Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
Identifieur interne : 000814 ( Ncbi/Merge ); précédent : 000813; suivant : 000815Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
Auteurs : Lan Li ; Xiaoning Tian ; Jin Chen ; Pengcheng Li ; Qisheng Zheng ; Jibo HouSource :
- Archives of Virology [ 0304-8608 ] ; 2018.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral strategies to control PRRSV are needed. Griffithsin, a red algal lectin, has potent antiviral effect on several human enveloped viruses, but this effect has not been demonstrated on PRRSV. Here, we first tested the
Url:
DOI: 10.1007/s00705-018-4029-x
PubMed: 30220033
PubMed Central: 7087274
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PMC:7087274Le document en format XML
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<series><title level="j">Archives of Virology</title>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral strategies to control PRRSV are needed. Griffithsin, a red algal lectin, has potent antiviral effect on several human enveloped viruses, but this effect has not been demonstrated on PRRSV. Here, we first tested the <italic>in vitro</italic>
antiviral activity of Griffithsin against PRRSV. Griffithsin exerted strong saccharide-dependent antiviral activity against PRRSV, probably through interactions with glycans on the surface of PRRSV that interfered with virus entry. Furthermore we revealed that Griffithsin’s action on PRRSV involved blocking viral adsorption, and it had no effect on viral penetration. Besides Our findings also suggested that Griffithsin may interfere with cell-to-cell spread to prevent virus transmission. The remarkable potency profile of Griffithsin supports its potential value as an antiviral agent against PRRSV.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Arch Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">Arch. Virol</journal-id>
<journal-title-group><journal-title>Archives of Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0304-8608</issn>
<issn pub-type="epub">1432-8798</issn>
<publisher><publisher-name>Springer Vienna</publisher-name>
<publisher-loc>Vienna</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30220033</article-id>
<article-id pub-id-type="pmc">7087274</article-id>
<article-id pub-id-type="publisher-id">4029</article-id>
<article-id pub-id-type="doi">10.1007/s00705-018-4029-x</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection <italic>in vitro</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Li</surname>
<given-names>Lan</given-names>
</name>
<address><email>lanli99@foxmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Tian</surname>
<given-names>Xiaoning</given-names>
</name>
<address><email>15733223151@163.com</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Jin</given-names>
</name>
<address><email>chenjin_abc@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Pengcheng</given-names>
</name>
<address><email>lipengcheng305@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zheng</surname>
<given-names>Qisheng</given-names>
</name>
<address><email>njcvc1302@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Hou</surname>
<given-names>Jibo</given-names>
</name>
<address><email>houjiboccvv@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id>
<institution-id institution-id-type="GRID">grid.454840.9</institution-id>
<institution>National Research, Center of Engineering and Technology for Veterinary Biologicals,</institution>
<institution>Jiangsu Academy of Agricultural Sciences,</institution>
</institution-wrap>
Nanjing, 210014 Jiangsu People’s Republic of China</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9750 7019</institution-id>
<institution-id institution-id-type="GRID">grid.27871.3b</institution-id>
<institution>College of Veterinary Medicine,</institution>
<institution>Nanjing Agricultural University,</institution>
</institution-wrap>
Nanjing, 210095 Jiangsu People’s Republic of China</aff>
<aff id="Aff3"><label>3</label>
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009 Jiangsu People’s Republic of China</aff>
</contrib-group>
<author-notes><fn fn-type="com"><p>Handling Editor: Zhenhai Chen.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>15</day>
<month>9</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="ppub"><year>2018</year>
</pub-date>
<volume>163</volume>
<issue>12</issue>
<fpage>3317</fpage>
<lpage>3325</lpage>
<history><date date-type="received"><day>18</day>
<month>5</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>1</day>
<month>8</month>
<year>2018</year>
</date>
</history>
<permissions><copyright-statement>© Springer-Verlag GmbH Austria, part of Springer Nature 2018</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral strategies to control PRRSV are needed. Griffithsin, a red algal lectin, has potent antiviral effect on several human enveloped viruses, but this effect has not been demonstrated on PRRSV. Here, we first tested the <italic>in vitro</italic>
antiviral activity of Griffithsin against PRRSV. Griffithsin exerted strong saccharide-dependent antiviral activity against PRRSV, probably through interactions with glycans on the surface of PRRSV that interfered with virus entry. Furthermore we revealed that Griffithsin’s action on PRRSV involved blocking viral adsorption, and it had no effect on viral penetration. Besides Our findings also suggested that Griffithsin may interfere with cell-to-cell spread to prevent virus transmission. The remarkable potency profile of Griffithsin supports its potential value as an antiviral agent against PRRSV.</p>
</abstract>
<funding-group><award-group><funding-source><institution>the Special Fund for Agro-scientific Research in the Public Interest</institution>
</funding-source>
<award-id>No. 201303046</award-id>
<principal-award-recipient><name><surname>Hou</surname>
<given-names>Jibo</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer-Verlag GmbH Austria, part of Springer Nature 2018</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name>
<name sortKey="Hou, Jibo" sort="Hou, Jibo" uniqKey="Hou J" first="Jibo" last="Hou">Jibo Hou</name>
<name sortKey="Li, Lan" sort="Li, Lan" uniqKey="Li L" first="Lan" last="Li">Lan Li</name>
<name sortKey="Li, Pengcheng" sort="Li, Pengcheng" uniqKey="Li P" first="Pengcheng" last="Li">Pengcheng Li</name>
<name sortKey="Tian, Xiaoning" sort="Tian, Xiaoning" uniqKey="Tian X" first="Xiaoning" last="Tian">Xiaoning Tian</name>
<name sortKey="Zheng, Qisheng" sort="Zheng, Qisheng" uniqKey="Zheng Q" first="Qisheng" last="Zheng">Qisheng Zheng</name>
</noCountry>
</tree>
</affiliations>
</record>
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