Coronavirus infects and causes demyelination in primate central nervous system
Identifieur interne : 001B67 ( Main/Merge ); précédent : 001B66; suivant : 001B68Coronavirus infects and causes demyelination in primate central nervous system
Auteurs : Ronald S. Murray [États-Unis] ; Guang-Yun Cai [États-Unis] ; Kristen Hoel [États-Unis] ; J.-Y. Zhang [États-Unis] ; Kenneth F. Soike [États-Unis] ; Gary F. Cabirac [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1992.
English descriptors
- Teeft :
- Academic press, Agms, Antigen detection, Arachnoid meninges, Blood samples, Bovine coronavirus, Brain tissue, Cdna, Cdna probes, Cell line, Cells lane, Choroid plexus, Chronic phase, Clinical signs, Conjunctival inoculation, Coronavirus, Coronavirus infection, Coronaviruses, Days postinoculation, Demyelinating, Demyelination, Electron microscopy, Encephalomyelitis, Human coronavirus, Hybridization, Infection, Infectious virus, Inflammation, Inoculated, Inoculated intracerebrally, Inoculation, Mouse brain, Mouse hepatitis virus, Murine, Murine coronaviruses, Neurotropic coronavirus, Neutralizing, Nucleocapsid gene, Primate, Primate system, Primates, Primer, Random hexamers, Reaction conditions, Rodent system, Room temperature, Sclerosis, Severe encephalomyelitis, Species specificity, Staining magnification, Subhuman primate, Substrate solution, Tissue culture, Tissue sections, Viral, Viral antigen, Viral products, Virol, Virus, Virus entry, Virus replication, Virus strain, Weiner, Western blot analysis, White matter, White matter areas, White matter inflammation, White matter vacuolation.
Abstract
Abstract: Two species of primates, Owl and African green monkeys, were inoculated intracerebrally with either the neurotropic mouse hepatitis virus JHM or the putative multiple sclerosis brain coronavirus isolate SD. These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.
Url:
DOI: 10.1016/0042-6822(92)90757-G
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These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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