Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients.
Identifieur interne : 000663 ( PubMed/Corpus ); précédent : 000662; suivant : 000664Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients.
Auteurs : Ji Hyun Lee ; Ja-Hyun Jang ; Soo Hyun Lee ; Yae-Jean Kim ; Keon Hee Yoo ; Ki-Woong Sung ; Nam Yong Lee ; Chang-Seok Ki ; Hong Heo KooSource :
- Clinical transplantation [ 1399-0012 ]
English descriptors
- KwdEn :
- Adolescent, Adult, Child, Child, Preschool, Female, Follow-Up Studies, Hematologic Neoplasms (mortality), Hematologic Neoplasms (therapy), Hematopoietic Stem Cell Transplantation (adverse effects), Humans, Incidence, Infant, Infant, Newborn, Male, Picornaviridae Infections (epidemiology), Picornaviridae Infections (etiology), Picornaviridae Infections (mortality), Prognosis, Republic of Korea (epidemiology), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (etiology), Respiratory Syncytial Virus Infections (mortality), Respiratory Syncytial Viruses (pathogenicity), Retrospective Studies, Rhinovirus (pathogenicity), Survival Rate, Tertiary Care Centers, Young Adult.
- MESH :
- geographic , epidemiology : Republic of Korea.
- adverse effects : Hematopoietic Stem Cell Transplantation.
- epidemiology : Picornaviridae Infections, Respiratory Syncytial Virus Infections.
- etiology : Picornaviridae Infections, Respiratory Syncytial Virus Infections.
- mortality : Hematologic Neoplasms, Picornaviridae Infections, Respiratory Syncytial Virus Infections.
- pathogenicity : Respiratory Syncytial Viruses, Rhinovirus.
- therapy : Hematologic Neoplasms.
- Adolescent, Adult, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Incidence, Infant, Infant, Newborn, Male, Prognosis, Retrospective Studies, Survival Rate, Tertiary Care Centers, Young Adult.
Abstract
Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.
DOI: 10.1111/j.1399-0012.2012.01607.x
PubMed: 22385011
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pubmed:22385011Le document en format XML
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first="Keon Hee" last="Yoo">Keon Hee Yoo</name></author><author><name sortKey="Sung, Ki Woong" sort="Sung, Ki Woong" uniqKey="Sung K" first="Ki-Woong" last="Sung">Ki-Woong Sung</name></author><author><name sortKey="Lee, Nam Yong" sort="Lee, Nam Yong" uniqKey="Lee N" first="Nam Yong" last="Lee">Nam Yong Lee</name></author><author><name sortKey="Ki, Chang Seok" sort="Ki, Chang Seok" uniqKey="Ki C" first="Chang-Seok" last="Ki">Chang-Seok Ki</name></author><author><name sortKey="Koo, Hong Heo" sort="Koo, Hong Heo" uniqKey="Koo H" first="Hong Heo" last="Koo">Hong Heo Koo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2012 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:22385011</idno><idno type="pmid">22385011</idno><idno type="doi">10.1111/j.1399-0012.2012.01607.x</idno><idno type="wicri:Area/PubMed/Corpus">000663</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000663</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients.</title><author><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name><affiliation><nlm:affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jang, Ja Hyun" sort="Jang, Ja Hyun" uniqKey="Jang J" first="Ja-Hyun" last="Jang">Ja-Hyun Jang</name></author><author><name sortKey="Lee, Soo Hyun" sort="Lee, Soo Hyun" uniqKey="Lee S" first="Soo Hyun" last="Lee">Soo Hyun Lee</name></author><author><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name></author><author><name sortKey="Yoo, Keon Hee" sort="Yoo, Keon Hee" uniqKey="Yoo K" first="Keon Hee" last="Yoo">Keon Hee Yoo</name></author><author><name sortKey="Sung, Ki Woong" sort="Sung, Ki Woong" uniqKey="Sung K" first="Ki-Woong" last="Sung">Ki-Woong Sung</name></author><author><name sortKey="Lee, Nam Yong" sort="Lee, Nam Yong" uniqKey="Lee N" first="Nam Yong" last="Lee">Nam Yong Lee</name></author><author><name sortKey="Ki, Chang Seok" sort="Ki, Chang Seok" uniqKey="Ki C" first="Chang-Seok" last="Ki">Chang-Seok Ki</name></author><author><name sortKey="Koo, Hong Heo" sort="Koo, Hong Heo" uniqKey="Koo H" first="Hong Heo" last="Koo">Hong Heo Koo</name></author></analytic><series><title level="j">Clinical transplantation</title><idno type="eISSN">1399-0012</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Hematologic Neoplasms (mortality)</term><term>Hematologic Neoplasms (therapy)</term><term>Hematopoietic Stem Cell Transplantation (adverse effects)</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Picornaviridae Infections (epidemiology)</term><term>Picornaviridae Infections (etiology)</term><term>Picornaviridae Infections (mortality)</term><term>Prognosis</term><term>Republic of Korea (epidemiology)</term><term>Respiratory Syncytial Virus Infections (epidemiology)</term><term>Respiratory Syncytial Virus Infections (etiology)</term><term>Respiratory Syncytial Virus Infections (mortality)</term><term>Respiratory Syncytial Viruses (pathogenicity)</term><term>Retrospective Studies</term><term>Rhinovirus (pathogenicity)</term><term>Survival Rate</term><term>Tertiary Care Centers</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Republic of Korea</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Picornaviridae Infections</term><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Picornaviridae Infections</term><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Hematologic Neoplasms</term><term>Picornaviridae Infections</term><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Respiratory Syncytial Viruses</term><term>Rhinovirus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hematologic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Prognosis</term><term>Retrospective Studies</term><term>Survival Rate</term><term>Tertiary Care Centers</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22385011</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>28</Day></DateCompleted><DateRevised><Year>2012</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1399-0012</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>5</Issue><PubDate><MedlineDate>2012 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Clinical transplantation</Title><ISOAbbreviation>Clin Transplant</ISOAbbreviation></Journal><ArticleTitle>Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients.</ArticleTitle><Pagination><MedlinePgn>736-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1399-0012.2012.01607.x</ELocationID><Abstract><AbstractText>Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</AbstractText><CopyrightInformation>© 2012 John Wiley & Sons A/S.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ji Hyun</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jang</LastName><ForeName>Ja-Hyun</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Soo Hyun</ForeName><Initials>SH</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yae-Jean</ForeName><Initials>YJ</Initials></Author><Author ValidYN="Y"><LastName>Yoo</LastName><ForeName>Keon Hee</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Sung</LastName><ForeName>Ki-Woong</ForeName><Initials>KW</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Nam Yong</ForeName><Initials>NY</Initials></Author><Author ValidYN="Y"><LastName>Ki</LastName><ForeName>Chang-Seok</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Koo</LastName><ForeName>Hong Heo</ForeName><Initials>HH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Clin Transplant</MedlineTA><NlmUniqueID>8710240</NlmUniqueID><ISSNLinking>0902-0063</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019337" MajorTopicYN="N">Hematologic Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018380" MajorTopicYN="N">Hematopoietic Stem Cell Transplantation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010850" MajorTopicYN="N">Picornaviridae Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056910" MajorTopicYN="N" Type="Geographic">Republic of Korea</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012136" MajorTopicYN="N">Respiratory Syncytial Viruses</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012229" MajorTopicYN="N">Rhinovirus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062606" MajorTopicYN="N">Tertiary Care Centers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>12</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22385011</ArticleId><ArticleId IdType="doi">10.1111/j.1399-0012.2012.01607.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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