Dysregulation of immune response in patients with COVID-19 in Wuhan, China.
Identifieur interne : 000103 ( PubMed/Corpus ); précédent : 000102; suivant : 000104Dysregulation of immune response in patients with COVID-19 in Wuhan, China.
Auteurs : Chuan Qin ; Luoqi Zhou ; Ziwei Hu ; Shuoqi Zhang ; Sheng Yang ; Yu Tao ; Cuihong Xie ; Ke Ma ; Ke Shang ; Wei Wang ; Dai-Shi TianSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China.
DOI: 10.1093/cid/ciaa248
PubMed: 32161940
Links to Exploration step
pubmed:32161940Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dysregulation of immune response in patients with COVID-19 in Wuhan, China.</title><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Luoqi" sort="Zhou, Luoqi" uniqKey="Zhou L" first="Luoqi" last="Zhou">Luoqi Zhou</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Ziwei" sort="Hu, Ziwei" uniqKey="Hu Z" first="Ziwei" last="Hu">Ziwei Hu</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Shuoqi" sort="Zhang, Shuoqi" uniqKey="Zhang S" first="Shuoqi" last="Zhang">Shuoqi Zhang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Sheng" sort="Yang, Sheng" uniqKey="Yang S" first="Sheng" last="Yang">Sheng Yang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tao, Yu" sort="Tao, Yu" uniqKey="Tao Y" first="Yu" last="Tao">Yu Tao</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Cuihong" sort="Xie, Cuihong" uniqKey="Xie C" first="Cuihong" last="Xie">Cuihong Xie</name><affiliation><nlm:affiliation>Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Ke" sort="Ma, Ke" uniqKey="Ma K" first="Ke" last="Ma">Ke Ma</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shang, Ke" sort="Shang, Ke" uniqKey="Shang K" first="Ke" last="Shang">Ke Shang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tian, Dai Shi" sort="Tian, Dai Shi" uniqKey="Tian D" first="Dai-Shi" last="Tian">Dai-Shi Tian</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32161940</idno><idno type="pmid">32161940</idno><idno type="doi">10.1093/cid/ciaa248</idno><idno type="wicri:Area/PubMed/Corpus">000103</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000103</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dysregulation of immune response in patients with COVID-19 in Wuhan, China.</title><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Luoqi" sort="Zhou, Luoqi" uniqKey="Zhou L" first="Luoqi" last="Zhou">Luoqi Zhou</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Ziwei" sort="Hu, Ziwei" uniqKey="Hu Z" first="Ziwei" last="Hu">Ziwei Hu</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Shuoqi" sort="Zhang, Shuoqi" uniqKey="Zhang S" first="Shuoqi" last="Zhang">Shuoqi Zhang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Sheng" sort="Yang, Sheng" uniqKey="Yang S" first="Sheng" last="Yang">Sheng Yang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tao, Yu" sort="Tao, Yu" uniqKey="Tao Y" first="Yu" last="Tao">Yu Tao</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Cuihong" sort="Xie, Cuihong" uniqKey="Xie C" first="Cuihong" last="Xie">Cuihong Xie</name><affiliation><nlm:affiliation>Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Ke" sort="Ma, Ke" uniqKey="Ma K" first="Ke" last="Ma">Ke Ma</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shang, Ke" sort="Shang, Ke" uniqKey="Shang K" first="Ke" last="Shang">Ke Shang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tian, Dai Shi" sort="Tian, Dai Shi" uniqKey="Tian D" first="Dai-Shi" last="Tian">Dai-Shi Tian</name><affiliation><nlm:affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32161940</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>12</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Dysregulation of immune response in patients with COVID-19 in Wuhan, China.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa248</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa248</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February 12, 2020, were collected and analyzed. The data of laboratory examinations, including peripheral lymphocyte subsets, were analyzed and compared between severe and non-severe patients.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 452 patients with COVID-19 recruited, 286 were diagnosed as severe infection. The median age was 58 years and 235 were male. The most common symptoms were fever, shortness of breath, expectoration, fatigue, dry cough and myalgia. Severe cases tend to have lower lymphocytes counts, higher leukocytes counts and neutrophil-lymphocyte-ratio (NLR), as well as lower percentages of monocytes, eosinophils, and basophils. Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines. The number of T cells significantly decreased, and more hampered in severe cases. Both helper T cells and suppressor T cells in patients with COVID-19 were below normal levels, and lower level of helper T cells in severe group. The percentage of naïve helper T cells increased and memory helper T cells decreased in severe cases. Patients with COVID-19 also have lower level of regulatory T cells, and more obviously damaged in severe cases.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The novel coronavirus might mainly act on lymphocytes, especially T lymphocytes. Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Chuan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Luoqi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Ziwei</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Shuoqi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Sheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tao</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Cuihong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shang</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Dai-Shi</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Lymphocyte subsets</Keyword><Keyword MajorTopicYN="N">T lymphocyte</Keyword><Keyword MajorTopicYN="N">immune response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32161940</ArticleId><ArticleId IdType="pii">5803306</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa248</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000103 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000103 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:32161940
|texte= Dysregulation of immune response in patients with COVID-19 in Wuhan, China.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:32161940" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |