Expanding roles for CD4+ T cells in immunity to viruses
Identifieur interne : 001318 ( Main/Curation ); précédent : 001317; suivant : 001319Expanding roles for CD4+ T cells in immunity to viruses
Auteurs : Susan L. Swain ; K. Kai Mckinstry ; Tara M. StruttSource :
- Nature reviews. Immunology [ 1474-1733 ] ; 2012.
Abstract
Viral pathogens often generate strong CD4+ T cell responses that are best known for their ability to help B cell and CD8+ T cell responses. However, recent studies reveal additional roles for CD4+ T cells, some of which are independent of other lymphocytes, and indicate that memory cells are more effective in most functions than naïve CD4 T cells. Here, we review the full spectrum of antiviral functions of CD4+ T cells, including their helper activities, innate immune induction, and direct anti-viral roles, and suggest how these functions are integrated to provide highly protective responses against viral pathogens.
Url:
DOI: 10.1038/nri3152
PubMed: 22266691
PubMed Central: 3764486
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PMC:3764486Le document en format XML
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