Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances
Identifieur interne : 001383 ( Main/Exploration ); précédent : 001382; suivant : 001384Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances
Auteurs : Sarvesh K. Paliwal [Inde] ; Ankita Narayan Verma [Inde] ; Shailendra Paliwal [Inde]Source :
- Scientia Pharmaceutica [ 0036-8709 ] ; 2011.
Abstract
Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate
Url:
DOI: 10.3797/scipharm.1012-08
PubMed: 21886894
PubMed Central: 3163371
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances</title>
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<front><div type="abstract" xml:lang="en"><p>Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate <italic>Trypanosoma brucei</italic>
that mostly occurs in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on only six drugs, five of which have been developed more than 30 years ago, have undesirable toxic side effects and most of them show drug-resistance. Though development of new anti-trypanosomal drugs seems to be a priority area research in this area has lagged far behind. The given review mainly focus upon the recent synthetic and computer based approaches made by various research groups for the development of newer anti-trypanosomal analogues which may have improved efficacy and oral bioavailability than the present ones. The given paper also attempts to investigate the relationship between the various physiochemical parameters and anti-trypanosomal activity that may be helpful in development of potent anti-trypanosomal agents against sleeping sickness.</p>
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<tree><country name="Inde"><noRegion><name sortKey="Paliwal, Sarvesh K" sort="Paliwal, Sarvesh K" uniqKey="Paliwal S" first="Sarvesh K." last="Paliwal">Sarvesh K. Paliwal</name>
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