Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study
Identifieur interne : 000E72 ( Main/Exploration ); précédent : 000E71; suivant : 000E73Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study
Auteurs : Alfred M. Legendre [États-Unis] ; Tanya Kuritz [États-Unis] ; Gina Galyon [États-Unis] ; Vivian M. Baylor [États-Unis] ; Robert Eric Heidel [États-Unis]Source :
- Frontiers in Veterinary Science [ 2297-1769 ] ; 2017.
Abstract
Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria, were treated with PI without intentional selection of less severe cases. The survival time from the start of PI treatment in cats diagnosed with dry FIP showed that of the 60 cats with dry FIP treated with PI, 8 survived over 200 days, and 4 of 60 survived over 300 days. A literature search identified 59 cats with non-effusive or dry FIP; no cat with only dry FIP lived longer than 200 days. Veterinarians of cats treated with PI that survived over 30 days reported improvements in clinical signs and behavior. The survival times in our study were significantly longer in cats who were not treated with corticosteroids concurrently with PI. While not a cure, PI shows promise in the treatment of dry form FIP, but a controlled study will be needed to verify the benefit.
Url:
DOI: 10.3389/fvets.2017.00007
PubMed: 28261584
PubMed Central: 5306384
Affiliations:
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Legendre</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee</institution>,<addr-line>Knoxville, TN</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuritz, Tanya" sort="Kuritz, Tanya" uniqKey="Kuritz T" first="Tanya" last="Kuritz">Tanya Kuritz</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Sass & Sass, Inc.</institution>,<addr-line>Oak Ridge, TN</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Galyon, Gina" sort="Galyon, Gina" uniqKey="Galyon G" first="Gina" last="Galyon">Gina Galyon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee</institution>,<addr-line>Knoxville, TN</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baylor, Vivian M" sort="Baylor, Vivian M" uniqKey="Baylor V" first="Vivian M." last="Baylor">Vivian M. Baylor</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Independent Consultant</institution>,<addr-line>Oak Ridge, TN</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heidel, Robert Eric" sort="Heidel, Robert Eric" uniqKey="Heidel R" first="Robert Eric" last="Heidel">Robert Eric Heidel</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Graduate School of Medicine, University of Tennessee</institution>,<addr-line>Knoxville, TN</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Veterinary Science</title><idno type="eISSN">2297-1769</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria, were treated with PI without intentional selection of less severe cases. The survival time from the start of PI treatment in cats diagnosed with dry FIP showed that of the 60 cats with dry FIP treated with PI, 8 survived over 200 days, and 4 of 60 survived over 300 days. A literature search identified 59 cats with non-effusive or dry FIP; no cat with only dry FIP lived longer than 200 days. Veterinarians of cats treated with PI that survived over 30 days reported improvements in clinical signs and behavior. The survival times in our study were significantly longer in cats who were not treated with corticosteroids concurrently with PI. While not a cure, PI shows promise in the treatment of dry form FIP, but a controlled study will be needed to verify the benefit.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Addie, Dd" uniqKey="Addie D">DD Addie</name></author><author><name sortKey="Jarrett, O" uniqKey="Jarrett O">O Jarrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Addie, D" uniqKey="Addie D">D Addie</name></author><author><name sortKey="Belak, S" uniqKey="Belak S">S Belák</name></author><author><name sortKey="Boucraut Baralon, C" uniqKey="Boucraut Baralon C">C Boucraut-Baralon</name></author><author><name sortKey="Egberink, H" uniqKey="Egberink H">H Egberink</name></author><author><name sortKey="Frymus, T" uniqKey="Frymus T">T Frymus</name></author><author><name sortKey="Gruffydd Jones, T" uniqKey="Gruffydd Jones T">T Gruffydd-Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Groot</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Legendre, Alfred M" sort="Legendre, Alfred M" uniqKey="Legendre A" first="Alfred M." last="Legendre">Alfred M. Legendre</name></noRegion><name sortKey="Baylor, Vivian M" sort="Baylor, Vivian M" uniqKey="Baylor V" first="Vivian M." last="Baylor">Vivian M. Baylor</name><name sortKey="Galyon, Gina" sort="Galyon, Gina" uniqKey="Galyon G" first="Gina" last="Galyon">Gina Galyon</name><name sortKey="Heidel, Robert Eric" sort="Heidel, Robert Eric" uniqKey="Heidel R" first="Robert Eric" last="Heidel">Robert Eric Heidel</name><name sortKey="Kuritz, Tanya" sort="Kuritz, Tanya" uniqKey="Kuritz T" first="Tanya" last="Kuritz">Tanya Kuritz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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