Fatal disseminated toxoplasmosis in an immunocompetent cat.
Identifieur interne : 000655 ( PubMed/Corpus ); précédent : 000654; suivant : 000656Fatal disseminated toxoplasmosis in an immunocompetent cat.
Auteurs : Susanna S. Nagel ; June H. Williams ; Johannes P. SchoemanSource :
- Journal of the South African Veterinary Association [ 2224-9435 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- immunology : Cat Diseases, Toxoplasmosis, Animal.
- parasitology : Cat Diseases, Toxoplasmosis, Animal.
- pathology : Cat Diseases, Toxoplasmosis, Animal.
- Animals, Cats, Fatal Outcome, Female, Immunocompetence.
Abstract
A 10-year-old domestic short hair cat was referred for investigation of anorexia and polydipsia of 3 days' duration. Clinically the cat was obese, pyrexic (39.8 °C), had acute abdominal pain and severe bilirubinuria. Haematology and serum biochemistry revealed severe panleukopenia, thrombocytopenia, markedly elevated alanine aminotransferase (ALT) and five-fold increased pre-prandial bile acids. Ultrasonographic evaluation of the abdomen did not identify any abnormalities. Serum tests for feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) were negative. Broad-spectrum antibiotic treatment for infectious hepatitis was to no avail; the cat deteriorated and died 72 h after admission. Necropsy revealed mild icterus and anaemia, severe multifocal hepatic necrosis, serofibrinous hydrothorax, pulmonary oedema and interstitial pneumonia. Histopathology confirmed the macroscopic findings and revealed multifocal microgranulomata in the brain and myocardium, as well as areas of necrosis in lymph nodes and multifocally in splenic red pulp. Long bone shaft marrow was hyperplastic with a predominance of leukocyte precursors and megakaryocytes and splenic red pulp showed mild extramedullary haemopoiesis. Immunohistochemical staining for Toxoplasma gondii was strongly positive, with scattered cysts and tachyzoites in the liver, lymph nodes, spleen, lungs, brain, salivary glands and intracellularly in round cells in occasional blood vessels. Immunohistochemical staining for corona virus on the same tissues was negative, ruling out feline infectious peritonitis (FIP). Polymerase chain reaction (PCR) on formalin-fixed paraffin-wax embedded tissues was positive for Toxoplasma sp., but attempts at sequencing were unsuccessful. This was the first case report of fulminant disseminated toxoplasmosis in South Africa, in which detailed histopathology in an apparently immunocompetent cat was described.
DOI: 10.4102/jsava.v84i1.299
PubMed: 23718784
Links to Exploration step
pubmed:23718784Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fatal disseminated toxoplasmosis in an immunocompetent cat.</title>
<author><name sortKey="Nagel, Susanna S" sort="Nagel, Susanna S" uniqKey="Nagel S" first="Susanna S" last="Nagel">Susanna S. Nagel</name>
<affiliation><nlm:affiliation>Department of Companion Animal Clinical Studies, University of Pretoria, Onderstepoort campus, South Africa. salome.nagel@up.ac.za</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Williams, June H" sort="Williams, June H" uniqKey="Williams J" first="June H" last="Williams">June H. Williams</name>
</author>
<author><name sortKey="Schoeman, Johannes P" sort="Schoeman, Johannes P" uniqKey="Schoeman J" first="Johannes P" last="Schoeman">Johannes P. Schoeman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23718784</idno>
<idno type="pmid">23718784</idno>
<idno type="doi">10.4102/jsava.v84i1.299</idno>
<idno type="wicri:Area/PubMed/Corpus">000655</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000655</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Fatal disseminated toxoplasmosis in an immunocompetent cat.</title>
<author><name sortKey="Nagel, Susanna S" sort="Nagel, Susanna S" uniqKey="Nagel S" first="Susanna S" last="Nagel">Susanna S. Nagel</name>
<affiliation><nlm:affiliation>Department of Companion Animal Clinical Studies, University of Pretoria, Onderstepoort campus, South Africa. salome.nagel@up.ac.za</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Williams, June H" sort="Williams, June H" uniqKey="Williams J" first="June H" last="Williams">June H. Williams</name>
</author>
<author><name sortKey="Schoeman, Johannes P" sort="Schoeman, Johannes P" uniqKey="Schoeman J" first="Johannes P" last="Schoeman">Johannes P. Schoeman</name>
</author>
</analytic>
<series><title level="j">Journal of the South African Veterinary Association</title>
<idno type="eISSN">2224-9435</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cat Diseases (immunology)</term>
<term>Cat Diseases (parasitology)</term>
<term>Cat Diseases (pathology)</term>
<term>Cats</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Immunocompetence</term>
<term>Toxoplasmosis, Animal (immunology)</term>
<term>Toxoplasmosis, Animal (parasitology)</term>
<term>Toxoplasmosis, Animal (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cat Diseases</term>
<term>Toxoplasmosis, Animal</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Cat Diseases</term>
<term>Toxoplasmosis, Animal</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cat Diseases</term>
<term>Toxoplasmosis, Animal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cats</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Immunocompetence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A 10-year-old domestic short hair cat was referred for investigation of anorexia and polydipsia of 3 days' duration. Clinically the cat was obese, pyrexic (39.8 °C), had acute abdominal pain and severe bilirubinuria. Haematology and serum biochemistry revealed severe panleukopenia, thrombocytopenia, markedly elevated alanine aminotransferase (ALT) and five-fold increased pre-prandial bile acids. Ultrasonographic evaluation of the abdomen did not identify any abnormalities. Serum tests for feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) were negative. Broad-spectrum antibiotic treatment for infectious hepatitis was to no avail; the cat deteriorated and died 72 h after admission. Necropsy revealed mild icterus and anaemia, severe multifocal hepatic necrosis, serofibrinous hydrothorax, pulmonary oedema and interstitial pneumonia. Histopathology confirmed the macroscopic findings and revealed multifocal microgranulomata in the brain and myocardium, as well as areas of necrosis in lymph nodes and multifocally in splenic red pulp. Long bone shaft marrow was hyperplastic with a predominance of leukocyte precursors and megakaryocytes and splenic red pulp showed mild extramedullary haemopoiesis. Immunohistochemical staining for Toxoplasma gondii was strongly positive, with scattered cysts and tachyzoites in the liver, lymph nodes, spleen, lungs, brain, salivary glands and intracellularly in round cells in occasional blood vessels. Immunohistochemical staining for corona virus on the same tissues was negative, ruling out feline infectious peritonitis (FIP). Polymerase chain reaction (PCR) on formalin-fixed paraffin-wax embedded tissues was positive for Toxoplasma sp., but attempts at sequencing were unsuccessful. This was the first case report of fulminant disseminated toxoplasmosis in South Africa, in which detailed histopathology in an apparently immunocompetent cat was described.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23718784</PMID>
<DateCompleted><Year>2014</Year>
<Month>02</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>10</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2224-9435</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>84</Volume>
<Issue>1</Issue>
<PubDate><Year>2013</Year>
<Month>Feb</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>Journal of the South African Veterinary Association</Title>
<ISOAbbreviation>J S Afr Vet Assoc</ISOAbbreviation>
</Journal>
<ArticleTitle>Fatal disseminated toxoplasmosis in an immunocompetent cat.</ArticleTitle>
<Pagination><MedlinePgn>E1-6</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4102/jsava.v84i1.299</ELocationID>
<Abstract><AbstractText>A 10-year-old domestic short hair cat was referred for investigation of anorexia and polydipsia of 3 days' duration. Clinically the cat was obese, pyrexic (39.8 °C), had acute abdominal pain and severe bilirubinuria. Haematology and serum biochemistry revealed severe panleukopenia, thrombocytopenia, markedly elevated alanine aminotransferase (ALT) and five-fold increased pre-prandial bile acids. Ultrasonographic evaluation of the abdomen did not identify any abnormalities. Serum tests for feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) were negative. Broad-spectrum antibiotic treatment for infectious hepatitis was to no avail; the cat deteriorated and died 72 h after admission. Necropsy revealed mild icterus and anaemia, severe multifocal hepatic necrosis, serofibrinous hydrothorax, pulmonary oedema and interstitial pneumonia. Histopathology confirmed the macroscopic findings and revealed multifocal microgranulomata in the brain and myocardium, as well as areas of necrosis in lymph nodes and multifocally in splenic red pulp. Long bone shaft marrow was hyperplastic with a predominance of leukocyte precursors and megakaryocytes and splenic red pulp showed mild extramedullary haemopoiesis. Immunohistochemical staining for Toxoplasma gondii was strongly positive, with scattered cysts and tachyzoites in the liver, lymph nodes, spleen, lungs, brain, salivary glands and intracellularly in round cells in occasional blood vessels. Immunohistochemical staining for corona virus on the same tissues was negative, ruling out feline infectious peritonitis (FIP). Polymerase chain reaction (PCR) on formalin-fixed paraffin-wax embedded tissues was positive for Toxoplasma sp., but attempts at sequencing were unsuccessful. This was the first case report of fulminant disseminated toxoplasmosis in South Africa, in which detailed histopathology in an apparently immunocompetent cat was described.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nagel</LastName>
<ForeName>Susanna S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Department of Companion Animal Clinical Studies, University of Pretoria, Onderstepoort campus, South Africa. salome.nagel@up.ac.za</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williams</LastName>
<ForeName>June H</ForeName>
<Initials>JH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schoeman</LastName>
<ForeName>Johannes P</ForeName>
<Initials>JP</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>02</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>South Africa</Country>
<MedlineTA>J S Afr Vet Assoc</MedlineTA>
<NlmUniqueID>7503122</NlmUniqueID>
<ISSNLinking>1019-9128</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002371" MajorTopicYN="N">Cat Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002415" MajorTopicYN="N">Cats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007121" MajorTopicYN="Y">Immunocompetence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014124" MajorTopicYN="N">Toxoplasmosis, Animal</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>06</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
<Month>11</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2012</Year>
<Month>10</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>5</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>5</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>2</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23718784</ArticleId>
<ArticleId IdType="doi">10.4102/jsava.v84i1.299</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000655 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000655 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:23718784 |texte= Fatal disseminated toxoplasmosis in an immunocompetent cat. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:23718784" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a CovidV1
This area was generated with Dilib version V0.6.33. |