Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Identifieur interne : 001042 ( Main/Merge ); précédent : 001041; suivant : 001043Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Auteurs : Y. M. Arabi ; A. Harthi [Arabie saoudite] ; J. Hussein [Arabie saoudite] ; A. Bouchama [Arabie saoudite] ; S. Johani [Arabie saoudite] ; A. H. Hajeer [Arabie saoudite] ; B. T. Saeed [Arabie saoudite] ; A. Wahbi [Arabie saoudite] ; A. Saedy [Arabie saoudite] ; T. Aldabbagh [Arabie saoudite] ; R. Okaili [Arabie saoudite] ; M. Sadat [Arabie saoudite] ; H. Balkhy [Arabie saoudite]Source :
- Infection [ 0300-8126 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Humains, Imagerie par résonance magnétique, Infections à coronavirus (anatomopathologie), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Maladies du système nerveux (anatomopathologie), Maladies du système nerveux (diagnostic), Maladies du système nerveux (virologie), Mâle, Sujet âgé.
- MESH :
- anatomopathologie : Infections à coronavirus, Maladies du système nerveux.
- diagnostic : Infections à coronavirus, Maladies du système nerveux.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus, Maladies du système nerveux.
- Adulte d'âge moyen, Arabie saoudite, Humains, Imagerie par résonance magnétique, Mâle, Sujet âgé.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Aged, Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Coronavirus Infections (virology), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nervous System Diseases (diagnosis), Nervous System Diseases (pathology), Nervous System Diseases (virology), Saudi Arabia.
- MESH :
- geographic : Saudi Arabia.
- diagnosis : Coronavirus Infections, Nervous System Diseases.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections, Nervous System Diseases.
- virology : Coronavirus Infections, Nervous System Diseases.
- Aged, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.
Data was retrospectively collected from three patients admitted with MERS-CoV infection to Intensive Care unit (ICU) at King Abdulaziz Medical City, Riyadh. They were managed separately in three different wards prior to their admission to ICU.
The three patients presented with severe neurologic syndrome which included altered level of consciousness ranging from confusion to coma, ataxia, and focal motor deficit. Brain MRI revealed striking changes characterized by widespread, bilateral hyperintense lesions on T2-weighted imaging within the white matter and subcortical areas of the frontal, temporal, and parietal lobes, the basal ganglia, and corpus callosum. None of the lesions showed gadolinium enhancement.
CNS involvement should be considered in patients with MERS-CoV and progressive neurological disease, and further elucidation of the pathophysiology of this virus is needed.
The online version of this article (doi:10.1007/s15010-015-0720-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s15010-015-0720-y
PubMed: 25600929
PubMed Central: 4521086
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PMC:4521086Le document en format XML
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.</p>
</sec>
<sec><title>Methods</title>
<p>Data was retrospectively collected from three patients admitted with MERS-CoV infection to Intensive Care unit (ICU) at King Abdulaziz Medical City, Riyadh. They were managed separately in three different wards prior to their admission to ICU.</p>
</sec>
<sec><title>Finding</title>
<p>The three patients presented with severe neurologic syndrome which included altered level of consciousness ranging from confusion to coma, ataxia, and focal motor deficit. Brain MRI revealed striking changes characterized by widespread, bilateral hyperintense lesions on T2-weighted imaging within the white matter and subcortical areas of the frontal, temporal, and parietal lobes, the basal ganglia, and corpus callosum. None of the lesions showed gadolinium enhancement.</p>
</sec>
<sec><title>Interpretation</title>
<p>CNS involvement should be considered in patients with MERS-CoV and progressive neurological disease, and further elucidation of the pathophysiology of this virus is needed.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1007/s15010-015-0720-y) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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