Glial grafting for demyelinating disease
Identifieur interne : 001759 ( Main/Exploration ); précédent : 001758; suivant : 001760Glial grafting for demyelinating disease
Auteurs : V. Tepav Evi ; W. F BlakemoreSource :
- Philosophical Transactions of the Royal Society B: Biological Sciences [ 0962-8436 ] ; 2005.
Abstract
Remyelination of demyelinated central nervous system (CNS) axons is considered as a potential treatment for multiple sclerosis, and it has been achieved in experimental models of demyelination by transplantation of pro-myelinating cells. However, the experiments undertaken have not addressed the need for tissue-type matching in order to achieve graft-mediated remyelination since they were performed in conditions in which the chance for graft rejection was minimized. This article focuses on the factors determining survival of allogeneic oligodendrocyte lineage cells and their contribution to the remyelination of demyelinating CNS lesions. The immune status of the CNS as well as the suitability of different models of demyelination for graft rejection studies are discussed, and ways of enhancing allogeneic oligodendrocyte-mediated remyelination are presented. Finally, the effects of glial graft rejection on host remyelination are described, highlighting the potential benefits of the acute CNS inflammatory response for myelin repair.
Url:
DOI: 10.1098/rstb.2005.1700
PubMed: 16147541
PubMed Central: 1569542
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000727
- to stream Pmc, to step Curation: 000727
- to stream Pmc, to step Checkpoint: 000985
- to stream Ncbi, to step Merge: 000070
- to stream Ncbi, to step Curation: 000070
- to stream Ncbi, to step Checkpoint: 000070
- to stream Main, to step Merge: 001768
- to stream Main, to step Curation: 001759
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glial grafting for demyelinating disease</title><author><name sortKey="Tepav Evi, V" sort="Tepav Evi, V" uniqKey="Tepav Evi V" first="V" last="Tepav Evi">V. Tepav Evi</name></author><author><name sortKey="Blakemore, W F" sort="Blakemore, W F" uniqKey="Blakemore W" first="W. F" last="Blakemore">W. F Blakemore</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16147541</idno><idno type="pmc">1569542</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569542</idno><idno type="RBID">PMC:1569542</idno><idno type="doi">10.1098/rstb.2005.1700</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000727</idno><idno type="wicri:Area/Pmc/Curation">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000727</idno><idno type="wicri:Area/Pmc/Checkpoint">000985</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000985</idno><idno type="wicri:Area/Ncbi/Merge">000070</idno><idno type="wicri:Area/Ncbi/Curation">000070</idno><idno type="wicri:Area/Ncbi/Checkpoint">000070</idno><idno type="wicri:doubleKey">0962-8436:2005:Tepav Evi V:glial:grafting:for</idno><idno type="wicri:Area/Main/Merge">001768</idno><idno type="wicri:Area/Main/Curation">001759</idno><idno type="wicri:Area/Main/Exploration">001759</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Glial grafting for demyelinating disease</title><author><name sortKey="Tepav Evi, V" sort="Tepav Evi, V" uniqKey="Tepav Evi V" first="V" last="Tepav Evi">V. Tepav Evi</name></author><author><name sortKey="Blakemore, W F" sort="Blakemore, W F" uniqKey="Blakemore W" first="W. F" last="Blakemore">W. F Blakemore</name></author></analytic><series><title level="j">Philosophical Transactions of the Royal Society B: Biological Sciences</title><idno type="ISSN">0962-8436</idno><idno type="eISSN">1471-2970</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Remyelination of demyelinated central nervous system (CNS) axons is considered as a potential treatment for multiple sclerosis, and it has been achieved in experimental models of demyelination by transplantation of pro-myelinating cells. However, the experiments undertaken have not addressed the need for tissue-type matching in order to achieve graft-mediated remyelination since they were performed in conditions in which the chance for graft rejection was minimized. This article focuses on the factors determining survival of allogeneic oligodendrocyte lineage cells and their contribution to the remyelination of demyelinating CNS lesions. The immune status of the CNS as well as the suitability of different models of demyelination for graft rejection studies are discussed, and ways of enhancing allogeneic oligodendrocyte-mediated remyelination are presented. Finally, the effects of glial graft rejection on host remyelination are described, highlighting the potential benefits of the acute CNS inflammatory response for myelin repair.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Blakemore, W F" sort="Blakemore, W F" uniqKey="Blakemore W" first="W. F" last="Blakemore">W. F Blakemore</name><name sortKey="Tepav Evi, V" sort="Tepav Evi, V" uniqKey="Tepav Evi V" first="V" last="Tepav Evi">V. Tepav Evi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001759 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001759 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:1569542
|texte= Glial grafting for demyelinating disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16147541" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |