TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib.
Identifieur interne : 000310 ( Main/Exploration ); précédent : 000309; suivant : 000311TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib.
Auteurs : Dandan Wu [République populaire de Chine] ; Xuexian O. Yang [États-Unis]Source :
- Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [ 1995-9133 ] ; 2020.
Abstract
COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing mortality of patients with TH17 type immune profiles.
DOI: 10.1016/j.jmii.2020.03.005
PubMed: 32205092
Affiliations:
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Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA. Electronic address: xyang@salud.unm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, 87131</wicri:regionArea><wicri:noRegion>87131</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi</title><idno type="eISSN">1995-9133</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing mortality of patients with TH17 type immune profiles.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Dandan" sort="Wu, Dandan" uniqKey="Wu D" first="Dandan" last="Wu">Dandan Wu</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Yang, Xuexian O" sort="Yang, Xuexian O" uniqKey="Yang X" first="Xuexian O" last="Yang">Xuexian O. Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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