Gene-expression reversal of lncRNAs and associated mRNAs expression in active vs latent HIV infection
Identifieur interne : 000F82 ( Main/Exploration ); précédent : 000F81; suivant : 000F83Gene-expression reversal of lncRNAs and associated mRNAs expression in active vs latent HIV infection
Auteurs : Madhavan Nair ; Vidya Sagar ; Sudheesh Pilakka-KanthikeelSource :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Interplay between lncRNAs and mRNAs is rapidly emerging as a key epigenetic mechanism in controlling various cell functions. HIV can actively infect and/or can persist latently for years by manipulating host epigenetics; however, its molecular essence remains undiscovered in entirety. Here for the first time, we delineate the influence of HIV on global lncRNAs expression in monocytic cells lines. Our analysis revealed the expression modulation of nearly 1060 such lncRNAs which are associated with differentially expressed mRNAs in active and latent infection. This suggests a greater role of lncRNAs in regulating transcriptional and post-transcriptional gene expression during HIV infection. The differentially expressed mRNAs were involved in several different biological pathways where immunological networks were most enriched. Importantly, we discovered that HIV induces expression reversal of more than 150 lncRNAs between its active and latent infection. Also, hundreds of unique lncRNAs were identified in both infection conditions. The pathology specific “gene-expression reversal” and “on-and-off” switching of lncRNAs and associated mRNAs may lead to establish the relationship between active and HIV infection.
The online version of this article (doi:10.1038/srep34862) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/srep34862
PubMed: 27756902
PubMed Central: 5069461
Affiliations:
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University,</institution></institution-wrap>Miami, FL-33199 USA</nlm:aff><wicri:noCountry code="subfield">FL-33199 USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.65456.34</institution-id><institution-id institution-id-type="ISNI">0000 0001 2110 1845</institution-id><institution>Institute of Neuro-Immune Pharmacology, Herbert Wertheim College of Medicine, Florida International University,</institution></institution-wrap>Miami, FL-33199 USA</nlm:aff><wicri:noCountry code="subfield">FL-33199 USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.65456.34</institution-id><institution-id institution-id-type="ISNI">0000 0001 2110 1845</institution-id><institution>Center for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University,</institution></institution-wrap>Miami, FL-33199 USA</nlm:aff><wicri:noCountry code="subfield">FL-33199 USA</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Interplay between lncRNAs and mRNAs is rapidly emerging as a key epigenetic mechanism in controlling various cell functions. HIV can actively infect and/or can persist latently for years by manipulating host epigenetics; however, its molecular essence remains undiscovered in entirety. Here for the first time, we delineate the influence of HIV on global lncRNAs expression in monocytic cells lines. Our analysis revealed the expression modulation of nearly 1060 such lncRNAs which are associated with differentially expressed mRNAs in active and latent infection. This suggests a greater role of lncRNAs in regulating transcriptional and post-transcriptional gene expression during HIV infection. The differentially expressed mRNAs were involved in several different biological pathways where immunological networks were most enriched. Importantly, we discovered that HIV induces expression reversal of more than 150 lncRNAs between its active and latent infection. Also, hundreds of unique lncRNAs were identified in both infection conditions. The pathology specific “gene-expression reversal” and “on-and-off” switching of lncRNAs and associated mRNAs may lead to establish the relationship between active and HIV infection.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1038/srep34862) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hellmuth, J" uniqKey="Hellmuth J">J Hellmuth</name></author><author><name sortKey="Valcour, V" uniqKey="Valcour V">V Valcour</name></author><author><name sortKey="Spudich, S" uniqKey="Spudich S">S Spudich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacha, Jb" uniqKey="Sacha J">JB 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