Response of genetically susceptible and resistant mice to intranasal inoculation with mouse hepatitis virus JHM
Identifieur interne : 001D29 ( Main/Merge ); précédent : 001D28; suivant : 001D30Response of genetically susceptible and resistant mice to intranasal inoculation with mouse hepatitis virus JHM
Auteurs : Stephen W. Barthold [États-Unis] ; Abigail L. Smith [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 1987.
English descriptors
- Teeft :
- Additional group, Additional groups, Animal room, Antibody titers, Balb, Balb mice, Barthold, Bone marrow, Brain infection, Demyelination, Detectable virus, Different organs, Encephalitic signs, Encephalitis, Enterotropic mouse hepatitis virus infection, Enzyme immunoassay, Extensive destruction, Genotype, Goto, Hematogenous infection, Hepatitis, Host genotype, Ileal wall, Infectious virus, Inoculated, Inoculation, Intestinal virus titers, Intestine, Intranasal inoculation, Knobler, Lesion, Lymph nodes, Lymphoid, Lymphoid tissue, Lymphoid tissues, Mesenteric lymph node, Mice inoculated, Milder disease, More mice, Mouse, Mouse hepatitis, Mouse hepatitis virus, Mouse hepatitis virus infection, Mouse hepatitis virus strain, Mouse hepatitis virus type, Murine, Murine coronavirus, Murine virus, Mutant, Nasal mucosa, Nervous system disease, Node, Older mice, Olfactory, Olfactory bulb, Olfactory bulbs, Other intervals, Other organs, Present study, Resistant mice, Rodent coronaviruses, Salivary glands, Significant differences, Small intestine, Spinal cord, Spleen, Stohlman, Suckling mice, Taguchi, Target tissues, Tissue resistance, Titer, Viral, Viral antigen, Virus, Virus activity, Virus quantification, Virus strain, Virus titers, Wild type.
Abstract
Abstract: Mouse hepatitis virus (MHV)-JHM infection was studied in genetically susceptible (BALB/cByJ) and resistant (SJL/J) mice following intranasal inoculation at 1, 3, 6 or 12 wk of age. Markers of infection included histology, immunohistochemistry, virus quantification and virus serology. All BALE mice developed severe disseminated disease with high mortality due to encephalitis and hepatitis. Peak MHV titers appeared in brain, liver, spleen and intestine on days 3 or 5. Age at inoculation did not influence virus titers in brain, spleen or intestine, but virus titers in liver were inversely proportional to age at inoculation. In 6-wk-old BALE mice, virus was cleared from spleen, intestine and liver by day 30 and from brain by day 60. In intestine, MHV was localized to lymphoid tissue, without fecal excretion. SJL mice of all ages developed remarkably milder disease with low mortality occurring only among mice inoculated at 1 wk of age. SJL mice inoculated at 1 wk had disseminated infection at day 3, but lesions and antigen were cleared from most organs by day 5. Mice inoculated at 3 and 6 wk of age had minimal or no involvement of peripheral organs, and mice inoculated at 12 wk of age had infections restricted to the nose. At day 5, MHV titers in brain, liver, spleen and intestine were significantly lower or undetectable in SJL mice of all ages compared to age-matched BALB mice. In 6-wk-old mice, MHV was cleared from all organs by day 10. Serum antibody titers to MHV were many-fold higher in BALB mice, compared to SJL mice, which mounted only a modest response.
Url:
DOI: 10.1016/0168-1702(87)90030-X
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ISTEX:FA0D87316C9517B89C290FCBD6213E60D30C6277Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: Mouse hepatitis virus (MHV)-JHM infection was studied in genetically susceptible (BALB/cByJ) and resistant (SJL/J) mice following intranasal inoculation at 1, 3, 6 or 12 wk of age. Markers of infection included histology, immunohistochemistry, virus quantification and virus serology. All BALE mice developed severe disseminated disease with high mortality due to encephalitis and hepatitis. Peak MHV titers appeared in brain, liver, spleen and intestine on days 3 or 5. Age at inoculation did not influence virus titers in brain, spleen or intestine, but virus titers in liver were inversely proportional to age at inoculation. In 6-wk-old BALE mice, virus was cleared from spleen, intestine and liver by day 30 and from brain by day 60. In intestine, MHV was localized to lymphoid tissue, without fecal excretion. SJL mice of all ages developed remarkably milder disease with low mortality occurring only among mice inoculated at 1 wk of age. SJL mice inoculated at 1 wk had disseminated infection at day 3, but lesions and antigen were cleared from most organs by day 5. Mice inoculated at 3 and 6 wk of age had minimal or no involvement of peripheral organs, and mice inoculated at 12 wk of age had infections restricted to the nose. At day 5, MHV titers in brain, liver, spleen and intestine were significantly lower or undetectable in SJL mice of all ages compared to age-matched BALB mice. In 6-wk-old mice, MHV was cleared from all organs by day 10. Serum antibody titers to MHV were many-fold higher in BALB mice, compared to SJL mice, which mounted only a modest response.</div>
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