LifeGene—a large prospective population-based study of global relevance
Identifieur interne : 000698 ( Istex/Curation ); précédent : 000697; suivant : 000699LifeGene—a large prospective population-based study of global relevance
Auteurs : Catarina Almqvist [Suède] ; Hans-Olov Adami [Suède, États-Unis] ; Paul W. Franks [Suède] ; Leif Groop [Suède] ; Erik Ingelsson [Suède] ; Juha Kere [Suède] ; Lauren Lissner [Suède] ; Jan-Eric Litton [Suède] ; Markus Maeurer [Suède] ; Karl Michaëlsson [Suède] ; Juni Palmgren [Suède] ; Göran Pershagen [Suède] ; Alexander Ploner [Suède] ; Patrick F. Sullivan [États-Unis] ; Gunnel Tybring [Suède] ; Nancy L. Pedersen [Suède]Source :
- European Journal of Epidemiology [ 0393-2990 ] ; 2011-01-01.
Descripteurs français
- Wicri :
- topic : épidémiologie.
English descriptors
Abstract
Abstract: Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18–45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants’ age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.
Url:
DOI: 10.1007/s10654-010-9521-x
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Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Swedish Institute for Infectious Disease Control, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Swedish Institute for Infectious Disease Control, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Palmgren, Juni" sort="Palmgren, Juni" uniqKey="Palmgren J" first="Juni" last="Palmgren">Juni Palmgren</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, 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Franks</name><affiliation wicri:level="1"><mods:affiliation>Department of Public Health & Clinical Medicine, Section for Medicine, Umeå University Hospital Sweden, Umeå, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health & Clinical Medicine, Section for Medicine, Umeå University Hospital Sweden, Umeå</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Lund University, Malmo, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Lund University, Malmo</wicri:regionArea></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Sciences, Diabetes and Endocrinology Unit, Lund University, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology Unit, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><affiliation wicri:level="1"><mods:affiliation>Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge</wicri:regionArea></affiliation></author><author><name sortKey="Lissner, Lauren" sort="Lissner, Lauren" uniqKey="Lissner L" first="Lauren" last="Lissner">Lauren Lissner</name><affiliation wicri:level="1"><mods:affiliation>Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Litton, Jan Eric" sort="Litton, Jan Eric" uniqKey="Litton J" first="Jan-Eric" last="Litton">Jan-Eric Litton</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Swedish Institute for Infectious Disease Control, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Swedish Institute for Infectious Disease Control, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Palmgren, Juni" sort="Palmgren, Juni" uniqKey="Palmgren J" first="Juni" last="Palmgren">Juni Palmgren</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Mathematical Statistics, Stockholm University, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Mathematical Statistics, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Pershagen, Goran" sort="Pershagen, Goran" uniqKey="Pershagen G" first="Göran" last="Pershagen">Göran Pershagen</name><affiliation wicri:level="1"><mods:affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Ploner, Alexander" sort="Ploner, Alexander" uniqKey="Ploner A" first="Alexander" last="Ploner">Alexander Ploner</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Sullivan, Patrick F" sort="Sullivan, Patrick F" uniqKey="Sullivan P" first="Patrick F." last="Sullivan">Patrick F. Sullivan</name><affiliation wicri:level="1"><mods:affiliation>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Tybring, Gunnel" sort="Tybring, Gunnel" uniqKey="Tybring G" first="Gunnel" last="Tybring">Gunnel Tybring</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: nancy.pedersen@ki.se</mods:affiliation><country wicri:rule="url">Suède</country></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Epidemiology</title><title level="j" type="abbrev">Eur J Epidemiol</title><idno type="ISSN">0393-2990</idno><idno type="eISSN">1573-7284</idno><imprint><publisher>Springer Netherlands</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2011-01-01">2011-01-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="77">77</biblScope></imprint><idno type="ISSN">0393-2990</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0393-2990</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biobank</term><term>Cohort study</term><term>Epidemiology</term><term>Population genetics</term><term>Prospective study</term><term>Questionnaires</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>épidémiologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18–45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants’ age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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