Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit
Identifieur interne : 000908 ( Ncbi/Merge ); précédent : 000907; suivant : 000909Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit
Auteurs : Vijeta Bajpai ; Ekta Gupta ; Lalita Gauri Mitra ; Hemant Kumar ; Rakhi Maiwall ; Kapil Dev Soni ; Amit GuptaSource :
- Journal of Laboratory Physicians [ 0974-2727 ] ; 2019.
Abstract
Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients.
A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome.
Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral–bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively,
Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome.
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DOI: 10.4103/JLP.JLP_6_19
PubMed: 31929704
PubMed Central: 6943874
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit</title><author><name sortKey="Bajpai, Vijeta" sort="Bajpai, Vijeta" uniqKey="Bajpai V" first="Vijeta" last="Bajpai">Vijeta Bajpai</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gupta, Ekta" sort="Gupta, Ekta" uniqKey="Gupta E" first="Ekta" last="Gupta">Ekta Gupta</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mitra, Lalita Gauri" sort="Mitra, Lalita Gauri" uniqKey="Mitra L" first="Lalita Gauri" last="Mitra">Lalita Gauri Mitra</name><affiliation><nlm:aff id="aff2"><italic>Critical Care and Anaesthesia, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumar, Hemant" sort="Kumar, Hemant" uniqKey="Kumar H" first="Hemant" last="Kumar">Hemant Kumar</name><affiliation><nlm:aff id="aff3"><italic>Pulmonary Medicine, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Maiwall, Rakhi" sort="Maiwall, Rakhi" uniqKey="Maiwall R" first="Rakhi" last="Maiwall">Rakhi Maiwall</name><affiliation><nlm:aff id="aff4"><italic>Hepatology, Institute of Liver and Biliary Sciences, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Soni, Kapil Dev" sort="Soni, Kapil Dev" uniqKey="Soni K" first="Kapil Dev" last="Soni">Kapil Dev Soni</name><affiliation><nlm:aff id="aff5"><italic>Department of Trauma and Critical Intensive Care Unit, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Gupta, Amit" sort="Gupta, Amit" uniqKey="Gupta A" first="Amit" last="Gupta">Amit Gupta</name><affiliation><nlm:aff id="aff6"><italic>Department of Surgery, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31929704</idno><idno type="pmc">6943874</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943874</idno><idno type="RBID">PMC:6943874</idno><idno type="doi">10.4103/JLP.JLP_6_19</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000935</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000935</idno><idno type="wicri:Area/Pmc/Curation">000935</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000935</idno><idno type="wicri:Area/Pmc/Checkpoint">000230</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000230</idno><idno type="wicri:Area/Ncbi/Merge">000908</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit</title><author><name sortKey="Bajpai, Vijeta" sort="Bajpai, Vijeta" uniqKey="Bajpai V" first="Vijeta" last="Bajpai">Vijeta Bajpai</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gupta, Ekta" sort="Gupta, Ekta" uniqKey="Gupta E" first="Ekta" last="Gupta">Ekta Gupta</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mitra, Lalita Gauri" sort="Mitra, Lalita Gauri" uniqKey="Mitra L" first="Lalita Gauri" last="Mitra">Lalita Gauri Mitra</name><affiliation><nlm:aff id="aff2"><italic>Critical Care and Anaesthesia, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumar, Hemant" sort="Kumar, Hemant" uniqKey="Kumar H" first="Hemant" last="Kumar">Hemant Kumar</name><affiliation><nlm:aff id="aff3"><italic>Pulmonary Medicine, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Maiwall, Rakhi" sort="Maiwall, Rakhi" uniqKey="Maiwall R" first="Rakhi" last="Maiwall">Rakhi Maiwall</name><affiliation><nlm:aff id="aff4"><italic>Hepatology, Institute of Liver and Biliary Sciences, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Soni, Kapil Dev" sort="Soni, Kapil Dev" uniqKey="Soni K" first="Kapil Dev" last="Soni">Kapil Dev Soni</name><affiliation><nlm:aff id="aff5"><italic>Department of Trauma and Critical Intensive Care Unit, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Gupta, Amit" sort="Gupta, Amit" uniqKey="Gupta A" first="Amit" last="Gupta">Amit Gupta</name><affiliation><nlm:aff id="aff6"><italic>Department of Surgery, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Laboratory Physicians</title><idno type="ISSN">0974-2727</idno><idno type="eISSN">0974-7826</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>BACKGROUND:</title><p>Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients.</p></sec><sec id="st2"><title>MATERIAL AND METHOD:</title><p>A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome.</p></sec><sec id="st3"><title>RESULTS:</title><p>Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral–bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively, <italic>P</italic> < 0.001).</p></sec><sec id="st4"><title>CONCLUSION:</title><p>Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Ying, S" uniqKey="Ying S">S Ying</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name></author><author><name sortKey="Ge, T" uniqKey="Ge T">T Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viasus, D" uniqKey="Viasus D">D Viasus</name></author><author><name 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Preveden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bajpai, V" uniqKey="Bajpai V">V Bajpai</name></author><author><name sortKey="Gupta, E" uniqKey="Gupta E">E Gupta</name></author><author><name sortKey="Kundu, N" uniqKey="Kundu N">N Kundu</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author><author><name sortKey="Maiwal, R" uniqKey="Maiwal R">R Maiwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Premkumar, M" uniqKey="Premkumar M">M Premkumar</name></author><author><name sortKey="Devurgowda, D" uniqKey="Devurgowda D">D Devurgowda</name></author><author><name sortKey="Dudha, S" uniqKey="Dudha S">S Dudha</name></author><author><name sortKey="Maiwall, R" uniqKey="Maiwall R">R Maiwall</name></author><author><name sortKey="Bihari, C" uniqKey="Bihari C">C Bihari</name></author><author><name sortKey="Grover, S" uniqKey="Grover S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Lab Physicians</journal-id><journal-id journal-id-type="iso-abbrev">J Lab Physicians</journal-id><journal-id journal-id-type="publisher-id">JLP</journal-id><journal-title-group><journal-title>Journal of Laboratory Physicians</journal-title></journal-title-group><issn pub-type="ppub">0974-2727</issn><issn pub-type="epub">0974-7826</issn><publisher><publisher-name>Wolters Kluwer - Medknow</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31929704</article-id><article-id pub-id-type="pmc">6943874</article-id><article-id pub-id-type="publisher-id">JLP-11-356</article-id><article-id pub-id-type="doi">10.4103/JLP.JLP_6_19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bajpai</surname><given-names>Vijeta</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Ekta</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Mitra</surname><given-names>Lalita Gauri</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Hemant</given-names></name><xref ref-type="aff" rid="aff3">2</xref></contrib><contrib contrib-type="author"><name><surname>Maiwall</surname><given-names>Rakhi</given-names></name><xref ref-type="aff" rid="aff4">3</xref></contrib><contrib contrib-type="author"><name><surname>Soni</surname><given-names>Kapil Dev</given-names></name><xref ref-type="aff" rid="aff5">4</xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Amit</given-names></name><xref ref-type="aff" rid="aff6">5</xref></contrib></contrib-group><aff id="aff1"><italic>Departments of Clinical Virology, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff2"><label>1</label><italic>Critical Care and Anaesthesia, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff3"><label>2</label><italic>Pulmonary Medicine, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff4"><label>3</label><italic>Hepatology, Institute of Liver and Biliary Sciences, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff5"><label>4</label><italic>Department of Trauma and Critical Intensive Care Unit, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></aff><aff id="aff6"><label>5</label><italic>Department of Surgery, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Ekta Gupta, Department of Clinical Virology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India. E-mail: <email xlink:href="ektagaurisha@gmail.com">ektagaurisha@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Oct-Dec</season><year>2019</year></pub-date><volume>11</volume><issue>4</issue><fpage>356</fpage><lpage>360</lpage><history><date date-type="received"><day>12</day><month>1</month><year>2019</year></date><date date-type="rev-recd"><day>02</day><month>4</month><year>2019</year></date></history><permissions><copyright-statement>Copyright: © 2019 Journal of Laboratory Physicians</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0"><license-p>This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>BACKGROUND:</title><p>Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients.</p></sec><sec id="st2"><title>MATERIAL AND METHOD:</title><p>A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome.</p></sec><sec id="st3"><title>RESULTS:</title><p>Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral–bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively, <italic>P</italic> < 0.001).</p></sec><sec id="st4"><title>CONCLUSION:</title><p>Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome.</p></sec></abstract><kwd-group><kwd>Care</kwd><kwd>chronic liver disease</kwd><kwd>critical</kwd><kwd>pneumonia</kwd><kwd>respiratory virus</kwd><kwd>unit</kwd><kwd>viral–bacterial coinfection</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bajpai, Vijeta" sort="Bajpai, Vijeta" uniqKey="Bajpai V" first="Vijeta" last="Bajpai">Vijeta Bajpai</name><name sortKey="Gupta, Amit" sort="Gupta, Amit" uniqKey="Gupta A" first="Amit" last="Gupta">Amit Gupta</name><name sortKey="Gupta, Ekta" sort="Gupta, Ekta" uniqKey="Gupta E" first="Ekta" last="Gupta">Ekta Gupta</name><name sortKey="Kumar, Hemant" sort="Kumar, Hemant" uniqKey="Kumar H" first="Hemant" last="Kumar">Hemant Kumar</name><name sortKey="Maiwall, Rakhi" sort="Maiwall, Rakhi" uniqKey="Maiwall R" first="Rakhi" last="Maiwall">Rakhi Maiwall</name><name sortKey="Mitra, Lalita Gauri" sort="Mitra, Lalita Gauri" uniqKey="Mitra L" first="Lalita Gauri" last="Mitra">Lalita Gauri Mitra</name><name sortKey="Soni, Kapil Dev" sort="Soni, Kapil Dev" uniqKey="Soni K" first="Kapil Dev" last="Soni">Kapil Dev Soni</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |