Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease.
Identifieur interne : 000357 ( PubMed/Corpus ); précédent : 000356; suivant : 000358Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease.
Auteurs : Wei Liu ; Zhao-Wu Tao ; Wang Lei ; Yuan Ming-Li ; Liu Kui ; Zhou Ling ; Wei Shuang ; Deng Yan ; Liu Jing ; Hui-Guo Liu ; Yang Ming ; Hu YiSource :
- Chinese medical journal [ 2542-5641 ] ; 2020.
Abstract
Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aims to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia.
DOI: 10.1097/CM9.0000000000000775
PubMed: 32118640
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease.</title><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tao, Zhao Wu" sort="Tao, Zhao Wu" uniqKey="Tao Z" first="Zhao-Wu" last="Tao">Zhao-Wu Tao</name><affiliation><nlm:affiliation>Department of Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lei, Wang" sort="Lei, Wang" uniqKey="Lei W" first="Wang" last="Lei">Wang Lei</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ming Li, Yuan" sort="Ming Li, Yuan" uniqKey="Ming Li Y" first="Yuan" last="Ming-Li">Yuan Ming-Li</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kui, Liu" sort="Kui, Liu" uniqKey="Kui L" first="Liu" last="Kui">Liu Kui</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ling, Zhou" sort="Ling, Zhou" uniqKey="Ling Z" first="Zhou" last="Ling">Zhou Ling</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shuang, Wei" sort="Shuang, Wei" uniqKey="Shuang W" first="Wei" last="Shuang">Wei Shuang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Deng" sort="Yan, Deng" uniqKey="Yan D" first="Deng" last="Yan">Deng Yan</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jing, Liu" sort="Jing, Liu" uniqKey="Jing L" first="Liu" last="Jing">Liu Jing</name><affiliation><nlm:affiliation>Department of Radiology, Wuhan Pulmonary Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Hui Guo" sort="Liu, Hui Guo" uniqKey="Liu H" first="Hui-Guo" last="Liu">Hui-Guo Liu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ming, Yang" sort="Ming, Yang" uniqKey="Ming Y" first="Yang" last="Ming">Yang Ming</name><affiliation><nlm:affiliation>The Provost's Office, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yi, Hu" sort="Yi, Hu" uniqKey="Yi H" first="Hu" last="Yi">Hu Yi</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32118640</idno><idno type="pmid">32118640</idno><idno type="doi">10.1097/CM9.0000000000000775</idno><idno type="wicri:Area/PubMed/Corpus">000357</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000357</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease.</title><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tao, Zhao Wu" sort="Tao, Zhao Wu" uniqKey="Tao Z" first="Zhao-Wu" last="Tao">Zhao-Wu Tao</name><affiliation><nlm:affiliation>Department of Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lei, Wang" sort="Lei, Wang" uniqKey="Lei W" first="Wang" last="Lei">Wang Lei</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ming Li, Yuan" sort="Ming Li, Yuan" uniqKey="Ming Li Y" first="Yuan" last="Ming-Li">Yuan Ming-Li</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kui, Liu" sort="Kui, Liu" uniqKey="Kui L" first="Liu" last="Kui">Liu Kui</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ling, Zhou" sort="Ling, Zhou" uniqKey="Ling Z" first="Zhou" last="Ling">Zhou Ling</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shuang, Wei" sort="Shuang, Wei" uniqKey="Shuang W" first="Wei" last="Shuang">Wei Shuang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Deng" sort="Yan, Deng" uniqKey="Yan D" first="Deng" last="Yan">Deng Yan</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jing, Liu" sort="Jing, Liu" uniqKey="Jing L" first="Liu" last="Jing">Liu Jing</name><affiliation><nlm:affiliation>Department of Radiology, Wuhan Pulmonary Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Hui Guo" sort="Liu, Hui Guo" uniqKey="Liu H" first="Hui-Guo" last="Liu">Hui-Guo Liu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ming, Yang" sort="Ming, Yang" uniqKey="Ming Y" first="Yang" last="Ming">Yang Ming</name><affiliation><nlm:affiliation>The Provost's Office, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yi, Hu" sort="Yi, Hu" uniqKey="Yi H" first="Hu" last="Yi">Hu Yi</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Chinese medical journal</title><idno type="eISSN">2542-5641</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aims to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32118640</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2542-5641</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Feb</Month><Day>28</Day></PubDate></JournalIssue><Title>Chinese medical journal</Title><ISOAbbreviation>Chin. Med. J.</ISOAbbreviation></Journal><ArticleTitle>Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1097/CM9.0000000000000775</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aims to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients tested positive for the COVID-19 based on nucleic acid detection were included in this study. Patients were admitted to 3 tertiary hospitals in Wuhan between December 30, 2019, and January 15, 2020. Individual data, laboratory indices, imaging characteristics, and clinical data were collected, and statistical analysis was performed. Based on clinical typing results, the patients were divided into a progression group or an improvement/stabilization group. Continuous variables were analyzed using independent samples t-test or Mann-Whitney U test. Categorical variables were analyzed using Chi-squared test or Fisher exact test. Logistic regression analysis was performed to explore the risk factors for disease progression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Seventy-eight patients with COVID-19-induced pneumonia met the inclusion criteria and were included in this study. Efficacy evaluation at 2 weeks after hospitalization indicated that 11 patients (14.1%) had deteriorated, and 67 patients (85.9%) had improved/stabilized. The patients in the progression group were significantly older than those in the disease improvement/stabilization group (66 [51, 70] vs. 37 [32, 41] years, U = 4.932, P = 0.001). The progression group had a significantly higher proportion of patients with a history of smoking than the improvement/stabilization group (27.3% vs. 3.0%, χ = 9.291, P = 0.018). For all the 78 patients, fever was the most common initial symptom, and the maximum body temperature at admission was significantly higher in the progression group than in the improvement/stabilization group (38.2 [37.8, 38.6] vs. 37.5 [37.0, 38.4]°C, U = 2.057, P = 0.027). Moreover, the proportion of patients with respiratory failure (54.5% vs. 20.9%, χ = 5.611, P = 0.028) and respiratory rate (34 [18, 48] vs. 24 [16, 60] breaths/min, U = 4.030, P = 0.004) were significantly higher in the progression group than in the improvement/stabilization group. C-reactive protein was significantly elevated in the progression group compared to the improvement/stabilization group (38.9 [14.3, 64.8] vs. 10.6 [1.9, 33.1] mg/L, U = 1.315, P = 0.024). Albumin was significantly lower in the progression group than in the improvement/stabilization group (36.62 ± 6.60 vs. 41.27 ± 4.55 g/L, U = 2.843, P = 0.006). Patients in the progression group were more likely to receive high-level respiratory support than in the improvement/stabilization group (χ = 16.01, P = 0.001). Multivariate logistic analysis indicated that age (odds ratio [OR], 8.546; 95% confidence interval [CI]: 1.628-44.864; P = 0.011), history of smoking (OR, 14.285; 95% CI: 1.577-25.000; P = 0.018), maximum body temperature at admission (OR, 8.999; 95% CI: 1.036-78.147, P = 0.046), respiratory failure (OR, 8.772, 95% CI: 1.942-40.000; P = 0.016), albumin (OR, 7.353, 95% CI: 1.098-50.000; P = 0.003), and C-reactive protein (OR, 10.530; 95% CI: 1.224-34.701, P = 0.028) were risk factors for disease progression.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Several factors that led to the progression of COVID-19 pneumonia were identified, including age, history of smoking, maximum body temperature on admission, respiratory failure, albumin, C-reactive protein. These results can be used to further enhance the ability of management of COVID-19 pneumonia.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tao</LastName><ForeName>Zhao-Wu</ForeName><Initials>ZW</Initials><AffiliationInfo><Affiliation>Department of Respiratory Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lei</LastName><ForeName>Wang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ming-Li</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kui</LastName><ForeName>Liu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ling</LastName><ForeName>Zhou</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shuang</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Deng</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jing</LastName><ForeName>Liu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Radiology, Wuhan Pulmonary Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hui-Guo</ForeName><Initials>HG</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ming</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The Provost's Office, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yi</LastName><ForeName>Hu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin Med J (Engl)</MedlineTA><NlmUniqueID>7513795</NlmUniqueID><ISSNLinking>0366-6999</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32118640</ArticleId><ArticleId IdType="doi">10.1097/CM9.0000000000000775</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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