Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study
Identifieur interne : 000E57 ( Main/Exploration ); précédent : 000E56; suivant : 000E58Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study
Auteurs : Anirban Ghosh ; Dipita Bhattacharyya ; Anirban BhuniaSource :
- Biochimica et Biophysica Acta. Biomembranes [ 0005-2736 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Dichroïsme circulaire, Dodécyl-sulfate de sodium (), Double couche lipidique (), Double couche lipidique (métabolisme), Humains, Liaison aux protéines, Liposomes unilamellaires (), Liposomes unilamellaires (métabolisme), Micelles, Modèles moléculaires, Oligopeptides (), Oligopeptides (métabolisme), Phosphoryl-choline (), Phosphoryl-choline (analogues et dérivés), Protéines de l'enveloppe virale (), Spectroscopie par résonance magnétique, Structure secondaire des protéines, Séquence d'acides aminés.
- MESH :
- analogues et dérivés : Phosphoryl-choline.
- métabolisme : Double couche lipidique, Liposomes unilamellaires, Oligopeptides.
- Animaux, Dichroïsme circulaire, Dodécyl-sulfate de sodium, Double couche lipidique, Humains, Liaison aux protéines, Liposomes unilamellaires, Micelles, Modèles moléculaires, Oligopeptides, Phosphoryl-choline, Protéines de l'enveloppe virale, Spectroscopie par résonance magnétique, Structure secondaire des protéines, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Circular Dichroism, Humans, Lipid Bilayers (chemistry), Lipid Bilayers (metabolism), Magnetic Resonance Spectroscopy, Micelles, Models, Molecular, Oligopeptides (chemistry), Oligopeptides (metabolism), Phosphorylcholine (analogs & derivatives), Phosphorylcholine (chemistry), Protein Binding, Protein Structure, Secondary, Sodium Dodecyl Sulfate (chemistry), Unilamellar Liposomes (chemistry), Unilamellar Liposomes (metabolism), Viral Envelope Proteins (chemistry).
- MESH :
- chemical , analogs & derivatives : Phosphorylcholine.
- chemical , chemistry : Lipid Bilayers, Oligopeptides, Phosphorylcholine, Sodium Dodecyl Sulfate, Unilamellar Liposomes, Viral Envelope Proteins.
- chemical , metabolism : Lipid Bilayers, Oligopeptides, Unilamellar Liposomes.
- Amino Acid Sequence, Animals, Circular Dichroism, Humans, Magnetic Resonance Spectroscopy, Micelles, Models, Molecular, Protein Binding, Protein Structure, Secondary.
Abstract
In recent years, several studies based on the interaction of self-assembling short peptides derived from viroporins with model membranes, have improved our understanding of the molecular mechanism of corona virus (CoV) infection under physiological conditions. In this study, we have characterized the mechanism of membrane interaction of a short, 9-residue peptide TK9 (T55VYVYSRVK63) that had been derived from the carboxyl terminal of the Severe Acute Respiratory Syndrome (SARS) corona virus (SARS CoV) envelope (E) protein. The peptide has been studied for its physical changes in the presence of both zwitterionic DPC and negatively charged SDS model membrane micelles, respectively, with the help of a battery of biophysical techniques including two-dimensional solution state NMR spectroscopy. Interestingly, in both micellar environments, TK9 adopted an alpha helical conformation; however, the helical propensities were much higher in the case of DPC compared to those of SDS micelle, suggesting that TK9 has more specificity towards eukaryotic cell membrane than the bacterial cell membrane. The orientation of the peptide TK9 also varies in the different micellar environments. The peptide's affinity was further manifested by its pronounced membrane disruption ability towards the mammalian compared to the bacterial membrane mimic. Collectively, the in-depth structural information on the interaction of TK9 with different membrane environments explains the host specificity and membrane orientation owing to subsequent membrane disruption implicated in the viral pathogenesis.
Url:
DOI: 10.1016/j.bbamem.2017.10.015
PubMed: 29038024
PubMed Central: 7094419
Affiliations:
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Biomembranes</title><idno type="ISSN">0005-2736</idno><idno type="eISSN">1879-2642</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Circular Dichroism</term><term>Humans</term><term>Lipid Bilayers (chemistry)</term><term>Lipid Bilayers (metabolism)</term><term>Magnetic Resonance Spectroscopy</term><term>Micelles</term><term>Models, Molecular</term><term>Oligopeptides (chemistry)</term><term>Oligopeptides (metabolism)</term><term>Phosphorylcholine (analogs & derivatives)</term><term>Phosphorylcholine (chemistry)</term><term>Protein Binding</term><term>Protein Structure, Secondary</term><term>Sodium Dodecyl Sulfate (chemistry)</term><term>Unilamellar Liposomes (chemistry)</term><term>Unilamellar Liposomes (metabolism)</term><term>Viral Envelope Proteins (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Dichroïsme circulaire</term><term>Dodécyl-sulfate de sodium ()</term><term>Double couche lipidique ()</term><term>Double couche lipidique (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Liposomes unilamellaires ()</term><term>Liposomes unilamellaires (métabolisme)</term><term>Micelles</term><term>Modèles moléculaires</term><term>Oligopeptides ()</term><term>Oligopeptides (métabolisme)</term><term>Phosphoryl-choline ()</term><term>Phosphoryl-choline (analogues et dérivés)</term><term>Protéines de l'enveloppe virale ()</term><term>Spectroscopie par résonance magnétique</term><term>Structure secondaire des protéines</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Phosphorylcholine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Lipid Bilayers</term><term>Oligopeptides</term><term>Phosphorylcholine</term><term>Sodium Dodecyl Sulfate</term><term>Unilamellar Liposomes</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lipid Bilayers</term><term>Oligopeptides</term><term>Unilamellar Liposomes</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Phosphoryl-choline</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Double couche lipidique</term><term>Liposomes unilamellaires</term><term>Oligopeptides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Circular Dichroism</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Micelles</term><term>Models, Molecular</term><term>Protein Binding</term><term>Protein Structure, Secondary</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dichroïsme circulaire</term><term>Dodécyl-sulfate de sodium</term><term>Double couche lipidique</term><term>Humains</term><term>Liaison aux protéines</term><term>Liposomes unilamellaires</term><term>Micelles</term><term>Modèles moléculaires</term><term>Oligopeptides</term><term>Phosphoryl-choline</term><term>Protéines de l'enveloppe virale</term><term>Spectroscopie par résonance magnétique</term><term>Structure secondaire des protéines</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In recent years, several studies based on the interaction of self-assembling short peptides derived from viroporins with model membranes, have improved our understanding of the molecular mechanism of corona virus (CoV) infection under physiological conditions. In this study, we have characterized the mechanism of membrane interaction of a short, 9-residue peptide TK9 (T<sup>55</sup>VYVYSRVK<sup>63</sup>) that had been derived from the carboxyl terminal of the Severe Acute Respiratory Syndrome (SARS) corona virus (SARS CoV) envelope (E) protein. The peptide has been studied for its physical changes in the presence of both zwitterionic DPC and negatively charged SDS model membrane micelles, respectively, with the help of a battery of biophysical techniques including two-dimensional solution state NMR spectroscopy. Interestingly, in both micellar environments, TK9 adopted an alpha helical conformation; however, the helical propensities were much higher in the case of DPC compared to those of SDS micelle, suggesting that TK9 has more specificity towards eukaryotic cell membrane than the bacterial cell membrane. The orientation of the peptide TK9 also varies in the different micellar environments. The peptide's affinity was further manifested by its pronounced membrane disruption ability towards the mammalian compared to the bacterial membrane mimic. Collectively, the in-depth structural information on the interaction of TK9 with different membrane environments explains the host specificity and membrane orientation owing to subsequent membrane disruption implicated in the viral pathogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, J" uniqKey="Peiris J">J. Peiris</name></author><author><name sortKey="Lai, S" uniqKey="Lai S">S. Lai</name></author><author><name sortKey="Poon, L" uniqKey="Poon L">L. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yam, L" uniqKey="Yam L">L. Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. 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Straume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, P D" uniqKey="Ross P">P.D. Ross</name></author><author><name sortKey="Subramanian, S" uniqKey="Subramanian S">S. Subramanian</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bhattacharyya, Dipita" sort="Bhattacharyya, Dipita" uniqKey="Bhattacharyya D" first="Dipita" last="Bhattacharyya">Dipita Bhattacharyya</name><name sortKey="Bhunia, Anirban" sort="Bhunia, Anirban" uniqKey="Bhunia A" first="Anirban" last="Bhunia">Anirban Bhunia</name><name sortKey="Ghosh, Anirban" sort="Ghosh, Anirban" uniqKey="Ghosh A" first="Anirban" last="Ghosh">Anirban Ghosh</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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