Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV).
Identifieur interne : 000643 ( PubMed/Corpus ); précédent : 000642; suivant : 000644Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV).
Auteurs : Y M Arabi ; A. Harthi ; J. Hussein ; A. Bouchama ; S. Johani ; A H Hajeer ; B T Saeed ; A. Wahbi ; A. Saedy ; T. Aldabbagh ; R. Okaili ; M. Sadat ; H. BalkhySource :
- Infection [ 1439-0973 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Coronavirus Infections (virology), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nervous System Diseases (diagnosis), Nervous System Diseases (pathology), Nervous System Diseases (virology), Saudi Arabia.
- MESH :
- geographic : Saudi Arabia.
- diagnosis : Coronavirus Infections, Nervous System Diseases.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections, Nervous System Diseases.
- virology : Coronavirus Infections, Nervous System Diseases.
- Aged, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.
DOI: 10.1007/s15010-015-0720-y
PubMed: 25600929
Links to Exploration step
pubmed:25600929Le document en format XML
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Bouchama</name></author><author><name sortKey="Johani, S" sort="Johani, S" uniqKey="Johani S" first="S" last="Johani">S. Johani</name></author><author><name sortKey="Hajeer, A H" sort="Hajeer, A H" uniqKey="Hajeer A" first="A H" last="Hajeer">A H Hajeer</name></author><author><name sortKey="Saeed, B T" sort="Saeed, B T" uniqKey="Saeed B" first="B T" last="Saeed">B T Saeed</name></author><author><name sortKey="Wahbi, A" sort="Wahbi, A" uniqKey="Wahbi A" first="A" last="Wahbi">A. Wahbi</name></author><author><name sortKey="Saedy, A" sort="Saedy, A" uniqKey="Saedy A" first="A" last="Saedy">A. Saedy</name></author><author><name sortKey="Aldabbagh, T" sort="Aldabbagh, T" uniqKey="Aldabbagh T" first="T" last="Aldabbagh">T. Aldabbagh</name></author><author><name sortKey="Okaili, R" sort="Okaili, R" uniqKey="Okaili R" first="R" last="Okaili">R. Okaili</name></author><author><name sortKey="Sadat, M" sort="Sadat, M" uniqKey="Sadat M" first="M" last="Sadat">M. Sadat</name></author><author><name sortKey="Balkhy, H" sort="Balkhy, H" uniqKey="Balkhy H" first="H" last="Balkhy">H. Balkhy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25600929</idno><idno type="pmid">25600929</idno><idno type="doi">10.1007/s15010-015-0720-y</idno><idno type="wicri:Area/PubMed/Corpus">000643</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000643</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV).</title><author><name sortKey="Arabi, Y M" sort="Arabi, Y M" uniqKey="Arabi Y" first="Y M" last="Arabi">Y M Arabi</name><affiliation><nlm:affiliation>Intensive Care Department, MC-1425, Respiratory Services, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), P.O. Box 22490, Riyadh, 11426, Kingdom of Saudi Arabia, yaseenarabi@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Harthi, A" sort="Harthi, A" uniqKey="Harthi A" first="A" last="Harthi">A. Harthi</name></author><author><name sortKey="Hussein, J" sort="Hussein, J" uniqKey="Hussein J" first="J" last="Hussein">J. Hussein</name></author><author><name sortKey="Bouchama, A" sort="Bouchama, A" uniqKey="Bouchama A" first="A" last="Bouchama">A. Bouchama</name></author><author><name sortKey="Johani, S" sort="Johani, S" uniqKey="Johani S" first="S" last="Johani">S. Johani</name></author><author><name sortKey="Hajeer, A H" sort="Hajeer, A H" uniqKey="Hajeer A" first="A H" last="Hajeer">A H Hajeer</name></author><author><name sortKey="Saeed, B T" sort="Saeed, B T" uniqKey="Saeed B" first="B T" last="Saeed">B T Saeed</name></author><author><name sortKey="Wahbi, A" sort="Wahbi, A" uniqKey="Wahbi A" first="A" last="Wahbi">A. Wahbi</name></author><author><name sortKey="Saedy, A" sort="Saedy, A" uniqKey="Saedy A" first="A" last="Saedy">A. Saedy</name></author><author><name sortKey="Aldabbagh, T" sort="Aldabbagh, T" uniqKey="Aldabbagh T" first="T" last="Aldabbagh">T. Aldabbagh</name></author><author><name sortKey="Okaili, R" sort="Okaili, R" uniqKey="Okaili R" first="R" last="Okaili">R. Okaili</name></author><author><name sortKey="Sadat, M" sort="Sadat, M" uniqKey="Sadat M" first="M" last="Sadat">M. Sadat</name></author><author><name sortKey="Balkhy, H" sort="Balkhy, H" uniqKey="Balkhy H" first="H" last="Balkhy">H. Balkhy</name></author></analytic><series><title level="j">Infection</title><idno type="eISSN">1439-0973</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Nervous System Diseases (diagnosis)</term><term>Nervous System Diseases (pathology)</term><term>Nervous System Diseases (virology)</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25600929</PMID><DateCompleted><Year>2016</Year><Month>02</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1439-0973</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Infection</Title><ISOAbbreviation>Infection</ISOAbbreviation></Journal><ArticleTitle>Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV).</ArticleTitle><Pagination><MedlinePgn>495-501</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s15010-015-0720-y</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data was retrospectively collected from three patients admitted with MERS-CoV infection to Intensive Care unit (ICU) at King Abdulaziz Medical City, Riyadh. They were managed separately in three different wards prior to their admission to ICU.</AbstractText><AbstractText Label="FINDING" NlmCategory="RESULTS">The three patients presented with severe neurologic syndrome which included altered level of consciousness ranging from confusion to coma, ataxia, and focal motor deficit. Brain MRI revealed striking changes characterized by widespread, bilateral hyperintense lesions on T2-weighted imaging within the white matter and subcortical areas of the frontal, temporal, and parietal lobes, the basal ganglia, and corpus callosum. None of the lesions showed gadolinium enhancement.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">CNS involvement should be considered in patients with MERS-CoV and progressive neurological disease, and further elucidation of the pathophysiology of this virus is needed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arabi</LastName><ForeName>Y M</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Intensive Care Department, MC-1425, Respiratory Services, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), P.O. Box 22490, Riyadh, 11426, Kingdom of Saudi Arabia, yaseenarabi@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harthi</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Hussein</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bouchama</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Johani</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hajeer</LastName><ForeName>A H</ForeName><Initials>AH</Initials></Author><Author ValidYN="Y"><LastName>Saeed</LastName><ForeName>B T</ForeName><Initials>BT</Initials></Author><Author ValidYN="Y"><LastName>Wahbi</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Saedy</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>AlDabbagh</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Okaili</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Sadat</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Balkhy</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Infection</MedlineTA><NlmUniqueID>0365307</NlmUniqueID><ISSNLinking>0300-8126</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" 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