Variable responses of formyl peptide receptor haplotypes toward bacterial peptides
Identifieur interne : 001603 ( Main/Exploration ); précédent : 001602; suivant : 001604Variable responses of formyl peptide receptor haplotypes toward bacterial peptides
Auteurs : Jeannie M. Gripentrog [États-Unis] ; John S. Mills [États-Unis] ; George J. Saari [États-Unis] ; Heini M. Miettinen [États-Unis]Source :
- Immunogenetics [ 0093-7711 ] ; 2008-02-01.
English descriptors
Abstract
Abstract: The chemoattractant neutrophil formyl peptide receptor (FPR) binds bacterial and mitochondrial N-formylated peptides, which allows the neutrophils to find the bacterial source and/or site of tissue damage. Certain inflammatory disorders may be due in part to an impaired innate immune system that does not respond to acute bacterial damage in a timely fashion. Because the human FPR is encoded by a large number of different haplotypes arising from ten single-nucleotide polymorphisms, we examined the possibility that some of these haplotypes are functionally distinct. We analyzed the response of three common FPR haplotypes to peptides from Escherichia coli, Mycobacterium avium ssp. paratuberculosis, and human mitochondria. All three haplotypes responded similarly to the E. coli and mitochondrial peptides, whereas one required a higher concentration of the M. avium peptide fMFEDAVAWF for receptor downregulation, receptor signaling, and chemotaxis. This raises the possibility of additional bacterial species differences in functional responses among FPR variants and establishes a precedent with potentially important implications for our innate immune response against bacterial infections. We also investigated whether certain FPR haplotypes are associated with rheumatoid arthritis (RA) by sequencing FPR1 from 148 Caucasian individuals. The results suggested that FPR haplotypes do not significantly contribute toward RA.
Url:
- https://api.istex.fr/ark:/67375/VQC-83BDG860-N/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435592
DOI: 10.1007/s00251-008-0277-3
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000723
- to stream Istex, to step Curation: 000690
- to stream Istex, to step Checkpoint: 000153
- to stream Pmc, to step Corpus: 000265
- to stream Pmc, to step Curation: 000265
- to stream Pmc, to step Checkpoint: 000906
- to stream Ncbi, to step Merge: 000132
- to stream Ncbi, to step Curation: 000132
- to stream Ncbi, to step Checkpoint: 000132
- to stream Main, to step Merge: 001607
- to stream Main, to step Curation: 001603
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Variable responses of formyl peptide receptor haplotypes toward bacterial peptides</title>
<author><name sortKey="Gripentrog, Jeannie M" sort="Gripentrog, Jeannie M" uniqKey="Gripentrog J" first="Jeannie M." last="Gripentrog">Jeannie M. Gripentrog</name>
</author>
<author><name sortKey="Mills, John S" sort="Mills, John S" uniqKey="Mills J" first="John S." last="Mills">John S. Mills</name>
</author>
<author><name sortKey="Saari, George J" sort="Saari, George J" uniqKey="Saari G" first="George J." last="Saari">George J. Saari</name>
</author>
<author><name sortKey="Miettinen, Heini M" sort="Miettinen, Heini M" uniqKey="Miettinen H" first="Heini M." last="Miettinen">Heini M. Miettinen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:25810C168D96B2F9E3F9C24944A54841D96FD9A8</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1007/s00251-008-0277-3</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-83BDG860-N/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000723</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000723</idno>
<idno type="wicri:Area/Istex/Curation">000690</idno>
<idno type="wicri:Area/Istex/Checkpoint">000153</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000153</idno>
<idno type="wicri:doubleKey">0093-7711:2008:Gripentrog J:variable:responses:of</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435592</idno>
<idno type="RBID">PMC:2435592</idno>
<idno type="wicri:Area/Pmc/Corpus">000265</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000265</idno>
<idno type="wicri:Area/Pmc/Curation">000265</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000265</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000906</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000906</idno>
<idno type="wicri:Area/Ncbi/Merge">000132</idno>
<idno type="wicri:Area/Ncbi/Curation">000132</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000132</idno>
<idno type="wicri:doubleKey">0093-7711:2008:Gripentrog J:variable:responses:of</idno>
<idno type="wicri:Area/Main/Merge">001607</idno>
<idno type="wicri:Area/Main/Curation">001603</idno>
<idno type="wicri:Area/Main/Exploration">001603</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Variable responses of formyl peptide receptor haplotypes toward bacterial peptides</title>
<author><name sortKey="Gripentrog, Jeannie M" sort="Gripentrog, Jeannie M" uniqKey="Gripentrog J" first="Jeannie M." last="Gripentrog">Jeannie M. Gripentrog</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Montana State University, 109 Lewis Hall, 59717, Bozeman, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mills, John S" sort="Mills, John S" uniqKey="Mills J" first="John S." last="Mills">John S. Mills</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Montana State University, 109 Lewis Hall, 59717, Bozeman, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saari, George J" sort="Saari, George J" uniqKey="Saari G" first="George J." last="Saari">George J. Saari</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Bozeman Deaconess Health Group and WWAMI Medical Education Program, Montana State University, 59717, Bozeman, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miettinen, Heini M" sort="Miettinen, Heini M" uniqKey="Miettinen H" first="Heini M." last="Miettinen">Heini M. Miettinen</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Montana State University, 109 Lewis Hall, 59717, Bozeman, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Immunogenetics</title>
<title level="j" type="abbrev">Immunogenetics</title>
<idno type="ISSN">0093-7711</idno>
<idno type="eISSN">1432-1211</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="2008-02-01">2008-02-01</date>
<biblScope unit="volume">60</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="83">83</biblScope>
<biblScope unit="page" to="93">93</biblScope>
</imprint>
<idno type="ISSN">0093-7711</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0093-7711</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell signaling</term>
<term>Chemoattractant receptor</term>
<term>Chemotaxis</term>
<term>Haplotype</term>
<term>Inflammation</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The chemoattractant neutrophil formyl peptide receptor (FPR) binds bacterial and mitochondrial N-formylated peptides, which allows the neutrophils to find the bacterial source and/or site of tissue damage. Certain inflammatory disorders may be due in part to an impaired innate immune system that does not respond to acute bacterial damage in a timely fashion. Because the human FPR is encoded by a large number of different haplotypes arising from ten single-nucleotide polymorphisms, we examined the possibility that some of these haplotypes are functionally distinct. We analyzed the response of three common FPR haplotypes to peptides from Escherichia coli, Mycobacterium avium ssp. paratuberculosis, and human mitochondria. All three haplotypes responded similarly to the E. coli and mitochondrial peptides, whereas one required a higher concentration of the M. avium peptide fMFEDAVAWF for receptor downregulation, receptor signaling, and chemotaxis. This raises the possibility of additional bacterial species differences in functional responses among FPR variants and establishes a precedent with potentially important implications for our innate immune response against bacterial infections. We also investigated whether certain FPR haplotypes are associated with rheumatoid arthritis (RA) by sequencing FPR1 from 148 Caucasian individuals. The results suggested that FPR haplotypes do not significantly contribute toward RA.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Montana</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Montana"><name sortKey="Gripentrog, Jeannie M" sort="Gripentrog, Jeannie M" uniqKey="Gripentrog J" first="Jeannie M." last="Gripentrog">Jeannie M. Gripentrog</name>
</region>
<name sortKey="Miettinen, Heini M" sort="Miettinen, Heini M" uniqKey="Miettinen H" first="Heini M." last="Miettinen">Heini M. Miettinen</name>
<name sortKey="Miettinen, Heini M" sort="Miettinen, Heini M" uniqKey="Miettinen H" first="Heini M." last="Miettinen">Heini M. Miettinen</name>
<name sortKey="Mills, John S" sort="Mills, John S" uniqKey="Mills J" first="John S." last="Mills">John S. Mills</name>
<name sortKey="Saari, George J" sort="Saari, George J" uniqKey="Saari G" first="George J." last="Saari">George J. Saari</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001603 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001603 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:25810C168D96B2F9E3F9C24944A54841D96FD9A8 |texte= Variable responses of formyl peptide receptor haplotypes toward bacterial peptides }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |