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Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea.

Identifieur interne : 000634 ( PubMed/Checkpoint ); précédent : 000633; suivant : 000635

Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea.

Auteurs : Keren Yeshuroon-Koffler [Israël] ; Yonat Shemer-Avni ; Ayelet Keren-Naus ; Aviv D. Goldbart

Source :

RBID : pubmed:24574078

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English descriptors

Abstract

Early life viral infection is associated with neurogenic inflammation that is present in lymphoid tissues of the upper airway in children with obstructive sleep apnea (OSA). We hypothesized that viral genomic material is present in tonsils of children with OSA. Therefore, we examined tonsils for the presence of respiratory viruses' nucleic acids in children with OSA, and in children without OSA (undergoing surgery for recurrent throat infections (RI)).

DOI: 10.1002/ppul.23005
PubMed: 24574078


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pubmed:24574078

Le document en format XML

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<name sortKey="Yeshuroon Koffler, Keren" sort="Yeshuroon Koffler, Keren" uniqKey="Yeshuroon Koffler K" first="Keren" last="Yeshuroon-Koffler">Keren Yeshuroon-Koffler</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84101, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84101</wicri:regionArea>
<wicri:noRegion>84101</wicri:noRegion>
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<name sortKey="Shemer Avni, Yonat" sort="Shemer Avni, Yonat" uniqKey="Shemer Avni Y" first="Yonat" last="Shemer-Avni">Yonat Shemer-Avni</name>
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<name sortKey="Keren Naus, Ayelet" sort="Keren Naus, Ayelet" uniqKey="Keren Naus A" first="Ayelet" last="Keren-Naus">Ayelet Keren-Naus</name>
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<name sortKey="Goldbart, Aviv D" sort="Goldbart, Aviv D" uniqKey="Goldbart A" first="Aviv D" last="Goldbart">Aviv D. Goldbart</name>
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<nlm:affiliation>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84101, Israel.</nlm:affiliation>
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<term>Child</term>
<term>Child, Preschool</term>
<term>DNA, Viral (genetics)</term>
<term>Female</term>
<term>Humans</term>
<term>Hypertrophy</term>
<term>Male</term>
<term>Palatine Tonsil (pathology)</term>
<term>Palatine Tonsil (virology)</term>
<term>Polymerase Chain Reaction</term>
<term>RNA, Viral (genetics)</term>
<term>Sleep Apnea, Obstructive (surgery)</term>
<term>Tonsillectomy</term>
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<term>ADN viral (génétique)</term>
<term>ARN viral (génétique)</term>
<term>Amygdalectomie</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypertrophie</term>
<term>Mâle</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Syndrome d'apnées obstructives du sommeil ()</term>
<term>Tonsille palatine (anatomopathologie)</term>
<term>Tonsille palatine (virologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>DNA, Viral</term>
<term>RNA, Viral</term>
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<term>Tonsille palatine</term>
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<term>Palatine Tonsil</term>
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<term>Sleep Apnea, Obstructive</term>
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<term>Tonsille palatine</term>
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<term>Palatine Tonsil</term>
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<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Hypertrophy</term>
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<term>Femelle</term>
<term>Humains</term>
<term>Hypertrophie</term>
<term>Mâle</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Syndrome d'apnées obstructives du sommeil</term>
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<front>
<div type="abstract" xml:lang="en">Early life viral infection is associated with neurogenic inflammation that is present in lymphoid tissues of the upper airway in children with obstructive sleep apnea (OSA). We hypothesized that viral genomic material is present in tonsils of children with OSA. Therefore, we examined tonsils for the presence of respiratory viruses' nucleic acids in children with OSA, and in children without OSA (undergoing surgery for recurrent throat infections (RI)).</div>
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<Year>2016</Year>
<Month>03</Month>
<Day>31</Day>
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<Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
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<ISSN IssnType="Electronic">1099-0496</ISSN>
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<Volume>50</Volume>
<Issue>2</Issue>
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<Year>2015</Year>
<Month>Feb</Month>
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<Title>Pediatric pulmonology</Title>
<ISOAbbreviation>Pediatr. Pulmonol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Early life viral infection is associated with neurogenic inflammation that is present in lymphoid tissues of the upper airway in children with obstructive sleep apnea (OSA). We hypothesized that viral genomic material is present in tonsils of children with OSA. Therefore, we examined tonsils for the presence of respiratory viruses' nucleic acids in children with OSA, and in children without OSA (undergoing surgery for recurrent throat infections (RI)).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Tonsillar tissue from patients with OSA and RI was subjected to multiplex quantitative real time reverse transcription PCR (mqRTPCR), analyzed for the presence of common respiratory viruses' genetic material.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Fifty-six patients were included, of whom 34 had OSA (age (years ± S.D), 4.22 ± 1.14) and 22 with RI (4.35 ± 1.36). Respiratory viruses nucleic acids (24 detections) were observed in 17 (50%) OSA samples. In contrast, no virus was detected in RI samples (relative frequency P<0.0001). Viruses detected, based on frequency were Rhinovirus, Adenovirus, human metapneumovirus (hMPV), respiratory syncytial virus (RSV), and corona virus.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Respiratory viruses are detected in OSA hypertrophic tonsils, suggestive of their role in the evolution of tonsillar inflammation and hypertrophy. Early life viral infections may contribute to the pathogenesis of pediatric OSA.</AbstractText>
<CopyrightInformation>© 2014 Wiley Periodicals, Inc.</CopyrightInformation>
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