Evaluation of infliximab as second-line treatment of acute graft versus host disease -validating response on day 7 and 28 as predictors of survival
Identifieur interne : 000767 ( Ncbi/Checkpoint ); précédent : 000766; suivant : 000768Evaluation of infliximab as second-line treatment of acute graft versus host disease -validating response on day 7 and 28 as predictors of survival
Auteurs : Marietta Nygaard [Danemark] ; Niels Smedegaard Andersen [Danemark] ; Claus Ernst Moser [Danemark] ; Gitte Olesen [Danemark] ; Ida Marie Schj Dt [Danemark] ; Carsten Heilmann [Danemark] ; Henrik Sengel V [Danemark]Source :
- Bone Marrow Transplantation [ 0268-3369 ] ; 2018.
Abstract
Several immunosuppressive drugs have been proposed for second-line treatment of steroid-refractory acute graft versus host disease (aGvHD) after allogeneic hematopoietic stem cell transplantation. However, the studies on these drugs are small, retrospective, uncontrolled and use different endpoints. Therefore, it remains unknown which treatment is superior. We retrospectively evaluated 68 consecutive patients treated with infliximab for aGvHD. We adhered to recently proposed guidelines for aGvHD trials and thus evaluated response on day 7 and 28. Furthermore, we assessed the composite endpoint 6 months freedom from treatment failure (6MFTF). The majority of patients had grade III-IV aGvHD. We found that 41 patients (60%) responded on day 7 and 31 patients (46%) on day 28. Twenty-four patients (35%) achieved 6MFTF. The main reasons for failure within 6 months were death (
Url:
DOI: 10.1038/s41409-018-0099-3
PubMed: 29391524
PubMed Central: 7086567
Affiliations:
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<series><title level="j">Bone Marrow Transplantation</title>
<idno type="ISSN">0268-3369</idno>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Several immunosuppressive drugs have been proposed for second-line treatment of steroid-refractory acute graft versus host disease (aGvHD) after allogeneic hematopoietic stem cell transplantation. However, the studies on these drugs are small, retrospective, uncontrolled and use different endpoints. Therefore, it remains unknown which treatment is superior. We retrospectively evaluated 68 consecutive patients treated with infliximab for aGvHD. We adhered to recently proposed guidelines for aGvHD trials and thus evaluated response on day 7 and 28. Furthermore, we assessed the composite endpoint 6 months freedom from treatment failure (6MFTF). The majority of patients had grade III-IV aGvHD. We found that 41 patients (60%) responded on day 7 and 31 patients (46%) on day 28. Twenty-four patients (35%) achieved 6MFTF. The main reasons for failure within 6 months were death (<italic>n</italic>
= 31) or additional immunosuppression (<italic>n</italic>
= 16). By six and 24 months, 44 and 34% of the patients were alive respectively. Patients with response to infliximab on day 7 and 28 had significantly higher overall survival (OS) probability than non-responders. We show that response on day 7 and 28 identifies high and low risk groups. Patients who fail to respond should be identified early and offered alternative therapy.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Martin, Pj" uniqKey="Martin P">PJ Martin</name>
</author>
<author><name sortKey="Rizzo, Jd" uniqKey="Rizzo J">JD Rizzo</name>
</author>
<author><name sortKey="Wingard, Jr" uniqKey="Wingard J">JR Wingard</name>
</author>
<author><name sortKey="Ballen, K" uniqKey="Ballen K">K Ballen</name>
</author>
<author><name sortKey="Curtin, Pt" uniqKey="Curtin P">PT Curtin</name>
</author>
<author><name sortKey="Cutler, C" uniqKey="Cutler C">C Cutler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Pj" uniqKey="Martin P">PJ Martin</name>
</author>
<author><name sortKey="Inamoto, Y" uniqKey="Inamoto Y">Y Inamoto</name>
</author>
<author><name sortKey="Flowers, Med" uniqKey="Flowers M">MED Flowers</name>
</author>
<author><name sortKey="Carpenter, Pa" uniqKey="Carpenter P">PA Carpenter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Pj" uniqKey="Martin P">PJ Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Pj" uniqKey="Martin P">PJ Martin</name>
</author>
<author><name sortKey="Bachier, Cr" uniqKey="Bachier C">CR Bachier</name>
</author>
<author><name sortKey="Klingemann, Hg" uniqKey="Klingemann H">HG Klingemann</name>
</author>
<author><name sortKey="Mccarthy, Pl" uniqKey="Mccarthy P">PL McCarthy</name>
</author>
<author><name sortKey="Szabolcs, P" uniqKey="Szabolcs P">P Szabolcs</name>
</author>
<author><name sortKey="Uberti, Jp" uniqKey="Uberti J">JP Uberti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sengsayadeth, S" uniqKey="Sengsayadeth S">S Sengsayadeth</name>
</author>
<author><name sortKey="Savani, Bn" uniqKey="Savani B">BN Savani</name>
</author>
<author><name sortKey="Jagasia, M" uniqKey="Jagasia M">M Jagasia</name>
</author>
<author><name sortKey="Goodman, S" uniqKey="Goodman S">S Goodman</name>
</author>
<author><name sortKey="Greer, Jp" uniqKey="Greer J">JP Greer</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inamoto, Y" uniqKey="Inamoto Y">Y Inamoto</name>
</author>
<author><name sortKey="Martin, Pj" uniqKey="Martin P">PJ Martin</name>
</author>
<author><name sortKey="Storer, Be" uniqKey="Storer B">BE Storer</name>
</author>
<author><name sortKey="Mielcarek, M" uniqKey="Mielcarek M">M Mielcarek</name>
</author>
<author><name sortKey="Storb, Rf" uniqKey="Storb R">RF Storb</name>
</author>
<author><name sortKey="Carpenter, Pa" uniqKey="Carpenter P">PA Carpenter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Remberger, M" uniqKey="Remberger M">M Remberger</name>
</author>
<author><name sortKey="Ringden, O" uniqKey="Ringden O">O Ringden</name>
</author>
<author><name sortKey="Markling, L" uniqKey="Markling L">L Markling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Korngold, R" uniqKey="Korngold R">R Korngold</name>
</author>
<author><name sortKey="Marini, Jc" uniqKey="Marini J">JC Marini</name>
</author>
<author><name sortKey="De, Bacame" uniqKey="De B">BacaME De</name>
</author>
<author><name sortKey="Murphy, Gf" uniqKey="Murphy G">GF Murphy</name>
</author>
<author><name sortKey="Giles Komar, J" uniqKey="Giles Komar J">J Giles-komar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choi, Sw" uniqKey="Choi S">SW Choi</name>
</author>
<author><name sortKey="Stiff, P" uniqKey="Stiff P">P Stiff</name>
</author>
<author><name sortKey="Cooke, K" uniqKey="Cooke K">K Cooke</name>
</author>
<author><name sortKey="Ferrara, Jlm" uniqKey="Ferrara J">JLM Ferrara</name>
</author>
<author><name sortKey="Braun, T" uniqKey="Braun T">T Braun</name>
</author>
<author><name sortKey="Kitko, C" uniqKey="Kitko C">C Kitko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamadani, M" uniqKey="Hamadani M">M Hamadani</name>
</author>
<author><name sortKey="Hofmeister, Cc" uniqKey="Hofmeister C">CC Hofmeister</name>
</author>
<author><name sortKey="Jansak, B" uniqKey="Jansak B">B Jansak</name>
</author>
<author><name sortKey="Phillips, G" uniqKey="Phillips G">G Phillips</name>
</author>
<author><name sortKey="Elder, P" uniqKey="Elder P">P Elder</name>
</author>
<author><name sortKey="Blum, W" uniqKey="Blum W">W Blum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alousi, Am" uniqKey="Alousi A">AM Alousi</name>
</author>
<author><name sortKey="Weisdorf, Dj" uniqKey="Weisdorf D">DJ Weisdorf</name>
</author>
<author><name sortKey="Logan, Br" uniqKey="Logan B">BR Logan</name>
</author>
<author><name sortKey="Bolan, J" uniqKey="Bolan J">J Bolan</name>
</author>
<author><name sortKey="Carter, S" uniqKey="Carter S">S Carter</name>
</author>
<author><name sortKey="Difronzo, N" uniqKey="Difronzo N">N Difronzo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uberti, Jp" uniqKey="Uberti J">JP Uberti</name>
</author>
<author><name sortKey="Ayash, L" uniqKey="Ayash L">L Ayash</name>
</author>
<author><name sortKey="Ratanatharathorn, V" uniqKey="Ratanatharathorn V">V Ratanatharathorn</name>
</author>
<author><name sortKey="Silver, S" uniqKey="Silver S">S Silver</name>
</author>
<author><name sortKey="Reynolds, C" uniqKey="Reynolds C">C Reynolds</name>
</author>
<author><name sortKey="Becker, M" uniqKey="Becker M">M Becker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, Je" uniqKey="Levine J">JE Levine</name>
</author>
<author><name sortKey="Paczesny, S" uniqKey="Paczesny S">S Paczesny</name>
</author>
<author><name sortKey="Mineishi, S" uniqKey="Mineishi S">S Mineishi</name>
</author>
<author><name sortKey="Braun, T" uniqKey="Braun T">T Braun</name>
</author>
<author><name sortKey="Choi, Sw" uniqKey="Choi S">SW Choi</name>
</author>
<author><name sortKey="Hutchinson, Rj" uniqKey="Hutchinson R">RJ Hutchinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Couriel, Dr" uniqKey="Couriel D">DR Couriel</name>
</author>
<author><name sortKey="Saliba, R" uniqKey="Saliba R">R Saliba</name>
</author>
<author><name sortKey="De Lima, M" uniqKey="De Lima M">M de Lima</name>
</author>
<author><name sortKey="Giralt, S" uniqKey="Giralt S">S Giralt</name>
</author>
<author><name sortKey="Andersson, B" uniqKey="Andersson B">B Andersson</name>
</author>
<author><name sortKey="Khouri, I" uniqKey="Khouri I">I Khouri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gatza, E" uniqKey="Gatza E">E Gatza</name>
</author>
<author><name sortKey="Braun, T" uniqKey="Braun T">T Braun</name>
</author>
<author><name sortKey="Levine, Je" uniqKey="Levine J">JE Levine</name>
</author>
<author><name sortKey="Ferrara, Jlm" uniqKey="Ferrara J">JLM Ferrara</name>
</author>
<author><name sortKey="Zhao, S" uniqKey="Zhao S">S Zhao</name>
</author>
<author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kobbe, G" uniqKey="Kobbe G">G Kobbe</name>
</author>
<author><name sortKey="Schneider, P" uniqKey="Schneider P">P Schneider</name>
</author>
<author><name sortKey="Rohr, U" uniqKey="Rohr U">U Rohr</name>
</author>
<author><name sortKey="Fenk, R" uniqKey="Fenk R">R Fenk</name>
</author>
<author><name sortKey="Neumann, F" uniqKey="Neumann F">F Neumann</name>
</author>
<author><name sortKey="Aivado, M" uniqKey="Aivado M">M Aivado</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rivkina, Am" uniqKey="Rivkina A">AM Rivkina</name>
</author>
<author><name sortKey="Stump, Ls" uniqKey="Stump L">LS Stump</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamane, T" uniqKey="Yamane T">T Yamane</name>
</author>
<author><name sortKey="Yamamura, R" uniqKey="Yamamura R">R Yamamura</name>
</author>
<author><name sortKey="Aoyama, Y" uniqKey="Aoyama Y">Y Aoyama</name>
</author>
<author><name sortKey="Nakamae, H" uniqKey="Nakamae H">H Nakamae</name>
</author>
<author><name sortKey="Hasegawa, T" uniqKey="Hasegawa T">T Hasegawa</name>
</author>
<author><name sortKey="Sakamoto, C" uniqKey="Sakamoto C">C Sakamoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patriarca, F" uniqKey="Patriarca F">F Patriarca</name>
</author>
<author><name sortKey="Sperotto, A" uniqKey="Sperotto A">A Sperotto</name>
</author>
<author><name sortKey="Damiani, D" uniqKey="Damiani D">D Damiani</name>
</author>
<author><name sortKey="Morreale, G" uniqKey="Morreale G">G Morreale</name>
</author>
<author><name sortKey="Bonifazi, F" uniqKey="Bonifazi F">F Bonifazi</name>
</author>
<author><name sortKey="Olivieri, A" uniqKey="Olivieri A">A Olivieri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Couriel, D" uniqKey="Couriel D">D Couriel</name>
</author>
<author><name sortKey="Saliba, R" uniqKey="Saliba R">R Saliba</name>
</author>
<author><name sortKey="Hicks, K" uniqKey="Hicks K">K Hicks</name>
</author>
<author><name sortKey="Ippoliti, C" uniqKey="Ippoliti C">C Ippoliti</name>
</author>
<author><name sortKey="De Lima, M" uniqKey="De Lima M">M de Lima</name>
</author>
<author><name sortKey="Hosing, C" uniqKey="Hosing C">C Hosing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sleight, Bs" uniqKey="Sleight B">BS Sleight</name>
</author>
<author><name sortKey="Chan, Kw" uniqKey="Chan K">KW Chan</name>
</author>
<author><name sortKey="Braun, Tm" uniqKey="Braun T">TM Braun</name>
</author>
<author><name sortKey="Serrano, A" uniqKey="Serrano A">A Serrano</name>
</author>
<author><name sortKey="Gilman, Al" uniqKey="Gilman A">AL Gilman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pidala, J" uniqKey="Pidala J">J Pidala</name>
</author>
<author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name>
</author>
<author><name sortKey="Field, T" uniqKey="Field T">T Field</name>
</author>
<author><name sortKey="Mcbride, A" uniqKey="Mcbride A">A McBride</name>
</author>
<author><name sortKey="Kharfan Dabaja, M" uniqKey="Kharfan Dabaja M">M Kharfan-Dabaja</name>
</author>
<author><name sortKey="Perkins, J" uniqKey="Perkins J">J Perkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rao, K" uniqKey="Rao K">K Rao</name>
</author>
<author><name sortKey="Rao, A" uniqKey="Rao A">A Rao</name>
</author>
<author><name sortKey="Karlsson, H" uniqKey="Karlsson H">H Karlsson</name>
</author>
<author><name sortKey="Jagani, M" uniqKey="Jagani M">M Jagani</name>
</author>
<author><name sortKey="Veys, P" uniqKey="Veys P">P Veys</name>
</author>
<author><name sortKey="Amrolia, Pj" uniqKey="Amrolia P">PJ Amrolia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Cheuk, Dkl" uniqKey="Cheuk D">DKL Cheuk</name>
</author>
<author><name sortKey="Ha, Sy" uniqKey="Ha S">SY Ha</name>
</author>
<author><name sortKey="Chiang, Aks" uniqKey="Chiang A">AKS Chiang</name>
</author>
<author><name sortKey="Lee, Tl" uniqKey="Lee T">TL Lee</name>
</author>
<author><name sortKey="Ho, Mhk" uniqKey="Ho M">MHK Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Przepiorka, D" uniqKey="Przepiorka D">D Przepiorka</name>
</author>
<author><name sortKey="Weisdorf, D" uniqKey="Weisdorf D">D Weisdorf</name>
</author>
<author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name>
</author>
<author><name sortKey="Klingemann, Hg" uniqKey="Klingemann H">HG Klingemann</name>
</author>
<author><name sortKey="Beatty, P" uniqKey="Beatty P">P Beatty</name>
</author>
<author><name sortKey="Hows, J" uniqKey="Hows J">J Hows</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macmillan, Ml" uniqKey="Macmillan M">ML MacMillan</name>
</author>
<author><name sortKey="Defor, Te" uniqKey="Defor T">TE DeFor</name>
</author>
<author><name sortKey="Weisdorf, Dj" uniqKey="Weisdorf D">DJ Weisdorf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saliba, Rm" uniqKey="Saliba R">RM Saliba</name>
</author>
<author><name sortKey="Couriel, Dr" uniqKey="Couriel D">DR Couriel</name>
</author>
<author><name sortKey="Giralt, S" uniqKey="Giralt S">S Giralt</name>
</author>
<author><name sortKey="Rondon, G" uniqKey="Rondon G">G Rondon</name>
</author>
<author><name sortKey="Okoroji, Gj" uniqKey="Okoroji G">GJ Okoroji</name>
</author>
<author><name sortKey="Rashid, A" uniqKey="Rashid A">A Rashid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, Je" uniqKey="Levine J">JE Levine</name>
</author>
<author><name sortKey="Logan, B" uniqKey="Logan B">B Logan</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Alousi, Am" uniqKey="Alousi A">AM Alousi</name>
</author>
<author><name sortKey="Ho, V" uniqKey="Ho V">V Ho</name>
</author>
<author><name sortKey="Bola Os Meade, J" uniqKey="Bola Os Meade J">J Bolaños-Meade</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marty, Fm" uniqKey="Marty F">FM Marty</name>
</author>
<author><name sortKey="Lee, Sj" uniqKey="Lee S">SJ Lee</name>
</author>
<author><name sortKey="Fahey, Mm" uniqKey="Fahey M">MM Fahey</name>
</author>
<author><name sortKey="Alyea, Ep" uniqKey="Alyea E">EP Alyea</name>
</author>
<author><name sortKey="Soiffer, Rj" uniqKey="Soiffer R">RJ Soiffer</name>
</author>
<author><name sortKey="Antin, Jh" uniqKey="Antin J">JH Antin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Cadenas, I" uniqKey="Garcia Cadenas I">I García-Cadenas</name>
</author>
<author><name sortKey="Rivera, I" uniqKey="Rivera I">I Rivera</name>
</author>
<author><name sortKey="Martino, R" uniqKey="Martino R">R Martino</name>
</author>
<author><name sortKey="Esquirol, A" uniqKey="Esquirol A">A Esquirol</name>
</author>
<author><name sortKey="Barba, P" uniqKey="Barba P">P Barba</name>
</author>
<author><name sortKey="Novelli, S" uniqKey="Novelli S">S Novelli</name>
</author>
</analytic>
</biblStruct>
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<tree><country name="Danemark"><noRegion><name sortKey="Nygaard, Marietta" sort="Nygaard, Marietta" uniqKey="Nygaard M" first="Marietta" last="Nygaard">Marietta Nygaard</name>
</noRegion>
<name sortKey="Andersen, Niels Smedegaard" sort="Andersen, Niels Smedegaard" uniqKey="Andersen N" first="Niels Smedegaard" last="Andersen">Niels Smedegaard Andersen</name>
<name sortKey="Heilmann, Carsten" sort="Heilmann, Carsten" uniqKey="Heilmann C" first="Carsten" last="Heilmann">Carsten Heilmann</name>
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<name sortKey="Schj Dt, Ida Marie" sort="Schj Dt, Ida Marie" uniqKey="Schj Dt I" first="Ida Marie" last="Schj Dt">Ida Marie Schj Dt</name>
<name sortKey="Sengel V, Henrik" sort="Sengel V, Henrik" uniqKey="Sengel V H" first="Henrik" last="Sengel V">Henrik Sengel V</name>
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