatest severity approximately 10 days after initial onset of symptoms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>Feng</ForeName><Initials>F</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2820-768X</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Tianhe</ForeName><Initials>T</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8101-3580</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Peng</ForeName><Initials>P</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9576-6102</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gui</LastName><ForeName>Shan</ForeName><Initials>S</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8165-465X</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Bo</ForeName><Initials>B</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6217-8029</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Lingli</ForeName><Initials>L</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0990-911X</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Dandan</ForeName><Initials>D</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8526-0386</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jiazheng</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1182-442X</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hesketh</LastName><ForeName>Richard L</ForeName><Initials>RL</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8109-0815</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Lian</ForeName><Initials>L</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4664-2474</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Chuansheng</ForeName><Initials>C</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2435-1417</Identifier><AffiliationInfo><Affiliation>From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (F.P., T.Y., S.G., B.L., L.L., L.Y., C.Z); Department of Radiology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China (F.P., T.Y.); Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China (P.S.); Department of Radiology, MSC Clinical& Technical Solutions, Philips Healthcare, Beijing, 100000, China (D.Z., J.W.); Department of Radiology, University College London Hospital, 235, Euston Road, London, NW1 2BU, UK (R.L.H).</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Radiology</MedlineTA><NlmUniqueID>0401260</NlmUniqueID><ISSNLinking>0033-8419</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32053470</ArticleId><ArticleId IdType="doi">10.1148/radiol.2020200370</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Pan, Feng" sort="Pan, Feng" uniqKey="Pan F" first="Feng" last="Pan">Feng Pan</name></noRegion><name sortKey="Gui, Shan" sort="Gui, Shan" uniqKey="Gui S" first="Shan" last="Gui">Shan Gui</name><name sortKey="Hesketh, Richard L" sort="Hesketh, Richard L" uniqKey="Hesketh R" first="Richard L" last="Hesketh">Richard L. Hesketh</name><name sortKey="Li, Lingli" sort="Li, Lingli" uniqKey="Li L" first="Lingli" last="Li">Lingli Li</name><name sortKey="Liang, Bo" sort="Liang, Bo" uniqKey="Liang B" first="Bo" last="Liang">Bo Liang</name><name sortKey="Sun, Peng" sort="Sun, Peng" uniqKey="Sun P" first="Peng" last="Sun">Peng Sun</name><name sortKey="Wang, Jiazheng" sort="Wang, Jiazheng" uniqKey="Wang J" first="Jiazheng" last="Wang">Jiazheng Wang</name><name sortKey="Yang, Lian" sort="Yang, Lian" uniqKey="Yang L" first="Lian" last="Yang">Lian Yang</name><name sortKey="Ye, Tianhe" sort="Ye, Tianhe" uniqKey="Ye T" first="Tianhe" last="Ye">Tianhe Ye</name><name sortKey="Zheng, Chuansheng" sort="Zheng, Chuansheng" uniqKey="Zheng C" first="Chuansheng" last="Zheng">Chuansheng Zheng</name><name sortKey="Zheng, Dandan" sort="Zheng, Dandan" uniqKey="Zheng D" first="Dandan" last="Zheng">Dandan Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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