Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM
Identifieur interne : 000041 ( Istex/Curation ); précédent : 000040; suivant : 000042Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM
Auteurs : R. Dörries [Allemagne] ; R. Watanabe [Allemagne] ; H. Wege [Allemagne] ; V. Ter Meulen [Allemagne]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1987.
English descriptors
- Teeft :
- Acta neuropathol, Active demyelination, Animal model, Antibodies intrathecally, Antibody, Antibody bands, Antibody response, Antibody synthesis, Antibody titres, Antigen expression, Apparent disease, Basic myelin protein, Black arrows, Brain lesions, Brain tissue, Broad pattern, Brown norway, Cerebrospinal fluid, Clonal distribution, Corona virus, Coronavirus, Dako patts, Demyelinating, Demyelinating diseases, Demyelinating encephalomyelitis, Demyelination, Diseased lewis rats, Disproportional increase, Encephalomyelitis, Enzyme immunoassay, Filter area, Glia cells, Immune reaction, Immune response, Immunoglobulin, Infectious process, Inflammatory changes, Inflammatory reactions, Intracerebral spread, Intrathecal, Intrathecal synthesis, Isoelectric distribution, Lesion, Lewis rats, Local production, Meulen, Mild demyelinating encephalomyelitis, Mumps meningitis, Murine, Murine coronavirus, Oligoclonal, Pathogenetic role, Peplomer protein, Perivascular cuffings, Permeability, Persistent infection, Plasma cells, Protein profile, Rat, Serum specimens, Small proteins, Specific antibody indices, Spinal cord, Subacute demyelinating encephalomyelitis, Total immunoglobulin, Varicella zoster meningoencephalitis, Viral, Viral antibodies, Viral antigen, Viral antigens, Viral infections, Virus infection, Virus infections, Virus inoculation, Watanabe, Wege.
Abstract
Abstract: Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.
Url:
DOI: 10.1016/0165-5728(87)90017-8
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<term>Active demyelination</term>
<term>Animal model</term>
<term>Antibodies intrathecally</term>
<term>Antibody</term>
<term>Antibody bands</term>
<term>Antibody response</term>
<term>Antibody synthesis</term>
<term>Antibody titres</term>
<term>Antigen expression</term>
<term>Apparent disease</term>
<term>Basic myelin protein</term>
<term>Black arrows</term>
<term>Brain lesions</term>
<term>Brain tissue</term>
<term>Broad pattern</term>
<term>Brown norway</term>
<term>Cerebrospinal fluid</term>
<term>Clonal distribution</term>
<term>Corona virus</term>
<term>Coronavirus</term>
<term>Dako patts</term>
<term>Demyelinating</term>
<term>Demyelinating diseases</term>
<term>Demyelinating encephalomyelitis</term>
<term>Demyelination</term>
<term>Diseased lewis rats</term>
<term>Disproportional increase</term>
<term>Encephalomyelitis</term>
<term>Enzyme immunoassay</term>
<term>Filter area</term>
<term>Glia cells</term>
<term>Immune reaction</term>
<term>Immune response</term>
<term>Immunoglobulin</term>
<term>Infectious process</term>
<term>Inflammatory changes</term>
<term>Inflammatory reactions</term>
<term>Intracerebral spread</term>
<term>Intrathecal</term>
<term>Intrathecal synthesis</term>
<term>Isoelectric distribution</term>
<term>Lesion</term>
<term>Lewis rats</term>
<term>Local production</term>
<term>Meulen</term>
<term>Mild demyelinating encephalomyelitis</term>
<term>Mumps meningitis</term>
<term>Murine</term>
<term>Murine coronavirus</term>
<term>Oligoclonal</term>
<term>Pathogenetic role</term>
<term>Peplomer protein</term>
<term>Perivascular cuffings</term>
<term>Permeability</term>
<term>Persistent infection</term>
<term>Plasma cells</term>
<term>Protein profile</term>
<term>Rat</term>
<term>Serum specimens</term>
<term>Small proteins</term>
<term>Specific antibody indices</term>
<term>Spinal cord</term>
<term>Subacute demyelinating encephalomyelitis</term>
<term>Total immunoglobulin</term>
<term>Varicella zoster meningoencephalitis</term>
<term>Viral</term>
<term>Viral antibodies</term>
<term>Viral antigen</term>
<term>Viral antigens</term>
<term>Viral infections</term>
<term>Virus infection</term>
<term>Virus infections</term>
<term>Virus inoculation</term>
<term>Watanabe</term>
<term>Wege</term>
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<front><div type="abstract" xml:lang="en">Abstract: Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.</div>
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