Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM.
Identifieur interne : 000818 ( Ncbi/Curation ); précédent : 000817; suivant : 000819Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM.
Auteurs : R. Dörries ; R. Watanabe ; H. Wege ; V. Ter MeulenSource :
- Journal of neuroimmunology [ 0165-5728 ] ; 1987.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Encéphalomyélite.
- immunologie : Encéphalomyélite, Maladies démyélinisantes, Virus de l'hépatite murine.
- Albumines, Animaux, Anticorps antiviraux, Barrière hémato-encéphalique, Immunoglobulines, Rats, Rats de lignée BN.
English descriptors
- KwdEn :
- Albumins (cerebrospinal fluid), Animals, Antibodies, Viral (cerebrospinal fluid), Blood-Brain Barrier, Demyelinating Diseases (immunology), Encephalomyelitis (immunology), Encephalomyelitis (pathology), Immunoglobulins (cerebrospinal fluid), Murine hepatitis virus (immunology), Rats, Rats, Inbred BN.
- MESH :
- chemical , cerebrospinal fluid : Albumins, Antibodies, Viral, Immunoglobulins.
- immunology : Demyelinating Diseases, Encephalomyelitis, Murine hepatitis virus.
- pathology : Encephalomyelitis.
- Animals, Blood-Brain Barrier, Rats, Rats, Inbred BN.
Abstract
Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.
DOI: 10.1016/0165-5728(87)90017-8
PubMed: 3031130
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pubmed:3031130Le document en format XML
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Dörries</name></author><author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. 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Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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