Expression of immunoreactive major histocompatibility complex products in human skeletal muscles
Identifieur interne : 001C92 ( Main/Exploration ); précédent : 001C91; suivant : 001C93Expression of immunoreactive major histocompatibility complex products in human skeletal muscles
Auteurs : George Karpati [Canada] ; Yannick Pouliot [Canada] ; Stirling Carpenter [Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 1988-01.
English descriptors
- Teeft :
- Blood vessels, Cryostat sections, Cytotoxic, Cytotoxic lymphocytes, Dermatomyositis, Duchenne, Duchenne dystrophy, Dystrophy, Histocompatibility, Immunoreactive, Immunoreactive class, Inclusion body myositis, Inflammatory, Inflammatory cells, Inflammatory myopathies, Interferon, Karpati, Lymphocyte, Major histocompatibility, Mhcp, Mhcp expression, Mhcp reactivity, Monoclonal, Monoclonal antibodies, Monoclonal antibody analysis, Mononuclear, Mononuclear cells, Muscle fibers, Myopathy, Myositis, Myotonic dystrophy, Partial invasion, Polymyositis, Serial sections, Skeletal muscle fibers, Strong expression, Strong reactivity, Surface membrane, Transplantation.
Abstract
Immunoreactive class 1 and class 2 major histocompatibility complex gene products (MHCP) and β2 microglobulin (β2MG) were demonstrated by microscopic immunocytochemistry in cryostat sections of skeletal muscle biopsies of 67 patients with various neuromuscular diseases. Diagnoses included normal muscle, chronic partial denervation, Duchenne dystrophy, polymyositis, dermatomyositis, inclusion body myositis, and miscellaneous neuromuscular diseases. Normal mature muscle fibers did not express MHCP, but blood vessels showed both class 1 and 2 MHCP and β2MG. Regenerating muscle fibers showed consistent sarcolemmal class 1 MHCP expression irrespective of the disease. In polymyositis, the majority of extrafusal muscle fibers of most patients showed strong sarcolemmal class 1 MHCP expression. In dermatomyositis, muscle fibers situated either in perifascicular or in randomly clustered distribution revealed strong class 1 MHCP reactivity. In inclusion body myositis, scattered small clusters of muscle fibers were positive for class 1 MHCP. In polymyositis and inclusion body myositis, particularly strong class 1 MHCP expression was invariably seen in nonnecrotic muscle fibers partially invaded by lymphocytes whose cytotoxic effects are believed to be class 1 MHCP restricted. Factors or agents that trigger class 1 MHCP expression are presumed also to sensitize lymphocytes to muscle fibers in these diseases, but their identity remains obscure at this time. In dermatomyositis, the expression of MHCP in perifascicular muscle fibers and in areas of capillary loss may represent the triggering of MHCP expression by a nonspecific cellular stress reaction, in this case probably low‐grade ischemia.
Url:
DOI: 10.1002/ana.410230111
Affiliations:
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type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Blood vessels</term><term>Cryostat sections</term><term>Cytotoxic</term><term>Cytotoxic lymphocytes</term><term>Dermatomyositis</term><term>Duchenne</term><term>Duchenne dystrophy</term><term>Dystrophy</term><term>Histocompatibility</term><term>Immunoreactive</term><term>Immunoreactive class</term><term>Inclusion body myositis</term><term>Inflammatory</term><term>Inflammatory cells</term><term>Inflammatory myopathies</term><term>Interferon</term><term>Karpati</term><term>Lymphocyte</term><term>Major histocompatibility</term><term>Mhcp</term><term>Mhcp expression</term><term>Mhcp reactivity</term><term>Monoclonal</term><term>Monoclonal antibodies</term><term>Monoclonal antibody analysis</term><term>Mononuclear</term><term>Mononuclear cells</term><term>Muscle fibers</term><term>Myopathy</term><term>Myositis</term><term>Myotonic dystrophy</term><term>Partial invasion</term><term>Polymyositis</term><term>Serial sections</term><term>Skeletal muscle fibers</term><term>Strong expression</term><term>Strong reactivity</term><term>Surface membrane</term><term>Transplantation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Immunoreactive class 1 and class 2 major histocompatibility complex gene products (MHCP) and β2 microglobulin (β2MG) were demonstrated by microscopic immunocytochemistry in cryostat sections of skeletal muscle biopsies of 67 patients with various neuromuscular diseases. Diagnoses included normal muscle, chronic partial denervation, Duchenne dystrophy, polymyositis, dermatomyositis, inclusion body myositis, and miscellaneous neuromuscular diseases. Normal mature muscle fibers did not express MHCP, but blood vessels showed both class 1 and 2 MHCP and β2MG. Regenerating muscle fibers showed consistent sarcolemmal class 1 MHCP expression irrespective of the disease. In polymyositis, the majority of extrafusal muscle fibers of most patients showed strong sarcolemmal class 1 MHCP expression. In dermatomyositis, muscle fibers situated either in perifascicular or in randomly clustered distribution revealed strong class 1 MHCP reactivity. In inclusion body myositis, scattered small clusters of muscle fibers were positive for class 1 MHCP. In polymyositis and inclusion body myositis, particularly strong class 1 MHCP expression was invariably seen in nonnecrotic muscle fibers partially invaded by lymphocytes whose cytotoxic effects are believed to be class 1 MHCP restricted. Factors or agents that trigger class 1 MHCP expression are presumed also to sensitize lymphocytes to muscle fibers in these diseases, but their identity remains obscure at this time. In dermatomyositis, the expression of MHCP in perifascicular muscle fibers and in areas of capillary loss may represent the triggering of MHCP expression by a nonspecific cellular stress reaction, in this case probably low‐grade ischemia.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Karpati, George" sort="Karpati, George" uniqKey="Karpati G" first="George" last="Karpati">George Karpati</name></noRegion><name sortKey="Carpenter, Stirling" sort="Carpenter, Stirling" uniqKey="Carpenter S" first="Stirling" last="Carpenter">Stirling Carpenter</name><name sortKey="Karpati, George" sort="Karpati, George" uniqKey="Karpati G" first="George" last="Karpati">George Karpati</name><name sortKey="Pouliot, Yannick" sort="Pouliot, Yannick" uniqKey="Pouliot Y" first="Yannick" last="Pouliot">Yannick Pouliot</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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