Actinobacillus pleuropneumoniae serotype 2—effects on the interferon- α production of porcine leukocytes in vivo and in vitro
Identifieur interne : 001984 ( Main/Exploration ); précédent : 001983; suivant : 001985Actinobacillus pleuropneumoniae serotype 2—effects on the interferon- α production of porcine leukocytes in vivo and in vitro
Auteurs : Eva Wattrang [Suède] ; P. Wallgren [Suède] ; Caroline Fossum [Suède]Source :
- Comparative Immunology, Microbiology and Infectious Diseases [ 0147-9571 ] ; 1998.
English descriptors
- Teeft :
- Actinobacillus, Actinobacillus pleuropneumoniae, Adherent cells, Agricultural sciences, Bacterial infection, Bacterial infections, Bacterial preparations, Chemiluminescence, Comp, Comparative studies, Cytokine, Cytokine production, Disease virus, Elsevier science, Experimental groups, Experimental infection, Experimental period, Experimental pigs, Febrile stage, Fossum, Functional capacity, Growth medium, Heparinized blood, Herpes simplex virus, Human pbmc, Immun, Immune, Immune response, Immunol, Immunopathol, Inducer, Infection, Interferon, Interferon cytokine, Interferon system, Leukocyte, Microbiol, Nasal secretion, Neutrophil, Pbmc, Pig, Pleuropneumoniae, Pleuropneumoniae serotype, Pmnl, Porcine, Porcine leukocytes, Present study, Swedish university, Total number, Uninfected, Uninfected pigs, Viral, Wattrang, Whole blood, Whole blood cultures.
Abstract
Abstract: Effects of a bacterial infection on the IFN-α production in vivo and in vitro were studied in eight specific pathogen free pigs experimentally infected with Actinobacillus pleuropneumoniae. Clinically, the experimental infection was manifested as a febrile stage which lasted approximately one week and by signs of respiratory disease. The Aujeszky’s disease virus (ADV) induced IFN-α production, assessed in whole blood cultures, was increased for the infected pigs during the febrile stage. Potentiating effects on the IFN-α production could be transferred to cultures of purified peripheral blood mononuclear cells with sera collected from the infected pigs during this period of time. Although the experimental infection with A. pleuropneumoniae did not induce any detectable amounts of IFN-α in serum or nasal secretion, both a phenol-extract and a heat-inactivated preparation of the bacteria induced low levels of IFN-α in cultures of purified PBMC. The interferogenic structures of the bacteria were not identified but there were indications that the bacteria induced IFN-α production in the same cell type as ADV.
Résumé: Huit porcs exemptsd’organismes pathogènes spécifiques et infectés expérimentalement par Actinobacillus pleuropneumoniae, on étéutilisés dans le butd’étudier les effetsd’une infection bactérienne sur la productiond’IFN-α in vivo et in vitro. Les effets cliniques del’infection expérimentale induent un état fébrile persistant environ une semaine ainsi que des symptômes respiratoires. La productiond’IFN-α induite par le virus de la maladied’Aujeszky (ADV), déterminée àpartir de cultures de sang total, a étéaugmentée chez les animaux infectés, pendant la phase fébrile. L’effet potentialiseur del’infection bactérienne sur la productiond’IFN-α a pu être transféréàdes cultures de cellules mononuclées du sang périphérique par dessérumsd’animaux infectés collectés pendant cette phase fébrile. L’infection expérimentale par A. pleuropneumoniae n’a pas induit la production de quantitésd’IFN-αdétectables dans lesérum ou lessécrétions nasales. Un extrait phénolique bactérien ou une préparation bactérienne inactivée par la chaleur ont induit une faible productiond’IFN-α par des leucocytes purifiés du sang périphérique. Les structures interferogénes de la bacteria n’ont pas étéidentifiées, mais il semble que A. pleuropneumoniae a induit la productiond’IFN-α par lemême type cellulaire que ADV.
Url:
DOI: 10.1016/S0147-9571(97)00025-8
Affiliations:
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Le document en format XML
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Wallgren</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>The National Veterinary Institute, Box 7073, S-750 07 Uppsala</wicri:regionArea><wicri:noRegion>S-750 07 Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Fossum, Caroline" sort="Fossum, Caroline" uniqKey="Fossum C" first="Caroline" last="Fossum">Caroline Fossum</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Veterinary Microbiology, Division of Immunology, Swedish University of Agricultural Sciences, BMC, Box 588, S-751 23 Uppsala</wicri:regionArea><wicri:noRegion>S-751 23 Uppsala</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Comparative Immunology, Microbiology and Infectious Diseases</title><title level="j" type="abbrev">CIMID</title><idno type="ISSN">0147-9571</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="135">135</biblScope><biblScope unit="page" to="154">154</biblScope></imprint><idno type="ISSN">0147-9571</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0147-9571</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Actinobacillus</term><term>Actinobacillus pleuropneumoniae</term><term>Adherent cells</term><term>Agricultural sciences</term><term>Bacterial infection</term><term>Bacterial infections</term><term>Bacterial preparations</term><term>Chemiluminescence</term><term>Comp</term><term>Comparative studies</term><term>Cytokine</term><term>Cytokine production</term><term>Disease virus</term><term>Elsevier science</term><term>Experimental groups</term><term>Experimental infection</term><term>Experimental period</term><term>Experimental pigs</term><term>Febrile stage</term><term>Fossum</term><term>Functional capacity</term><term>Growth medium</term><term>Heparinized blood</term><term>Herpes simplex virus</term><term>Human pbmc</term><term>Immun</term><term>Immune</term><term>Immune response</term><term>Immunol</term><term>Immunopathol</term><term>Inducer</term><term>Infection</term><term>Interferon</term><term>Interferon cytokine</term><term>Interferon system</term><term>Leukocyte</term><term>Microbiol</term><term>Nasal secretion</term><term>Neutrophil</term><term>Pbmc</term><term>Pig</term><term>Pleuropneumoniae</term><term>Pleuropneumoniae serotype</term><term>Pmnl</term><term>Porcine</term><term>Porcine leukocytes</term><term>Present study</term><term>Swedish university</term><term>Total number</term><term>Uninfected</term><term>Uninfected pigs</term><term>Viral</term><term>Wattrang</term><term>Whole blood</term><term>Whole blood cultures</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Effects of a bacterial infection on the IFN-α production in vivo and in vitro were studied in eight specific pathogen free pigs experimentally infected with Actinobacillus pleuropneumoniae. Clinically, the experimental infection was manifested as a febrile stage which lasted approximately one week and by signs of respiratory disease. The Aujeszky’s disease virus (ADV) induced IFN-α production, assessed in whole blood cultures, was increased for the infected pigs during the febrile stage. Potentiating effects on the IFN-α production could be transferred to cultures of purified peripheral blood mononuclear cells with sera collected from the infected pigs during this period of time. Although the experimental infection with A. pleuropneumoniae did not induce any detectable amounts of IFN-α in serum or nasal secretion, both a phenol-extract and a heat-inactivated preparation of the bacteria induced low levels of IFN-α in cultures of purified PBMC. The interferogenic structures of the bacteria were not identified but there were indications that the bacteria induced IFN-α production in the same cell type as ADV.</div><div type="abstract" xml:lang="fr">Résumé: Huit porcs exemptsd’organismes pathogènes spécifiques et infectés expérimentalement par Actinobacillus pleuropneumoniae, on étéutilisés dans le butd’étudier les effetsd’une infection bactérienne sur la productiond’IFN-α in vivo et in vitro. Les effets cliniques del’infection expérimentale induent un état fébrile persistant environ une semaine ainsi que des symptômes respiratoires. La productiond’IFN-α induite par le virus de la maladied’Aujeszky (ADV), déterminée àpartir de cultures de sang total, a étéaugmentée chez les animaux infectés, pendant la phase fébrile. L’effet potentialiseur del’infection bactérienne sur la productiond’IFN-α a pu être transféréàdes cultures de cellules mononuclées du sang périphérique par dessérumsd’animaux infectés collectés pendant cette phase fébrile. L’infection expérimentale par A. pleuropneumoniae n’a pas induit la production de quantitésd’IFN-αdétectables dans lesérum ou lessécrétions nasales. Un extrait phénolique bactérien ou une préparation bactérienne inactivée par la chaleur ont induit une faible productiond’IFN-α par des leucocytes purifiés du sang périphérique. Les structures interferogénes de la bacteria n’ont pas étéidentifiées, mais il semble que A. pleuropneumoniae a induit la productiond’IFN-α par lemême type cellulaire que ADV.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Wattrang, Eva" sort="Wattrang, Eva" uniqKey="Wattrang E" first="Eva" last="Wattrang">Eva Wattrang</name></noRegion><name sortKey="Fossum, Caroline" sort="Fossum, Caroline" uniqKey="Fossum C" first="Caroline" last="Fossum">Caroline Fossum</name><name sortKey="Wallgren, P" sort="Wallgren, P" uniqKey="Wallgren P" first="P." last="Wallgren">P. Wallgren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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