Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication
Identifieur interne : 001370 ( Main/Exploration ); précédent : 001369; suivant : 001371Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication
Auteurs : Chih-Chun Wen [Taïwan] ; Lie-Fen Shyur [Taïwan] ; Jia-Tsrong Jan [Taïwan] ; Po-Huang Liang [Taïwan] ; Chih-Jung Kuo [Taïwan, États-Unis] ; Palanisamy Arulselvan [Taïwan] ; Jin-Bin Wu [Taïwan] ; Sheng-Chu Kuo [Taïwan] ; Ning-Sun Yang [Taïwan]Source :
- Journal of Traditional and Complementary Medicine [ 2225-4110 ] ; 2011.
Abstract
Development of anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) agents is pivotal to prevent the reemergence of the life-threatening disease, SARS. In this study, more than 200 extracts from Chinese medicinal herbs were evaluated for anti-SARS-CoV activities using a cell-based assay that measured SARS-CoV-induced cytopathogenic effect (CPE)
severe acute respiratory syndrome
coronavirus
cytopathogenic effect
traditional Chinese medicine
Url:
PubMed: 24716104
PubMed Central: 3942999
Affiliations:
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, <italic>Dioscorea batatas</italic>
, <italic>Cassia tora</italic>
, and <italic>Taxillus chinensis</italic>
inhibit SARS-CoV replication</title>
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, <italic>Gentiana scabra</italic>
, <italic>Dioscorea batatas</italic>
, <italic>Cassia tora</italic>
, and <italic>Taxillus chinensis</italic>
inhibit SARS-CoV replication</title>
<author><name sortKey="Wen, Chih Chun" sort="Wen, Chih Chun" uniqKey="Wen C" first="Chih-Chun" last="Wen">Chih-Chun Wen</name>
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<author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name>
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<series><title level="j">Journal of Traditional and Complementary Medicine</title>
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<front><div type="abstract" xml:lang="en"><p>Development of anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) agents is pivotal to prevent the reemergence of the life-threatening disease, SARS. In this study, more than 200 extracts from Chinese medicinal herbs were evaluated for anti-SARS-CoV activities using a cell-based assay that measured SARS-CoV-induced cytopathogenic effect (CPE) <italic>in vitro</italic>
on Vero E6 cells. Six herbal extracts, one each from Gentianae Radix (龍膽 lóng dǎn; the dried rhizome of <italic>Gentiana scabra</italic>
), Dioscoreae Rhizoma (山藥 shān yào; the tuber of <italic>Dioscorea batatas</italic>
), Cassiae Semen (決明子 jué míng zǐ; the dried seed of <italic>Cassia tora</italic>
) and Loranthi Ramus (桑寄生 sāng jì shēng; the dried stem, with leaf of <italic>Taxillus chinensis</italic>
) (designated as GSH, DBM, CTH and TCH, respectively), and two from Rhizoma Cibotii (狗脊 gǒu jǐ; the dried rhizome of <italic>Cibotium barometz</italic>
) (designated as CBE and CBM), were found to be potent inhibitors of SARS-CoV at concentrations between 25 and 200 μg/ml. The concentrations of the six extracts needed to inhibit 50% of Vero E6 cell proliferation (CC<sub>50</sub>
) and 50% of viral replication (EC<sub>50</sub>
) were determined. The resulting selective index values (SI = CC<sub>50</sub>
/EC<sub>50</sub>
) of the most effective extracts CBE, GSH, DBM, CTH and TCH were > 59.4, > 57.5, > 62.1, > 59.4, and > 92.9, respectively. Among these extracts, CBM and DBM also showed significant inhibition of SARS-CoV 3CL protease activity with IC<sub>50</sub>
values of 39 μg/ml and 44 μg/ml, respectively. Our findings suggest that these six herbal extracts may have potential as candidates for future development of anti-SARS therapeutics.</p>
<sec id="st1"><title></title>
<def-list><title>Abbreviations</title>
<def-item><term>SARS,</term>
<def><p>severe acute respiratory syndrome</p>
</def>
</def-item>
<def-item><term>CoV,</term>
<def><p>coronavirus</p>
</def>
</def-item>
<def-item><term>CPE,</term>
<def><p>cytopathogenic effect</p>
</def>
</def-item>
<def-item><term>TCM,</term>
<def><p>traditional Chinese medicine</p>
</def>
</def-item>
</def-list>
</sec>
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</TEI>
<affiliations><list><country><li>Taïwan</li>
<li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
<settlement><li>Ithaca (New York)</li>
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<orgName><li>Université Cornell</li>
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</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Wen, Chih Chun" sort="Wen, Chih Chun" uniqKey="Wen C" first="Chih-Chun" last="Wen">Chih-Chun Wen</name>
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<name sortKey="Arulselvan, Palanisamy" sort="Arulselvan, Palanisamy" uniqKey="Arulselvan P" first="Palanisamy" last="Arulselvan">Palanisamy Arulselvan</name>
<name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name>
<name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name>
<name sortKey="Kuo, Sheng Chu" sort="Kuo, Sheng Chu" uniqKey="Kuo S" first="Sheng-Chu" last="Kuo">Sheng-Chu Kuo</name>
<name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name>
<name sortKey="Shyur, Lie Fen" sort="Shyur, Lie Fen" uniqKey="Shyur L" first="Lie-Fen" last="Shyur">Lie-Fen Shyur</name>
<name sortKey="Wen, Chih Chun" sort="Wen, Chih Chun" uniqKey="Wen C" first="Chih-Chun" last="Wen">Chih-Chun Wen</name>
<name sortKey="Wu, Jin Bin" sort="Wu, Jin Bin" uniqKey="Wu J" first="Jin-Bin" last="Wu">Jin-Bin Wu</name>
<name sortKey="Yang, Ning Sun" sort="Yang, Ning Sun" uniqKey="Yang N" first="Ning-Sun" last="Yang">Ning-Sun Yang</name>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name>
</region>
</country>
</tree>
</affiliations>
</record>
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