Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Identifieur interne : 000669 ( PubMed/Checkpoint ); précédent : 000668; suivant : 000670Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Auteurs : Krishnan Suresh Kumar [Inde] ; Swastika Ganguly ; Ravichandran Veerasamy ; Erik De ClercqSource :
- European journal of medicinal chemistry [ 1768-3254 ] ; 2010.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Bases de Schiff (), Humains, Lignée cellulaire, Quinazolines (), Quinazolines (pharmacologie), Quinazolines (synthèse chimique), Spectrophotométrie IR, Spectroscopie par résonance magnétique, Évaluation préclinique de médicament.
- MESH :
- pharmacologie : Antiviraux, Quinazolines.
- synthèse chimique : Antiviraux, Quinazolines.
- Antiviraux, Bases de Schiff, Humains, Lignée cellulaire, Quinazolines, Spectrophotométrie IR, Spectroscopie par résonance magnétique, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cell Line, Drug Evaluation, Preclinical, Humans, Magnetic Resonance Spectroscopy, Quinazolines (chemical synthesis), Quinazolines (chemistry), Quinazolines (pharmacology), Schiff Bases (chemistry), Spectrophotometry, Infrared.
- MESH :
- chemical , chemical synthesis : Antiviral Agents, Quinazolines.
- chemical , chemistry : Antiviral Agents, Quinazolines, Schiff Bases.
- chemical , pharmacology : Antiviral Agents, Quinazolines.
- Cell Line, Drug Evaluation, Preclinical, Humans, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared.
Abstract
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.
DOI: 10.1016/j.ejmech.2010.07.058
PubMed: 20724039
Affiliations:
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pubmed:20724039Le document en format XML
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<front><div type="abstract" xml:lang="en">A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.</div>
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<Abstract><AbstractText>A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.</AbstractText>
<CopyrightInformation>Crown Copyright © 2010. Published by Elsevier Masson SAS. All rights reserved.</CopyrightInformation>
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