Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Identifieur interne : 001A30 ( Main/Exploration ); précédent : 001A29; suivant : 001A31Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Auteurs : Kai W. Wucherpfennig [États-Unis] ; Jack L. Strominger [États-Unis]Source :
- Cell [ 0092-8674 ] ; 1995.
English descriptors
- Teeft :
- Adenovirus, Aliphatic, Allogeneic feeder cells, Amino, Amino acids, Antigenic, Aromatic residues, Aspartic acid, Autoimmunity, Autoreactive, Bacterial peptides, Cell activation, Cell clone, Cell clones, Cell epitope, Cell epitopes, Cell line, Cell lines, Cell proliferation, Cell receptor, Cell recognition, Cell response, Cell stimulation, Cerebrospinal fluid, Clonal, Clonal expansion, Clone, Contact residues, Cytomegalovirus, Drb1, Epitope, Hemagglutinin, Herpes, Herpes simplex, Immunodominant, Immunodominant myelin, Immunodominant peptide, Immunol, Influenza, Influenza type, Lymphocyte, Lytic cycle, Mimicry, Mimicry epitopes, Mimicry peptide, Mimicry peptides, Molecular mimicry, Multiple sclerosis, Multiple sclerosis patients, Mutational analysis, Myelin, Papillomavirus, Pathogen, Peptide, Peptide conformation, Phorbol, Polymerase, Positive control, Protein peptide, Pseudomonas, Sclerosis, Search criteria, Simplex, Stimulatory, Stimulatory capacity, Structural requirements, Substitution, Subtypes, Viral, Viral mimicry peptides, Viral peptides, Wucherpfennig.
Abstract
Abstract: Structural similarity between viral T cell epitopes and self-peptides could lead to the induction of an autoaggressive T cell response. Based on the structural requirements for both MHC class 11 binding and TCR recognition of an immunodominant myelin basic protein (MBP) peptide, criteria for a data base search were developed in which the degeneracy of amino acid side chains required for MHC class 11 binding and the conservation of those required for T cell activation were considered. A panel of 129 peptides that matched the molecular mimicry motif was tested on seven MBP-specific T cell clones from multiple sclerosis patients. Seven viral and one bacterial peptide efficiently activated three of these clones. Only one peptide could have been identified as a molecular mimic by sequence alignment. The observation that a single T cell receptor can recognize quite distinct but structurally related peptides from multiple pathogens has important implications for understanding the pathogenesis of autoimmunity.
Url:
DOI: 10.1016/0092-8674(95)90348-8
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000888
- to stream Istex, to step Curation: 000855
- to stream Istex, to step Checkpoint: 000437
- to stream Main, to step Merge: 001A46
- to stream Main, to step Curation: 001A30
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein</title><author><name sortKey="Wucherpfennig, Kai W" sort="Wucherpfennig, Kai W" uniqKey="Wucherpfennig K" first="Kai W" last="Wucherpfennig">Kai W. Wucherpfennig</name></author><author><name sortKey="Strominger, Jack L" sort="Strominger, Jack L" uniqKey="Strominger J" first="Jack L" last="Strominger">Jack L. Strominger</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B1572F523C527B4C00D93E43B7B100F47D61DEA0</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0092-8674(95)90348-8</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-5S07CK3V-D/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000888</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000888</idno><idno type="wicri:Area/Istex/Curation">000855</idno><idno type="wicri:Area/Istex/Checkpoint">000437</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000437</idno><idno type="wicri:doubleKey">0092-8674:1995:Wucherpfennig K:molecular:mimicry:in</idno><idno type="wicri:Area/Main/Merge">001A46</idno><idno type="wicri:Area/Main/Curation">001A30</idno><idno type="wicri:Area/Main/Exploration">001A30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein</title><author><name sortKey="Wucherpfennig, Kai W" sort="Wucherpfennig, Kai W" uniqKey="Wucherpfennig K" first="Kai W" last="Wucherpfennig">Kai W. Wucherpfennig</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology Harvard University Cambridge, Massachusetts, 02138</wicri:regionArea><wicri:noRegion>02138</wicri:noRegion></affiliation></author><author><name sortKey="Strominger, Jack L" sort="Strominger, Jack L" uniqKey="Strominger J" first="Jack L" last="Strominger">Jack L. Strominger</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology Harvard University Cambridge, Massachusetts, 02138</wicri:regionArea><wicri:noRegion>02138</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="695">695</biblScope><biblScope unit="page" to="705">705</biblScope></imprint><idno type="ISSN">0092-8674</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenovirus</term><term>Aliphatic</term><term>Allogeneic feeder cells</term><term>Amino</term><term>Amino acids</term><term>Antigenic</term><term>Aromatic residues</term><term>Aspartic acid</term><term>Autoimmunity</term><term>Autoreactive</term><term>Bacterial peptides</term><term>Cell activation</term><term>Cell clone</term><term>Cell clones</term><term>Cell epitope</term><term>Cell epitopes</term><term>Cell line</term><term>Cell lines</term><term>Cell proliferation</term><term>Cell receptor</term><term>Cell recognition</term><term>Cell response</term><term>Cell stimulation</term><term>Cerebrospinal fluid</term><term>Clonal</term><term>Clonal expansion</term><term>Clone</term><term>Contact residues</term><term>Cytomegalovirus</term><term>Drb1</term><term>Epitope</term><term>Hemagglutinin</term><term>Herpes</term><term>Herpes simplex</term><term>Immunodominant</term><term>Immunodominant myelin</term><term>Immunodominant peptide</term><term>Immunol</term><term>Influenza</term><term>Influenza type</term><term>Lymphocyte</term><term>Lytic cycle</term><term>Mimicry</term><term>Mimicry epitopes</term><term>Mimicry peptide</term><term>Mimicry peptides</term><term>Molecular mimicry</term><term>Multiple sclerosis</term><term>Multiple sclerosis patients</term><term>Mutational analysis</term><term>Myelin</term><term>Papillomavirus</term><term>Pathogen</term><term>Peptide</term><term>Peptide conformation</term><term>Phorbol</term><term>Polymerase</term><term>Positive control</term><term>Protein peptide</term><term>Pseudomonas</term><term>Sclerosis</term><term>Search criteria</term><term>Simplex</term><term>Stimulatory</term><term>Stimulatory capacity</term><term>Structural requirements</term><term>Substitution</term><term>Subtypes</term><term>Viral</term><term>Viral mimicry peptides</term><term>Viral peptides</term><term>Wucherpfennig</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Structural similarity between viral T cell epitopes and self-peptides could lead to the induction of an autoaggressive T cell response. Based on the structural requirements for both MHC class 11 binding and TCR recognition of an immunodominant myelin basic protein (MBP) peptide, criteria for a data base search were developed in which the degeneracy of amino acid side chains required for MHC class 11 binding and the conservation of those required for T cell activation were considered. A panel of 129 peptides that matched the molecular mimicry motif was tested on seven MBP-specific T cell clones from multiple sclerosis patients. Seven viral and one bacterial peptide efficiently activated three of these clones. Only one peptide could have been identified as a molecular mimic by sequence alignment. The observation that a single T cell receptor can recognize quite distinct but structurally related peptides from multiple pathogens has important implications for understanding the pathogenesis of autoimmunity.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Wucherpfennig, Kai W" sort="Wucherpfennig, Kai W" uniqKey="Wucherpfennig K" first="Kai W" last="Wucherpfennig">Kai W. Wucherpfennig</name></noRegion><name sortKey="Strominger, Jack L" sort="Strominger, Jack L" uniqKey="Strominger J" first="Jack L" last="Strominger">Jack L. Strominger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A30 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A30 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B1572F523C527B4C00D93E43B7B100F47D61DEA0
|texte= Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
}}
| This area was generated with Dilib version V0.6.33. |  |