A novel mechanism for immune regulation after human lung transplantation
Identifieur interne : 000D70 ( Main/Exploration ); précédent : 000D69; suivant : 000D71A novel mechanism for immune regulation after human lung transplantation
Auteurs : Thalachallour Mohanakumar ; Monal Sharma ; Sandhya Bansal ; Ranjithkumar Ravichandran ; Michael A. Smith ; Ross M. BremnerSource :
- The Journal of Thoracic and Cardiovascular Surgery [ 0022-5223 ] ; 2019.
Abstract
Lung transplantation is therapeutic for end-stage lung disease, but survival is limited due to bronchiolitis obliterans syndrome and restrictive chronic lung allograft dysfunction. We sought a common denominator in lung transplant recipients, analyzing risk factors that trigger immune responses that lead to bronchiolitis obliterans syndrome.
We collected blood from patients who underwent lung transplant at our institution. Exosomes were isolated from the sera of recipients with risk factors for chronic rejection and from stable recipients. Exosomes were analyzed with western blot, using antibodies to lung self-antigens K alpha 1 tubulin and collagen-V, costimulatory molecules (costimulatory molecule 80, costimulatory molecule 86), transcription factors (nuclear factor kappa-light-chain-enhancer of activated B cells, hypoxia-inducible factor 1α, Class II Major Histocompatibility Complex Transactivator), and 20S proteasome.
Of the 90 patients included, we identified 5 with grade 3 primary graft dysfunction, 5 without, 15 with respiratory viral infection, 10 with acute rejection, 10 with donor-specific antibodies (DSA), 5 without DSA, and 10 who were stable for exosome isolation. Recipients with grade 3 primary graft dysfunction, respiratory viral infection, acute rejection, and DSA had exosomes containing self-antigens; exosomes from stable recipients did not. Exosomes from recipients with grade 3 primary graft dysfunction, acute rejection, and DSA also demonstrated costimulatory molecule 80, costimulatory molecule 86, major histocompatibility complex class II, transcription factor, and 20S proteasome.
Transplanted lungs with grade 3 primary graft dysfunction, symptomatic respiratory viral infection, acute rejection, and immune responses induce exosomes that contain self-antigens, costimulatory molecules, major histocompatibility complex class II, transcription factors, and 20S proteasome. Release of circulating exosomes post-transplant from the aforementioned stress-inducing insults augment immunity and may play an important role in the pathogenesis of bronchiolitis obliterans syndrome.
Url:
DOI: 10.1016/j.jtcvs.2018.12.105
PubMed: 31288367
PubMed Central: 6625531
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000941
- to stream Pmc, to step Curation: 000941
- to stream Pmc, to step Checkpoint: 000279
- to stream Ncbi, to step Merge: 000878
- to stream Ncbi, to step Curation: 000878
- to stream Ncbi, to step Checkpoint: 000878
- to stream Main, to step Merge: 000D72
- to stream Main, to step Curation: 000D70
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A novel mechanism for immune regulation after human lung transplantation</title><author><name sortKey="Mohanakumar, Thalachallour" sort="Mohanakumar, Thalachallour" uniqKey="Mohanakumar T" first="Thalachallour" last="Mohanakumar">Thalachallour Mohanakumar</name></author><author><name sortKey="Sharma, Monal" sort="Sharma, Monal" uniqKey="Sharma M" first="Monal" last="Sharma">Monal Sharma</name></author><author><name sortKey="Bansal, Sandhya" sort="Bansal, Sandhya" uniqKey="Bansal S" first="Sandhya" last="Bansal">Sandhya Bansal</name></author><author><name sortKey="Ravichandran, Ranjithkumar" sort="Ravichandran, Ranjithkumar" uniqKey="Ravichandran R" first="Ranjithkumar" last="Ravichandran">Ranjithkumar Ravichandran</name></author><author><name sortKey="Smith, Michael A" sort="Smith, Michael A" uniqKey="Smith M" first="Michael A." last="Smith">Michael A. Smith</name></author><author><name sortKey="Bremner, Ross M" sort="Bremner, Ross M" uniqKey="Bremner R" first="Ross M." last="Bremner">Ross M. Bremner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31288367</idno><idno type="pmc">6625531</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625531</idno><idno type="RBID">PMC:6625531</idno><idno type="doi">10.1016/j.jtcvs.2018.12.105</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000941</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000941</idno><idno type="wicri:Area/Pmc/Curation">000941</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000941</idno><idno type="wicri:Area/Pmc/Checkpoint">000279</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000279</idno><idno type="wicri:Area/Ncbi/Merge">000878</idno><idno type="wicri:Area/Ncbi/Curation">000878</idno><idno type="wicri:Area/Ncbi/Checkpoint">000878</idno><idno type="wicri:doubleKey">0022-5223:2019:Mohanakumar T:a:novel:mechanism</idno><idno type="wicri:Area/Main/Merge">000D72</idno><idno type="wicri:Area/Main/Curation">000D70</idno><idno type="wicri:Area/Main/Exploration">000D70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A novel mechanism for immune regulation after human lung transplantation</title><author><name sortKey="Mohanakumar, Thalachallour" sort="Mohanakumar, Thalachallour" uniqKey="Mohanakumar T" first="Thalachallour" last="Mohanakumar">Thalachallour Mohanakumar</name></author><author><name sortKey="Sharma, Monal" sort="Sharma, Monal" uniqKey="Sharma M" first="Monal" last="Sharma">Monal Sharma</name></author><author><name sortKey="Bansal, Sandhya" sort="Bansal, Sandhya" uniqKey="Bansal S" first="Sandhya" last="Bansal">Sandhya Bansal</name></author><author><name sortKey="Ravichandran, Ranjithkumar" sort="Ravichandran, Ranjithkumar" uniqKey="Ravichandran R" first="Ranjithkumar" last="Ravichandran">Ranjithkumar Ravichandran</name></author><author><name sortKey="Smith, Michael A" sort="Smith, Michael A" uniqKey="Smith M" first="Michael A." last="Smith">Michael A. Smith</name></author><author><name sortKey="Bremner, Ross M" sort="Bremner, Ross M" uniqKey="Bremner R" first="Ross M." last="Bremner">Ross M. Bremner</name></author></analytic><series><title level="j">The Journal of Thoracic and Cardiovascular Surgery</title><idno type="ISSN">0022-5223</idno><idno type="eISSN">1097-685X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>Lung transplantation is therapeutic for end-stage lung disease, but survival is limited due to bronchiolitis obliterans syndrome and restrictive chronic lung allograft dysfunction. We sought a common denominator in lung transplant recipients, analyzing risk factors that trigger immune responses that lead to bronchiolitis obliterans syndrome.</p></sec><sec><title>Methods</title><p>We collected blood from patients who underwent lung transplant at our institution. Exosomes were isolated from the sera of recipients with risk factors for chronic rejection and from stable recipients. Exosomes were analyzed with western blot, using antibodies to lung self-antigens K alpha 1 tubulin and collagen-V, costimulatory molecules (costimulatory molecule 80, costimulatory molecule 86), transcription factors (nuclear factor kappa-light-chain-enhancer of activated B cells, hypoxia-inducible factor 1α, Class II Major Histocompatibility Complex Transactivator), and 20S proteasome.</p></sec><sec><title>Results</title><p>Of the 90 patients included, we identified 5 with grade 3 primary graft dysfunction, 5 without, 15 with respiratory viral infection, 10 with acute rejection, 10 with donor-specific antibodies (DSA), 5 without DSA, and 10 who were stable for exosome isolation. Recipients with grade 3 primary graft dysfunction, respiratory viral infection, acute rejection, and DSA had exosomes containing self-antigens; exosomes from stable recipients did not. Exosomes from recipients with grade 3 primary graft dysfunction, acute rejection, and DSA also demonstrated costimulatory molecule 80, costimulatory molecule 86, major histocompatibility complex class II, transcription factor, and 20S proteasome.</p></sec><sec><title>Conclusions</title><p>Transplanted lungs with grade 3 primary graft dysfunction, symptomatic respiratory viral infection, acute rejection, and immune responses induce exosomes that contain self-antigens, costimulatory molecules, major histocompatibility complex class II, transcription factors, and 20S proteasome. Release of circulating exosomes post-transplant from the aforementioned stress-inducing insults augment immunity and may play an important role in the pathogenesis of bronchiolitis obliterans syndrome.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arcasoy, S M" uniqKey="Arcasoy S">S.M. Arcasoy</name></author><author><name sortKey="Kotloff, R M" uniqKey="Kotloff R">R.M. Kotloff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trulock, E P" uniqKey="Trulock E">E.P. Trulock</name></author><author><name sortKey="Edwards, L B" uniqKey="Edwards L">L.B. Edwards</name></author><author><name sortKey="Taylor, D O" uniqKey="Taylor D">D.O. Taylor</name></author><author><name sortKey="Boucek, M M" uniqKey="Boucek M">M.M. Boucek</name></author><author><name sortKey="Keck, B M" uniqKey="Keck B">B.M. Keck</name></author><author><name sortKey="Hertz, M I" uniqKey="Hertz M">M.I. Hertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Estenne, M" uniqKey="Estenne M">M. Estenne</name></author><author><name sortKey="Hertz, M I" uniqKey="Hertz M">M.I. Hertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaramillo, A" uniqKey="Jaramillo A">A. Jaramillo</name></author><author><name sortKey="Smith, M A" uniqKey="Smith M">M.A. Smith</name></author><author><name sortKey="Phelan, D" uniqKey="Phelan D">D. Phelan</name></author><author><name sortKey="Sundaresan, S" uniqKey="Sundaresan S">S. Sundaresan</name></author><author><name sortKey="Trulock, E P" uniqKey="Trulock E">E.P. Trulock</name></author><author><name sortKey="Lynch, J P" uniqKey="Lynch J">J.P. Lynch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hachem, R R" uniqKey="Hachem R">R.R. Hachem</name></author><author><name sortKey="Yusen, R D" uniqKey="Yusen R">R.D. Yusen</name></author><author><name sortKey="Meyers, B F" uniqKey="Meyers B">B.F. Meyers</name></author><author><name sortKey="Aloush, A A" uniqKey="Aloush A">A.A. Aloush</name></author><author><name sortKey="Mohanakumar, T" uniqKey="Mohanakumar T">T. Mohanakumar</name></author><author><name sortKey="Patterson, G A" uniqKey="Patterson G">G.A. Patterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bharat, A" uniqKey="Bharat A">A. Bharat</name></author><author><name sortKey="Saini, D" uniqKey="Saini D">D. Saini</name></author><author><name sortKey="Steward, N" uniqKey="Steward N">N. Steward</name></author><author><name sortKey="Hachem, R" uniqKey="Hachem R">R. Hachem</name></author><author><name sortKey="Trulock, E P" uniqKey="Trulock E">E.P. Trulock</name></author><author><name sortKey="Patterson, G A" uniqKey="Patterson G">G.A. Patterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bharat, A" uniqKey="Bharat A">A. Bharat</name></author><author><name sortKey="Kuo, E" uniqKey="Kuo E">E. Kuo</name></author><author><name sortKey="Saini, D" uniqKey="Saini D">D. Saini</name></author><author><name sortKey="Steward, N" uniqKey="Steward N">N. Steward</name></author><author><name sortKey="Hachem, R" uniqKey="Hachem R">R. Hachem</name></author><author><name sortKey="Trulock, E P" uniqKey="Trulock E">E.P. Trulock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almaghrabi, R S" uniqKey="Almaghrabi R">R.S. Almaghrabi</name></author><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, C E" uniqKey="Fisher C">C.E. Fisher</name></author><author><name sortKey="Mohanakumar, T" uniqKey="Mohanakumar T">T. Mohanakumar</name></author><author><name sortKey="Limaye, A P" uniqKey="Limaye A">A.P. Limaye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aguilar, P R" uniqKey="Aguilar P">P.R. Aguilar</name></author><author><name sortKey="Carpenter, D" uniqKey="Carpenter D">D. Carpenter</name></author><author><name sortKey="Ritter, J" uniqKey="Ritter J">J. Ritter</name></author><author><name sortKey="Yusen, R D" uniqKey="Yusen R">R.D. Yusen</name></author><author><name sortKey="Witt, C A" uniqKey="Witt C">C.A. Witt</name></author><author><name sortKey="Byers, D E" uniqKey="Byers D">D.E. Byers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z. Xu</name></author><author><name sortKey="Yang, W" uniqKey="Yang W">W. Yang</name></author><author><name sortKey="Steward, N" uniqKey="Steward N">N. Steward</name></author><author><name sortKey="Sweet, S C" uniqKey="Sweet S">S.C. Sweet</name></author><author><name sortKey="Danziger Isakov, L" uniqKey="Danziger Isakov L">L. Danziger-Isakov</name></author><author><name sortKey="Heeger, P S" uniqKey="Heeger P">P.S. Heeger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simpson, R J" uniqKey="Simpson R">R.J. Simpson</name></author><author><name sortKey="Jensen, S S" uniqKey="Jensen S">S.S. Jensen</name></author><author><name sortKey="Lim, J W E" uniqKey="Lim J">J.W.E. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raimondo, F" uniqKey="Raimondo F">F. Raimondo</name></author><author><name sortKey="Morosi, L" uniqKey="Morosi L">L. Morosi</name></author><author><name sortKey="Chinello, C" uniqKey="Chinello C">C. Chinello</name></author><author><name sortKey="Magni, F" uniqKey="Magni F">F. Magni</name></author><author><name sortKey="Pitto, M" uniqKey="Pitto M">M. Pitto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melo, S A" uniqKey="Melo S">S.A. Melo</name></author><author><name sortKey="Sugimoto, H" uniqKey="Sugimoto H">H. Sugimoto</name></author><author><name sortKey="O Connell, J T" uniqKey="O Connell J">J.T. O'Connell</name></author><author><name sortKey="Kato, N" uniqKey="Kato N">N. Kato</name></author><author><name sortKey="Villanueva, A" uniqKey="Villanueva A">A. Villanueva</name></author><author><name sortKey="Vidal, A" uniqKey="Vidal A">A. Vidal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gregson, A L" uniqKey="Gregson A">A.L. Gregson</name></author><author><name sortKey="Hoji, A" uniqKey="Hoji A">A. Hoji</name></author><author><name sortKey="Injean, P" uniqKey="Injean P">P. Injean</name></author><author><name sortKey="Poynter, S T" uniqKey="Poynter S">S.T. Poynter</name></author><author><name sortKey="Briones, C" uniqKey="Briones C">C. Briones</name></author><author><name sortKey="Palchevskiy, V" uniqKey="Palchevskiy V">V. Palchevskiy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunasekaran, M" uniqKey="Gunasekaran M">M. Gunasekaran</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z. Xu</name></author><author><name sortKey="Nayak, D K" uniqKey="Nayak D">D.K. Nayak</name></author><author><name sortKey="Sharma, M" uniqKey="Sharma M">M. Sharma</name></author><author><name sortKey="Hachem, R" uniqKey="Hachem R">R. Hachem</name></author><author><name sortKey="Walia, R" uniqKey="Walia R">R. Walia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaramillo, A" uniqKey="Jaramillo A">A. Jaramillo</name></author><author><name sortKey="Smith, C R" uniqKey="Smith C">C.R. Smith</name></author><author><name sortKey="Maruyama, T" uniqKey="Maruyama T">T. Maruyama</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Patterson, G A" uniqKey="Patterson G">G.A. Patterson</name></author><author><name sortKey="Mohanakumar, T" uniqKey="Mohanakumar T">T. Mohanakumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Logozzi, M" uniqKey="Logozzi M">M. Logozzi</name></author><author><name sortKey="Angelini, D F" uniqKey="Angelini D">D.F. Angelini</name></author><author><name sortKey="Iessi, E" uniqKey="Iessi E">E. Iessi</name></author><author><name sortKey="Mizzoni, D" uniqKey="Mizzoni D">D. Mizzoni</name></author><author><name sortKey="Diraimo, R" uniqKey="Diraimo R">R. DiRaimo</name></author><author><name sortKey="Federic, C" uniqKey="Federic C">C. Federic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weigt, S S" uniqKey="Weigt S">S.S. Weigt</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Palchevsky, V" uniqKey="Palchevsky V">V. Palchevsky</name></author><author><name sortKey="Gregson, A L" uniqKey="Gregson A">A.L. Gregson</name></author><author><name sortKey="Patel, N" uniqKey="Patel N">N. Patel</name></author><author><name sortKey="Derhovanessian, A" uniqKey="Derhovanessian A">A. DerHovanessian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morelli, A E" uniqKey="Morelli A">A.E. Morelli</name></author><author><name sortKey="Bracamonte Baran, W" uniqKey="Bracamonte Baran W">W. Bracamonte-Baran</name></author><author><name sortKey="Burlingham, W J" uniqKey="Burlingham W">W.J. Burlingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Rojas Canales, D M" uniqKey="Rojas Canales D">D.M. Rojas-Canales</name></author><author><name sortKey="Divito, S J" uniqKey="Divito S">S.J. Divito</name></author><author><name sortKey="Shufesky, W J" uniqKey="Shufesky W">W.J. Shufesky</name></author><author><name sortKey="Stolz, D B" uniqKey="Stolz D">D.B. Stolz</name></author><author><name sortKey="Erdos, G" uniqKey="Erdos G">G. Erdos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunasekaran, M" uniqKey="Gunasekaran M">M. Gunasekaran</name></author><author><name sortKey="Sharma, M" uniqKey="Sharma M">M. Sharma</name></author><author><name sortKey="Hachem, R" uniqKey="Hachem R">R. Hachem</name></author><author><name sortKey="Bremner, R" uniqKey="Bremner R">R. Bremner</name></author><author><name sortKey="Smith, M A" uniqKey="Smith M">M.A. Smith</name></author><author><name sortKey="Mohanakumar, T" uniqKey="Mohanakumar T">T. Mohanakumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, M" uniqKey="Sharma M">M. Sharma</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Perincheri, S" uniqKey="Perincheri S">S. Perincheri</name></author><author><name sortKey="Gunasekaran, M" uniqKey="Gunasekaran M">M. Gunasekaran</name></author><author><name sortKey="Mohanakumar, T" uniqKey="Mohanakumar T">T. Mohanakumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dieude, M" uniqKey="Dieude M">M. Dieude</name></author><author><name sortKey="Bell, C" uniqKey="Bell C">C. Bell</name></author><author><name sortKey="Turgeon, J" uniqKey="Turgeon J">J. Turgeon</name></author><author><name sortKey="Beillevaire, D" uniqKey="Beillevaire D">D. Beillevaire</name></author><author><name sortKey="Pomerleau, L" uniqKey="Pomerleau L">L. Pomerleau</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tower, C M" uniqKey="Tower C">C.M. Tower</name></author><author><name sortKey="Reyes, M" uniqKey="Reyes M">M. Reyes</name></author><author><name sortKey="Nelson, K" uniqKey="Nelson K">K. Nelson</name></author><author><name sortKey="Leca, N" uniqKey="Leca N">N. Leca</name></author><author><name sortKey="Kieran, N" uniqKey="Kieran N">N. Kieran</name></author><author><name sortKey="Muczynski, K" uniqKey="Muczynski K">K. Muczynski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bansal, Sandhya" sort="Bansal, Sandhya" uniqKey="Bansal S" first="Sandhya" last="Bansal">Sandhya Bansal</name><name sortKey="Bremner, Ross M" sort="Bremner, Ross M" uniqKey="Bremner R" first="Ross M." last="Bremner">Ross M. Bremner</name><name sortKey="Mohanakumar, Thalachallour" sort="Mohanakumar, Thalachallour" uniqKey="Mohanakumar T" first="Thalachallour" last="Mohanakumar">Thalachallour Mohanakumar</name><name sortKey="Ravichandran, Ranjithkumar" sort="Ravichandran, Ranjithkumar" uniqKey="Ravichandran R" first="Ranjithkumar" last="Ravichandran">Ranjithkumar Ravichandran</name><name sortKey="Sharma, Monal" sort="Sharma, Monal" uniqKey="Sharma M" first="Monal" last="Sharma">Monal Sharma</name><name sortKey="Smith, Michael A" sort="Smith, Michael A" uniqKey="Smith M" first="Michael A." last="Smith">Michael A. Smith</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D70 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D70 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6625531
|texte= A novel mechanism for immune regulation after human lung transplantation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31288367" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |