CovidV2, Ncbi, Checkpoint, bibRecord, 000048

Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus

Identifieur interne : 000048 ( Ncbi/Checkpoint ); précédent : 000047; suivant : 000049

Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus

Auteurs : X. W. Zhang [République populaire de Chine] ; Y. L. Yap [République populaire de Chine] ; A. Danchin [France]

Source :

Archives of Virology [ 0304-8608 ] ; 2004.

RBID : PMC:7087341

Descripteurs français

KwdFr :
- Alignement de séquences, Bases de données génétiques, Biologie informatique, Coronavirus (génétique), Coronavirus (physiologie), Génome viral, Phylogénie, Recombinaison génétique, Similitude de séquences d'acides aminés, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Virus du SRAS (physiologie).
MESH :
- génétique : Coronavirus, Virus du SRAS.
- physiologie : Coronavirus, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Alignement de séquences, Bases de données génétiques, Biologie informatique, Génome viral, Phylogénie, Recombinaison génétique, Similitude de séquences d'acides aminés.

English descriptors

KwdEn :
- Computational Biology, Coronavirus (genetics), Coronavirus (physiology), Databases, Genetic, Genome, Viral, Phylogeny, Recombination, Genetic, SARS Virus (genetics), SARS Virus (physiology), Sequence Alignment, Sequence Homology, Amino Acid, Severe Acute Respiratory Syndrome (virology).
MESH :
- genetics : Coronavirus, SARS Virus.
- physiology : Coronavirus, SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Computational Biology, Databases, Genetic, Genome, Viral, Phylogeny, Recombination, Genetic, Sequence Alignment, Sequence Homology, Amino Acid.

Abstract

Summary.

The origin of severe acute respiratory syndrome-associated corona-virus (SARS-CoV) is still a matter of speculation, although more than one year has passed since the onset of the SARS outbreak. In this study, we implemented a 3-step strategy to test the intriguing hypothesis that SARS-CoV might have been derived from a recombinant virus. First, we blasted the whole SARS-CoV genome against a virus database to search viruses of interest. Second, we employed 7 recombination detection techniques well documented in successfully detecting recombination events to explore the presence of recombination in SARS-CoV genome. Finally, we conducted phylogenetic analyses to further explore whether recombination has indeed occurred in the course of coronaviruses history predating the emergence of SARS-CoV. Surprisingly, we found that 7 putative recombination regions, located in Replicase 1ab and Spike protein, exist between SARS-CoV and other 6 coronaviruses: porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), bovine coronavirus (BCoV), human coronavirus 229E (HCoV), murine hepatitis virus (MHV), and avian infectious bronchitis virus (IBV). Thus, our analyses substantiate the presence of recombination events in history that led to the SARS-CoV genome. Like the other coronaviruses used in the analysis, SARS-CoV is also a mosaic structure.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087341

DOI: 10.1007/s00705-004-0413-9
PubMed: 15480857
PubMed Central: 7087341

Affiliations:

France, République populaire de Chine

Links to Exploration step

PMC:7087341

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Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus

Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Covid (26 mars)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.