Duration of challenge immunity to coronavirus JHM in mice.
Identifieur interne : 000745 ( PubMed/Corpus ); précédent : 000744; suivant : 000746Duration of challenge immunity to coronavirus JHM in mice.
Auteurs : S W Barthold ; A L SmithSource :
- Archives of virology [ 0304-8608 ] ; 1989.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (analysis), Immunity, Intestines (immunology), Intestines (pathology), Liver (microbiology), Liver (pathology), Lymphoid Tissue (pathology), Mice, Mice, Inbred BALB C, Murine hepatitis virus (immunology), Murine hepatitis virus (isolation & purification), Nasal Bone (microbiology), Random Allocation, Time Factors.
- MESH :
- chemical , analysis : Antibodies, Viral.
- immunology : Intestines, Murine hepatitis virus.
- isolation & purification : Murine hepatitis virus.
- microbiology : Liver, Nasal Bone.
- pathology : Intestines, Liver, Lymphoid Tissue.
- Animals, Immunity, Mice, Mice, Inbred BALB C, Random Allocation, Time Factors.
Abstract
The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalence of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.
DOI: 10.1007/bf01317914
PubMed: 2554852
Links to Exploration step
pubmed:2554852Le document en format XML
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Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalence of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2554852</PMID><DateCompleted><Year>1989</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-8608</ISSN><JournalIssue CitedMedium="Print"><Volume>107</Volume><Issue>3-4</Issue><PubDate><Year>1989</Year></PubDate></JournalIssue><Title>Archives of virology</Title><ISOAbbreviation>Arch. Virol.</ISOAbbreviation></Journal><ArticleTitle>Duration of challenge immunity to coronavirus JHM in mice.</ArticleTitle><Pagination><MedlinePgn>171-7</MedlinePgn></Pagination><Abstract><AbstractText>The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalence of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. 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