Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
Identifieur interne : 001259 ( Main/Exploration ); précédent : 001258; suivant : 001260Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
Auteurs : Andy Kilianski ; Susan C. BakerSource :
- Antiviral research [ 0166-3542 ] ; 2013.
Abstract
To combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-CoV activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The recent emergence of the Middle East respiratory syndrome (MERS)-CoV necessitates adapting methods that have been used to identify antivirals against the severe, acute respiratory syndrome (SARS)-CoV and developing new approaches to more efficiently screen antiviral drugs. In this article we review cell-based assays using infectious virus (BSL-3) and surrogate assays (BSL-2) that can be implemented to accelerate antiviral development against MERS-CoV and future emergent coronaviruses. This paper forms part of a series of invited articles in
Url:
DOI: 10.1016/j.antiviral.2013.11.004
PubMed: 24269477
PubMed Central: 3931262
Affiliations:
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