Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children
Identifieur interne : 000E60 ( Main/Exploration ); précédent : 000E59; suivant : 000E61Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children
Auteurs : Yoon Young Jang ; Hye Jin Park ; Hai Lee ChungSource :
- European Journal of Pediatrics [ 0340-6199 ] ; 2017.
Abstract
Children with post-infectious bronchiolitis obliterans (PIBO) are frequently hospitalized with acute exacerbation, but clinical differentiation of PIBO exacerbation from acute bronchiolitis is often challenging, which may result in treatment delay and chronic lung function impairment. We aimed to examine whether serum YKL-40 and growth factors could be markers for PIBO exacerbation. Thirty-seven children admitted with acute exacerbation of PIBO were enrolled and studied retrospectively. Diagnosis of PIBO was based on clinical history of acute respiratory infection followed by persistent airway obstruction and characteristic findings in high-resolution computed tomography. Serum levels of YKL-40, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and platelet-derived growth factor (PDGF)-BB were measured on admission. The biomarkers were also examined in children admitted with acute bronchiolitis serving as positive controls (
Url:
DOI: 10.1007/s00431-017-2940-x
PubMed: 28567534
PubMed Central: 7087271
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children</title><author><name sortKey="Jang, Yoon Young" sort="Jang, Yoon Young" uniqKey="Jang Y" first="Yoon Young" last="Jang">Yoon Young Jang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Park, Hye Jin" sort="Park, Hye Jin" uniqKey="Park H" first="Hye Jin" last="Park">Hye Jin Park</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Chung, Hai Lee" sort="Chung, Hai Lee" uniqKey="Chung H" first="Hai Lee" last="Chung">Hai Lee Chung</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28567534</idno><idno type="pmc">7087271</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087271</idno><idno type="RBID">PMC:7087271</idno><idno type="doi">10.1007/s00431-017-2940-x</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000255</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000255</idno><idno type="wicri:Area/Pmc/Curation">000255</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000255</idno><idno type="wicri:Area/Pmc/Checkpoint">000366</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000366</idno><idno type="wicri:Area/Ncbi/Merge">000710</idno><idno type="wicri:Area/Ncbi/Curation">000710</idno><idno type="wicri:Area/Ncbi/Checkpoint">000710</idno><idno type="wicri:doubleKey">0340-6199:2017:Jang Y:serum:ykl:levels</idno><idno type="wicri:Area/Main/Merge">000E62</idno><idno type="wicri:Area/Main/Curation">000E60</idno><idno type="wicri:Area/Main/Exploration">000E60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children</title><author><name sortKey="Jang, Yoon Young" sort="Jang, Yoon Young" uniqKey="Jang Y" first="Yoon Young" last="Jang">Yoon Young Jang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Park, Hye Jin" sort="Park, Hye Jin" uniqKey="Park H" first="Hye Jin" last="Park">Hye Jin Park</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Chung, Hai Lee" sort="Chung, Hai Lee" uniqKey="Chung H" first="Hai Lee" last="Chung">Hai Lee Chung</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">European Journal of Pediatrics</title><idno type="ISSN">0340-6199</idno><idno type="eISSN">1432-1076</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Children with post-infectious bronchiolitis obliterans (PIBO) are frequently hospitalized with acute exacerbation, but clinical differentiation of PIBO exacerbation from acute bronchiolitis is often challenging, which may result in treatment delay and chronic lung function impairment. We aimed to examine whether serum YKL-40 and growth factors could be markers for PIBO exacerbation. Thirty-seven children admitted with acute exacerbation of PIBO were enrolled and studied retrospectively. Diagnosis of PIBO was based on clinical history of acute respiratory infection followed by persistent airway obstruction and characteristic findings in high-resolution computed tomography. Serum levels of YKL-40, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and platelet-derived growth factor (PDGF)-BB were measured on admission. The biomarkers were also examined in children admitted with acute bronchiolitis serving as positive controls (<italic>N</italic> = 30) and in age-matched controls (<italic>N</italic> = 20). Only YKL-40 levels were found to be significantly higher in PIBO patients with exacerbation compared with that in bronchiolitis patients and showed a positive correlation with the severity of disease before diagnosis of PIBO.</p><p id="Par2"><italic>Conclusion</italic>: Our results suggest that measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children.<table-wrap id="Taba"><table frame="hsides" rules="groups"><tbody><tr><td><p><bold>What is Known:</bold></p><p><italic>• The children with post-infectious BO (PIBO) usually have recurrent wheezing and need frequent hospitalization due to acute exacerbation during the first disease years.</italic></p><p><italic>• Clinical differentiation of PIBO exacerbation from acute bronchiolitis in young children is often challenging, which may result in treatment delay and chronic lung function impairment.</italic></p></td></tr><tr><td><p><bold>What is New:</bold></p><p><italic>• Measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children.</italic></p></td></tr></tbody></table></table-wrap></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moonnumakal, Sp" uniqKey="Moonnumakal S">SP Moonnumakal</name></author><author><name sortKey="Fan, Ll" uniqKey="Fan L">LL Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barker, Af" uniqKey="Barker A">AF Barker</name></author><author><name sortKey="Bergeron, A" uniqKey="Bergeron A">A Bergeron</name></author><author><name sortKey="Rom, Wn" uniqKey="Rom W">WN Rom</name></author><author><name sortKey="Hertz, Mi" uniqKey="Hertz M">MI Hertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, Gb" uniqKey="Fischer G">GB Fischer</name></author><author><name sortKey="Sarria, Ee" uniqKey="Sarria E">EE Sarria</name></author><author><name sortKey="Mattiello, 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