The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer
Identifieur interne : 000D12 ( Main/Exploration ); précédent : 000D11; suivant : 000D13The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer
Auteurs : Hung-Chi Yang [Taïwan] ; Yi-Hsuan Wu ; Wei-Chen Yen ; Hui-Ya Liu ; Tsong-Long Hwang [Taïwan] ; Arnold Stern ; Daniel Tsun-Yee Chiu [Taïwan]Source :
- Cells [ 2073-4409 ] ; 2019.
Abstract
The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal growth. Altered G6PD activity is associated with pathophysiology, such as autophagy, insulin resistance, infection, inflammation, as well as diabetes and hypertension. Aberrant activation of G6PD leads to enhanced cell proliferation and adaptation in many types of cancers. The present review aims to update the existing knowledge concerning G6PD and emphasizes how G6PD modulates redox signaling and affects cell survival and demise, particularly in diseases such as cancer. Exploiting G6PD as a potential drug target against cancer is also discussed.
Url:
DOI: 10.3390/cells8091055
PubMed: 31500396
PubMed Central: 6770671
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal growth. Altered G6PD activity is associated with pathophysiology, such as autophagy, insulin resistance, infection, inflammation, as well as diabetes and hypertension. Aberrant activation of G6PD leads to enhanced cell proliferation and adaptation in many types of cancers. The present review aims to update the existing knowledge concerning G6PD and emphasizes how G6PD modulates redox signaling and affects cell survival and demise, particularly in diseases such as cancer. Exploiting G6PD as a potential drug target against cancer is also discussed.</p>
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<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><noCountry><name sortKey="Liu, Hui Ya" sort="Liu, Hui Ya" uniqKey="Liu H" first="Hui-Ya" last="Liu">Hui-Ya Liu</name>
<name sortKey="Stern, Arnold" sort="Stern, Arnold" uniqKey="Stern A" first="Arnold" last="Stern">Arnold Stern</name>
<name sortKey="Wu, Yi Hsuan" sort="Wu, Yi Hsuan" uniqKey="Wu Y" first="Yi-Hsuan" last="Wu">Yi-Hsuan Wu</name>
<name sortKey="Yen, Wei Chen" sort="Yen, Wei Chen" uniqKey="Yen W" first="Wei-Chen" last="Yen">Wei-Chen Yen</name>
</noCountry>
<country name="Taïwan"><noRegion><name sortKey="Yang, Hung Chi" sort="Yang, Hung Chi" uniqKey="Yang H" first="Hung-Chi" last="Yang">Hung-Chi Yang</name>
</noRegion>
<name sortKey="Chiu, Daniel Tsun Yee" sort="Chiu, Daniel Tsun Yee" uniqKey="Chiu D" first="Daniel Tsun-Yee" last="Chiu">Daniel Tsun-Yee Chiu</name>
<name sortKey="Chiu, Daniel Tsun Yee" sort="Chiu, Daniel Tsun Yee" uniqKey="Chiu D" first="Daniel Tsun-Yee" last="Chiu">Daniel Tsun-Yee Chiu</name>
<name sortKey="Chiu, Daniel Tsun Yee" sort="Chiu, Daniel Tsun Yee" uniqKey="Chiu D" first="Daniel Tsun-Yee" last="Chiu">Daniel Tsun-Yee Chiu</name>
<name sortKey="Hwang, Tsong Long" sort="Hwang, Tsong Long" uniqKey="Hwang T" first="Tsong-Long" last="Hwang">Tsong-Long Hwang</name>
<name sortKey="Hwang, Tsong Long" sort="Hwang, Tsong Long" uniqKey="Hwang T" first="Tsong-Long" last="Hwang">Tsong-Long Hwang</name>
<name sortKey="Hwang, Tsong Long" sort="Hwang, Tsong Long" uniqKey="Hwang T" first="Tsong-Long" last="Hwang">Tsong-Long Hwang</name>
<name sortKey="Hwang, Tsong Long" sort="Hwang, Tsong Long" uniqKey="Hwang T" first="Tsong-Long" last="Hwang">Tsong-Long Hwang</name>
<name sortKey="Hwang, Tsong Long" sort="Hwang, Tsong Long" uniqKey="Hwang T" first="Tsong-Long" last="Hwang">Tsong-Long Hwang</name>
</country>
</tree>
</affiliations>
</record>
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