Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: a case–control study protocol
Identifieur interne : 000D98 ( Main/Merge ); précédent : 000D97; suivant : 000D99Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: a case–control study protocol
Auteurs : Mejbah Uddin Bhuiyan [Australie] ; Thomas L. Snelling [Australie] ; Rachel West [Australie] ; Jurissa Lang [Australie] ; Tasmina Rahman [Australie] ; Meredith L. Borland [Australie] ; Ruth Thornton [Australie] ; Lea-Ann Kirkham [Australie] ; Chisha Sikazwe [Australie] ; Andrew C. Martin [Australie] ; Peter C. Richmond [Australie] ; David W. Smith [Australie] ; Adam Jaffe [Australie] ; Christopher C. Blyth [Australie]Source :
- BMJ Open [ 2044-6055 ] ; 2018.
Abstract
Pneumonia is the leading cause of childhood morbidity and mortality globally. Introduction of the conjugate
We are conducting a prospective case–control study (PneumoWA) where cases are children with radiologically confirmed pneumonia admitted to Princess Margaret Hospital for Children (PMH) and controls are healthy children identified from PMH outpatient clinics and from local community immunisation clinics. The case–control ratio is 1:1 with 250 children to be recruited in each arm. Nasopharyngeal swabs are collected from both cases and controls to detect the presence of viruses and bacteria by PCR; pathogen load will be assessed by quantitative PCR. The prevalence of pathogens detected in cases and controls will be compared, the OR of detection and population attributable fraction to CAP for each pathogen will be determined; relationships between pathogen load and disease status and severity will be explored.
This study has been approved by the human research ethics committees of PMH, Perth, Australia (PMH HREC REF 2014117EP). Findings will be disseminated at research conferences and in peer-reviewed journals.
Url:
DOI: 10.1136/bmjopen-2017-020646
PubMed: 29549211
PubMed Central: 5857668
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PMC:5857668Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: a case–control study protocol</title>
<author><name sortKey="Bhuiyan, Mejbah Uddin" sort="Bhuiyan, Mejbah Uddin" uniqKey="Bhuiyan M" first="Mejbah Uddin" last="Bhuiyan">Mejbah Uddin Bhuiyan</name>
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<author><name sortKey="Snelling, Thomas L" sort="Snelling, Thomas L" uniqKey="Snelling T" first="Thomas L" last="Snelling">Thomas L. Snelling</name>
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<author><name sortKey="West, Rachel" sort="West, Rachel" uniqKey="West R" first="Rachel" last="West">Rachel West</name>
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<author><name sortKey="Lang, Jurissa" sort="Lang, Jurissa" uniqKey="Lang J" first="Jurissa" last="Lang">Jurissa Lang</name>
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<author><name sortKey="Rahman, Tasmina" sort="Rahman, Tasmina" uniqKey="Rahman T" first="Tasmina" last="Rahman">Tasmina Rahman</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Borland, Meredith L" sort="Borland, Meredith L" uniqKey="Borland M" first="Meredith L" last="Borland">Meredith L. Borland</name>
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<author><name sortKey="Thornton, Ruth" sort="Thornton, Ruth" uniqKey="Thornton R" first="Ruth" last="Thornton">Ruth Thornton</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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</nlm:aff>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Kirkham, Lea Ann" sort="Kirkham, Lea Ann" uniqKey="Kirkham L" first="Lea-Ann" last="Kirkham">Lea-Ann Kirkham</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="department">Faculty of Health and Medical Sciences</institution>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Sikazwe, Chisha" sort="Sikazwe, Chisha" uniqKey="Sikazwe C" first="Chisha" last="Sikazwe">Chisha Sikazwe</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Martin, Andrew C" sort="Martin, Andrew C" uniqKey="Martin A" first="Andrew C" last="Martin">Andrew C. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Infectious Diseases</institution>
,<institution>Princess Margaret Hospital for Children</institution>
,<addr-line content-type="city">Perth</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Richmond, Peter C" sort="Richmond, Peter C" uniqKey="Richmond P" first="Peter C" last="Richmond">Peter C. Richmond</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Division of Paediatrics, Faculty of Health and Medical Sciences</institution>
,<institution>School of Medicine, The University of Western Australia</institution>
,<addr-line content-type="city">Perth</addr-line>
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,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Infectious Diseases</institution>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Smith, David W" sort="Smith, David W" uniqKey="Smith D" first="David W" last="Smith">David W. Smith</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jaffe, Adam" sort="Jaffe, Adam" uniqKey="Jaffe A" first="Adam" last="Jaffe">Adam Jaffe</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="department">Faculty of Medicine</institution>
,<institution>School of Women’s and Children’s Health, University of New South Wales</institution>
,<addr-line content-type="city">Sydney</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blyth, Christopher C" sort="Blyth, Christopher C" uniqKey="Blyth C" first="Christopher C" last="Blyth">Christopher C. Blyth</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Division of Paediatrics, Faculty of Health and Medical Sciences</institution>
,<institution>School of Medicine, The University of Western Australia</institution>
,<addr-line content-type="city">Perth</addr-line>
,<addr-line content-type="state">Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute</institution>
,<addr-line content-type="city">Perth</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Infectious Diseases</institution>
,<institution>Princess Margaret Hospital for Children</institution>
,<addr-line content-type="city">Perth</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>PathWest Laboratory Medicine WA</institution>
,<addr-line content-type="city">Perth</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">BMJ Open</title>
<idno type="eISSN">2044-6055</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Pneumonia is the leading cause of childhood morbidity and mortality globally. Introduction of the conjugate <italic>Haemophilus influenzae</italic>
B and multivalent pneumococcal vaccines in developed countries including Australia has significantly reduced the overall burden of bacterial pneumonia. With the availability of molecular diagnostics, viruses are frequently detected in children with pneumonia either as primary pathogens or predispose to secondary bacterial infection. Many respiratory pathogens that are known to cause pneumonia are also identified in asymptomatic children, so the true contribution of these pathogens to childhood community-acquired pneumonia (CAP) remains unclear. Since the introduction of pneumococcal vaccines, very few comprehensive studies from developed countries have attempted to determine the bacterial and viral aetiology of pneumonia. We aim to determine the contribution of bacteria and viruses to childhood CAP to inform further development of effective diagnosis, treatment and preventive strategies.</p>
</sec>
<sec><title>Methods and analysis</title>
<p>We are conducting a prospective case–control study (PneumoWA) where cases are children with radiologically confirmed pneumonia admitted to Princess Margaret Hospital for Children (PMH) and controls are healthy children identified from PMH outpatient clinics and from local community immunisation clinics. The case–control ratio is 1:1 with 250 children to be recruited in each arm. Nasopharyngeal swabs are collected from both cases and controls to detect the presence of viruses and bacteria by PCR; pathogen load will be assessed by quantitative PCR. The prevalence of pathogens detected in cases and controls will be compared, the OR of detection and population attributable fraction to CAP for each pathogen will be determined; relationships between pathogen load and disease status and severity will be explored.</p>
</sec>
<sec><title>Ethics and dissemination</title>
<p>This study has been approved by the human research ethics committees of PMH, Perth, Australia (PMH HREC REF 2014117EP). Findings will be disseminated at research conferences and in peer-reviewed journals.</p>
</sec>
</div>
</front>
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