Incidence of Gastrointestinal Stromal Tumor: A Retrospective Study Based on Immunohistochemical and Mutational Analyses
Identifieur interne : 001728 ( Main/Merge ); précédent : 001727; suivant : 001729Incidence of Gastrointestinal Stromal Tumor: A Retrospective Study Based on Immunohistochemical and Mutational Analyses
Auteurs : Chi-Yuan Tzen [Taïwan] ; Jia-Hua Wang [Singapour] ; Ying-Jie Huang [Singapour] ; Man-Ning Wang [Taïwan] ; Pei-Chun Lin [Taïwan] ; Guan-Lin Lai [Taïwan] ; Chiao-Yun Wu [Taïwan] ; Chin-Yuan Tzen [Taïwan]Source :
- Digestive Diseases and Sciences [ 0163-2116 ] ; 2007-03-01.
English descriptors
- KwdEn :
Abstract
Abstract: The aim of this study is to estimate the incidence of the gastrointestinal stromal tumor after the previous diagnoses were confirmed and/or revised by both immunohistochemical and mutational analyses. We reviewed 17,858 surgically excised gastrointestinal lesions in our hospital from 1998 to 2004. All mesenchymal tumors were examined for CD117 expression by immunohistochemistry, and every CD117-negative mesenchymal tumors were further subjected to mutational analysis for KIT and PDGFRA exons. The results showed that approximately 35% of gastrointestinal stromal tumors were misdiagnosed if immunohistochemical analysis of CD117 expression was not performed; and approximately 15% misdiagnosed if mutation analysis was not available. Because approximately 4.72% of patients with gastrointestinal malignancies in Taiwan were treated in our hospital and the average of newly diagnosed gastrointestinal stromal tumors in our hospital was 14.33 cases per year, the estimated annual incidents of gastrointestinal stromal tumor in Taiwan were 303.60. Therefore, the annual incidence of gastrointestinal stromal tumor is 13.74 per million Taiwanese.
Url:
- https://api.istex.fr/ark:/67375/VQC-LD66J8SF-L/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087581
DOI: 10.1007/s10620-006-9480-y
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<author><name sortKey="Wu, Chiao Yun" sort="Wu, Chiao Yun" uniqKey="Wu C" first="Chiao-Yun" last="Wu">Chiao-Yun Wu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Medical Record,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tzen, Chin Yuan" sort="Tzen, Chin Yuan" uniqKey="Tzen C" first="Chin-Yuan" last="Tzen">Chin-Yuan Tzen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">45 Minsheng Road, Tamshui, Taipei, 251 Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>45 Minsheng Road, Tamshui, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Department of Pathology,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17253141</idno>
<idno type="pmc">7087581</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087581</idno>
<idno type="RBID">PMC:7087581</idno>
<idno type="doi">10.1007/s10620-006-9480-y</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000248</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000248</idno>
<idno type="wicri:Area/Pmc/Curation">000248</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">000951</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000951</idno>
<idno type="wicri:Area/Ncbi/Merge">000103</idno>
<idno type="wicri:Area/Ncbi/Curation">000103</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000103</idno>
<idno type="wicri:doubleKey">0163-2116:2007:Tzen C:incidence:of:gastrointestinal</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Incidence of Gastrointestinal Stromal Tumor: A Retrospective Study Based on Immunohistochemical and Mutational Analyses</title>
<author><name sortKey="Tzen, Chi Yuan" sort="Tzen, Chi Yuan" uniqKey="Tzen C" first="Chi-Yuan" last="Tzen">Chi-Yuan Tzen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Department of Pathology,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Jia Hua" sort="Wang, Jia Hua" uniqKey="Wang J" first="Jia-Hua" last="Wang">Jia-Hua Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.410761.5</institution-id>
<institution>Asia Pacific,</institution>
<institution>Novartis (Singapore) Pte. Ltd.,</institution>
</institution-wrap>
Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Ying Jie" sort="Huang, Ying Jie" uniqKey="Huang Y" first="Ying-Jie" last="Huang">Ying-Jie Huang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.410761.5</institution-id>
<institution>Asia Pacific,</institution>
<institution>Novartis (Singapore) Pte. Ltd.,</institution>
</institution-wrap>
Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Man Ning" sort="Wang, Man Ning" uniqKey="Wang M" first="Man-Ning" last="Wang">Man-Ning Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Department of Pathology,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lin, Pei Chun" sort="Lin, Pei Chun" uniqKey="Lin P" first="Pei-Chun" last="Lin">Pei-Chun Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Department of Medical Research,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lai, Guan Lin" sort="Lai, Guan Lin" uniqKey="Lai G" first="Guan-Lin" last="Lai">Guan-Lin Lai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Department of Medical Research,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wu, Chiao Yun" sort="Wu, Chiao Yun" uniqKey="Wu C" first="Chiao-Yun" last="Wu">Chiao-Yun Wu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Medical Record,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tzen, Chin Yuan" sort="Tzen, Chin Yuan" uniqKey="Tzen C" first="Chin-Yuan" last="Tzen">Chin-Yuan Tzen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">45 Minsheng Road, Tamshui, Taipei, 251 Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>45 Minsheng Road, Tamshui, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413593.9</institution-id>
<institution-id institution-id-type="ISNI">000000040573007X</institution-id>
<institution>Department of Pathology,</institution>
<institution>Mackay Memorial Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Digestive Diseases and Sciences</title>
<idno type="ISSN">0163-2116</idno>
<idno type="eISSN">1573-2568</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The aim of this study is to estimate the incidence of the gastrointestinal stromal tumor after the previous diagnoses were confirmed and/or revised by both immunohistochemical and mutational analyses. We reviewed 17,858 surgically excised gastrointestinal lesions in our hospital from 1998 to 2004. All mesenchymal tumors were examined for CD117 expression by immunohistochemistry, and every CD117-negative mesenchymal tumors were further subjected to mutational analysis for <italic>KIT</italic>
and <italic>PDGFRA</italic>
exons. The results showed that approximately 35% of gastrointestinal stromal tumors were misdiagnosed if immunohistochemical analysis of CD117 expression was not performed; and approximately 15% misdiagnosed if mutation analysis was not available. Because approximately 4.72% of patients with gastrointestinal malignancies in Taiwan were treated in our hospital and the average of newly diagnosed gastrointestinal stromal tumors in our hospital was 14.33 cases per year, the estimated annual incidents of gastrointestinal stromal tumor in Taiwan were 303.60. Therefore, the annual incidence of gastrointestinal stromal tumor is 13.74 per million Taiwanese.</p>
</div>
</front>
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</biblStruct>
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</analytic>
</biblStruct>
</listBibl>
</div1>
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