Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models.
Identifieur interne : 001649 ( Main/Merge ); précédent : 001648; suivant : 001650Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models.
Auteurs : Masaji Okada [Japon] ; Yoshinobu Okuno ; Satomi Hashimoto ; Yoko Kita ; Noriko Kanamaru ; Yasuko Nishida ; Yoshie Tsunai ; Ruriko Inoue ; Hitoshi Nakatani ; Reiko Fukamizu ; Yumi Namie ; Junko Yamada ; Kyoko Takao ; Ritsuko Asai ; Ryoko Asaki ; Tetsuo Kase ; Yuji Takemoto ; Shigeto Yoshida ; J S M. Peiris ; Pei-Jer Chen ; Naoki Yamamoto ; Tatsuji Nomura ; Isao Ishida ; Shigeru Morikawa ; Masato Tashiro ; Mitsunori SakataniSource :
- Vaccine [ 0264-410X ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Immunisation passive (), Immunothérapie, Lymphocytes T cytotoxiques (immunologie), Modèles animaux de maladie humaine, Souris, Souris SCID, Syndrome respiratoire aigu sévère (), Vaccins antiviraux (administration et posologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (génétique), Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (métabolisme).
- MESH :
- administration et posologie : Vaccins antiviraux, Vaccins à ADN.
- génétique : Vaccins à ADN, Virus du SRAS.
- immunologie : Lymphocytes T cytotoxiques, Virus du SRAS.
- métabolisme : Virus du SRAS.
- Animaux, Immunisation passive, Immunothérapie, Modèles animaux de maladie humaine, Souris, Souris SCID, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Immunization, Passive (methods), Immunotherapy, Mice, Mice, SCID, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (prevention & control), T-Lymphocytes, Cytotoxic (immunology), Vaccines, DNA (administration & dosage), Vaccines, DNA (genetics), Viral Vaccines (administration & dosage).
- MESH :
- chemical , administration & dosage : Vaccines, DNA, Viral Vaccines.
- genetics : SARS Virus, Vaccines, DNA.
- immunology : SARS Virus, T-Lymphocytes, Cytotoxic.
- metabolism : SARS Virus.
- methods : Immunization, Passive.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Immunotherapy, Mice, Mice, SCID.
Abstract
We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor gamma-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.
DOI: 10.1016/j.vaccine.2007.01.032
PubMed: 17289225
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pubmed:17289225Le document en format XML
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type="wicri:Area/Main/Merge">001649</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models.</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku, Sakai, Osaka 591-8555, Japan. okm@kch.hosp.go.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku, Sakai, Osaka 591-8555</wicri:regionArea><wicri:noRegion>Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name></author><author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name></author><author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name></author><author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name></author><author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name></author><author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name></author><author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name></author><author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name></author><author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name></author><author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Immunization, Passive (methods)</term><term>Immunotherapy</term><term>Mice</term><term>Mice, SCID</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Vaccines, DNA (administration & dosage)</term><term>Vaccines, DNA (genetics)</term><term>Viral Vaccines (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Immunisation passive ()</term><term>Immunothérapie</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris SCID</term><term>Syndrome respiratoire aigu sévère ()</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins à ADN (administration et posologie)</term><term>Vaccins à ADN (génétique)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, DNA</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term><term>Vaccines, DNA</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vaccins à ADN</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T cytotoxiques</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Immunotherapy</term><term>Mice</term><term>Mice, SCID</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immunisation passive</term><term>Immunothérapie</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris SCID</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor gamma-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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