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Early Epidemiological and Clinical Characteristics of 28 Cases of Coronavirus Disease in South Korea

Identifieur interne : 000664 ( Pmc/Curation ); précédent : 000663; suivant : 000665

Early Epidemiological and Clinical Characteristics of 28 Cases of Coronavirus Disease in South Korea

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Source :

RBID : PMC:7045878

Abstract

Objectives

The first confirmed case of coronavirus disease 2019 (COVID-19) in South Korea was reported in January 2020, with 28 confirmed cases reported as of February 14th, 2020. The epidemiological and clinical characteristics of all 28 cases were analyzed in response to this disease.

Methods

The epidemiological characteristics and early clinical features of the 28 patients from Korea with confirmed COVID-19 were analyzed using COVID-19 reporting and surveillance data and the epidemiological investigation reports prepared by the rapid response team.

Results

There were 16 patients that entered Korea from foreign countries: Wuhan, China (11 patients), Zhuhai, China, (1 patient), Singapore (2 patients), Japan (1 patient), and Thailand (1 patient). The early symptoms were fever, sore throat, cough or sputum production, chills, and muscle ache. Three patients were asymptomatic, however, 18 developed pneumonia. Of the 28 cases, 16 were index cases imported from abroad, with 10 cases of secondary infection originating in Korea, and the route of transmission still under investigation for 2 patients. The 10 patients with secondary infection were infected from contact with family members or acquaintances of primary patients, and the suspected sites of transmission were mostly at home.

Conclusion

COVID-19 in Korea was spread by 16 infected individuals traveling from other countries, leading to second-generation cases. The initial symptoms were mostly minor, but the disease was infectious at this stage, resulting from close contact, particularly at home. Establishing an early detection strategy for COVID-19 is crucial for managing the transmission of the disease.


Url:
DOI: 10.24171/j.phrp.2020.11.1.03
PubMed: 32149037
PubMed Central: 7045878

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PMC:7045878

Le document en format XML

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<title xml:lang="en">Early Epidemiological and Clinical Characteristics of 28 Cases of Coronavirus Disease in South Korea</title>
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<title xml:lang="en" level="a" type="main">Early Epidemiological and Clinical Characteristics of 28 Cases of Coronavirus Disease in South Korea</title>
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<title level="j">Osong Public Health and Research Perspectives</title>
<idno type="ISSN">2210-9099</idno>
<idno type="eISSN">2233-6052</idno>
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<date when="2020">2020</date>
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<div type="abstract" xml:lang="en">
<sec>
<title>Objectives</title>
<p>The first confirmed case of coronavirus disease 2019 (COVID-19) in South Korea was reported in January 2020, with 28 confirmed cases reported as of February 14
<sup>th</sup>
, 2020. The epidemiological and clinical characteristics of all 28 cases were analyzed in response to this disease.</p>
</sec>
<sec>
<title>Methods</title>
<p>The epidemiological characteristics and early clinical features of the 28 patients from Korea with confirmed COVID-19 were analyzed using COVID-19 reporting and surveillance data and the epidemiological investigation reports prepared by the rapid response team.</p>
</sec>
<sec>
<title>Results</title>
<p>There were 16 patients that entered Korea from foreign countries: Wuhan, China (11 patients), Zhuhai, China, (1 patient), Singapore (2 patients), Japan (1 patient), and Thailand (1 patient). The early symptoms were fever, sore throat, cough or sputum production, chills, and muscle ache. Three patients were asymptomatic, however, 18 developed pneumonia. Of the 28 cases, 16 were index cases imported from abroad, with 10 cases of secondary infection originating in Korea, and the route of transmission still under investigation for 2 patients. The 10 patients with secondary infection were infected from contact with family members or acquaintances of primary patients, and the suspected sites of transmission were mostly at home.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>COVID-19 in Korea was spread by 16 infected individuals traveling from other countries, leading to second-generation cases. The initial symptoms were mostly minor, but the disease was infectious at this stage, resulting from close contact, particularly at home. Establishing an early detection strategy for COVID-19 is crucial for managing the transmission of the disease.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chen, N" uniqKey="Chen N">N Chen</name>
</author>
<author>
<name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author>
<name sortKey="Dong, X" uniqKey="Dong X">X Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author>
<name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author>
<name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author>
<name sortKey="Guan, X" uniqKey="Guan X">X Guan</name>
</author>
<author>
<name sortKey="Wu, P" uniqKey="Wu P">P Wu</name>
</author>
</analytic>
</biblStruct>
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<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Osong Public Health Res Perspect</journal-id>
<journal-id journal-id-type="iso-abbrev">Osong Public Health Res Perspect</journal-id>
<journal-id journal-id-type="publisher-id">kphrp1</journal-id>
<journal-title-group>
<journal-title>Osong Public Health and Research Perspectives</journal-title>
</journal-title-group>
<issn pub-type="ppub">2210-9099</issn>
<issn pub-type="epub">2233-6052</issn>
<publisher>
<publisher-name>Korea Centers for Disease Control and Prevention</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">32149037</article-id>
<article-id pub-id-type="pmc">7045878</article-id>
<article-id pub-id-type="doi">10.24171/j.phrp.2020.11.1.03</article-id>
<article-id pub-id-type="publisher-id">ophrp-11-8</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Early Epidemiological and Clinical Characteristics of 28 Cases of Coronavirus Disease in South Korea</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<collab>COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention</collab>
<xref rid="c1-ophrp-11-8" ref-type="corresp">*</xref>
</contrib>
<aff id="af1-ophrp-11-8">Korea Centers for Disease Control and Prevention, Cheongju, Korea</aff>
</contrib-group>
<author-notes>
<corresp id="c1-ophrp-11-8">
<label>*</label>
Corresponding author: COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention, Cheongju, Korea, E-mail:
<email>jeongek@korea.kr</email>
</corresp>
<fn id="fn1-ophrp-11-8">
<p>
<bold>COVID-19 National Emergency Response Center, Epidemiology and Case Management Team. 2020.2.14.</bold>
</p>
<p>
<underline>Center for Disease Prevention, KCDC</underline>
</p>
<p>Insik Kong, Youngjoon Park, Yeonhee Woo, Joosun Lee, Jeongok Cha, Junkil Choi, Youngman Kim, Jieun Kim, Shinyoung Park, Minwoo Yum, Taeyoung Kim, Joongho Jo.</p>
<p>
<underline>Center for Infectious Disease Control, KCDC</underline>
</p>
<p>Miyoung Kim, Donghan Lee, Jonghee Kim, Sookkyung Park, Hyunjung Bahk, Jeonghee Yu, Jeongran Kwon, Heesook Kim, Nari Shin, Sanghyuk Lee, Hyekyung In, Jangeun Jung, Seunghee Cho, Byounghak Jeon, Dongwook Kim.</p>
<p>
<underline>Center for Public Health Emergency Preparedness and Response, KCDC</underline>
</p>
<p>Gwack Jin, Seongsun Kim, Sungnam Kim, Youngki Kim, Eunyoung Kim, Byran Inho Kim, Heejung Kim, Hyeyoung Lee, Yeowon Jin, Jeonghyun Kim, Hwami Kim, Boyeong Ryu, Seunghwan Shin, Eensuk Shin, Jin Lee, Sangeun Lee, Yoonsuk Jang, Eunkyung Choi, Junghee Hyun, Daehyeon Ko, Garam Seo, Seunghwi Kwon, Eunmi Park, Seungwoo Choi.</p>
<p>
<underline>Center for Laboratory Control of Infectious Diseases, KCDC</underline>
</p>
<p>Seondo Hwang, Sangeun Lee, Byunghak Kang, Jaesun Park, Deogyong Lee, Sukyoung Jo, Siwon Choi.</p>
<p>
<underline>Center for Genome Science, KCDC</underline>
</p>
<p>Junghyun Lee, Sanghyun Cho, Jaekyung Park.</p>
<p>
<underline>Center for Organ Transplant Management, KCDC</underline>
</p>
<p>Junnyun Kim.</p>
<p>
<underline>National Center for Medical Information and Knowledge, KCDC</underline>
</p>
<p>Eungyu Lee, Jungsook Kim.</p>
<p>
<underline>Bureau of Planning & Coordination, KCDC</underline>
</p>
<p>Sunmi Kim.</p>
<p>
<underline>Bureau of Health Policy, Ministry of Health and Welfare, MOHW</underline>
</p>
<p>Unna Kim.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<month>2</month>
<year>2020</year>
</pub-date>
<volume>11</volume>
<issue>1</issue>
<fpage>8</fpage>
<lpage>14</lpage>
<history>
<date date-type="received">
<day>16</day>
<month>2</month>
<year>2020</year>
</date>
<date date-type="rev-recd">
<day>20</day>
<month>2</month>
<year>2020</year>
</date>
<date date-type="accepted">
<day>21</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright ©2020, Korea Centers for Disease Control and Prevention</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">
<license-p>
<pmc-comment>CREATIVE COMMONS</pmc-comment>
This is an open access article under the CC BY-NC-ND license (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Objectives</title>
<p>The first confirmed case of coronavirus disease 2019 (COVID-19) in South Korea was reported in January 2020, with 28 confirmed cases reported as of February 14
<sup>th</sup>
, 2020. The epidemiological and clinical characteristics of all 28 cases were analyzed in response to this disease.</p>
</sec>
<sec>
<title>Methods</title>
<p>The epidemiological characteristics and early clinical features of the 28 patients from Korea with confirmed COVID-19 were analyzed using COVID-19 reporting and surveillance data and the epidemiological investigation reports prepared by the rapid response team.</p>
</sec>
<sec>
<title>Results</title>
<p>There were 16 patients that entered Korea from foreign countries: Wuhan, China (11 patients), Zhuhai, China, (1 patient), Singapore (2 patients), Japan (1 patient), and Thailand (1 patient). The early symptoms were fever, sore throat, cough or sputum production, chills, and muscle ache. Three patients were asymptomatic, however, 18 developed pneumonia. Of the 28 cases, 16 were index cases imported from abroad, with 10 cases of secondary infection originating in Korea, and the route of transmission still under investigation for 2 patients. The 10 patients with secondary infection were infected from contact with family members or acquaintances of primary patients, and the suspected sites of transmission were mostly at home.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>COVID-19 in Korea was spread by 16 infected individuals traveling from other countries, leading to second-generation cases. The initial symptoms were mostly minor, but the disease was infectious at this stage, resulting from close contact, particularly at home. Establishing an early detection strategy for COVID-19 is crucial for managing the transmission of the disease.</p>
</sec>
</abstract>
<kwd-group>
<kwd>COVID-19</kwd>
<kwd>epidemiologic study</kwd>
<kwd>SARS-CoV-2</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group>
<fig id="f1-ophrp-11-8" orientation="portrait" position="float">
<label>Figure 1</label>
<caption>
<p>COVID-19 epidemic curve (onset of signs and symptoms).</p>
<p>COVID-19 = coronavirus disease 2019.</p>
</caption>
<graphic xlink:href="ophrp-11-8f1"></graphic>
</fig>
<fig id="f2-ophrp-11-8" orientation="portrait" position="float">
<label>Figure 2</label>
<caption>
<p>Transmission dynamics in cases of coronavirus disease.</p>
</caption>
<graphic xlink:href="ophrp-11-8f2"></graphic>
</fig>
<table-wrap id="t1-ophrp-11-8" orientation="portrait" position="float">
<label>Table 1</label>
<caption>
<p>Demographic characteristics of 28 COVID-19 patients in South Korea (
<italic>N</italic>
= 28).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th valign="bottom" align="left" rowspan="1" colspan="1">Variables</th>
<th valign="bottom" align="left" rowspan="1" colspan="1"></th>
<th valign="bottom" align="center" rowspan="1" colspan="1">
<italic>n</italic>
</th>
<th valign="bottom" align="right" rowspan="1" colspan="1">%</th>
</tr>
</thead>
<tbody>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Gender</td>
</tr>
<tr>
<td rowspan="2" valign="top" align="left" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Male</td>
<td valign="top" align="center" rowspan="1" colspan="1">15</td>
<td valign="top" align="right" rowspan="1" colspan="1">53.6</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1">Female</td>
<td valign="top" align="center" rowspan="1" colspan="1">13</td>
<td valign="top" align="right" rowspan="1" colspan="1">46.4</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Age (y)</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">20–29</td>
<td valign="top" align="center" rowspan="1" colspan="1">6</td>
<td valign="top" align="right" rowspan="1" colspan="1">21.4</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">30–39</td>
<td valign="top" align="center" rowspan="1" colspan="1">6</td>
<td valign="top" align="right" rowspan="1" colspan="1">21.4</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">40–49</td>
<td valign="top" align="center" rowspan="1" colspan="1">6</td>
<td valign="top" align="right" rowspan="1" colspan="1">21.4</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">50–59</td>
<td valign="top" align="center" rowspan="1" colspan="1">8</td>
<td valign="top" align="right" rowspan="1" colspan="1">28.6</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">60–69</td>
<td valign="top" align="center" rowspan="1" colspan="1">1</td>
<td valign="top" align="right" rowspan="1" colspan="1">3.6</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">70–79</td>
<td valign="top" align="center" rowspan="1" colspan="1">1</td>
<td valign="top" align="right" rowspan="1" colspan="1">3.6</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Nationality</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Korean</td>
<td valign="top" align="center" rowspan="1" colspan="1">22</td>
<td valign="top" align="right" rowspan="1" colspan="1">78.6</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1">Chinese</td>
<td valign="top" align="left" rowspan="1" colspan="1">6</td>
<td valign="top" align="center" rowspan="1" colspan="1">21.4</td>
<td valign="top" align="right" rowspan="1" colspan="1"></td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Signs and Symptoms at onset (may be duplicated)</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Fever</td>
<td valign="top" align="center" rowspan="1" colspan="1">9</td>
<td valign="top" align="right" rowspan="1" colspan="1">32.1</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Sore Throat</td>
<td valign="top" align="center" rowspan="1" colspan="1">9</td>
<td valign="top" align="right" rowspan="1" colspan="1">32.1</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Cough or Sputum</td>
<td valign="top" align="center" rowspan="1" colspan="1">5</td>
<td valign="top" align="right" rowspan="1" colspan="1">17.9</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Chills</td>
<td valign="top" align="center" rowspan="1" colspan="1">5</td>
<td valign="top" align="right" rowspan="1" colspan="1">17.9</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Muscle ache</td>
<td valign="top" align="center" rowspan="1" colspan="1">4</td>
<td valign="top" align="right" rowspan="1" colspan="1">14.3</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Generalized weakness</td>
<td valign="top" align="center" rowspan="1" colspan="1">3</td>
<td valign="top" align="right" rowspan="1" colspan="1">10.7</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Headache</td>
<td valign="top" align="center" rowspan="1" colspan="1">3</td>
<td valign="top" align="right" rowspan="1" colspan="1">10.7</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Asymptomatic infection or Unknown
<xref rid="tfn1-ophrp-11-8" ref-type="table-fn">*</xref>
</td>
<td valign="top" align="center" rowspan="1" colspan="1">3</td>
<td valign="top" align="right" rowspan="1" colspan="1">10.7</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Pneumonia after admission</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Pneumonia</td>
<td valign="top" align="center" rowspan="1" colspan="1">18</td>
<td valign="top" align="right" rowspan="1" colspan="1">64.3</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="tfn1-ophrp-11-8">
<label>*</label>
<p>Unknown: due to treatment with antibiotics and analgesics after surgery.</p>
</fn>
<fn id="tfn2-ophrp-11-8">
<p>COVID-19 = coronavirus disease 2019.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t2-ophrp-11-8" orientation="portrait" position="float">
<label>Table 2</label>
<caption>
<p>Epidemiological characteristics of 28 patients with COVID-19 in South Korea (
<italic>N</italic>
= 28).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th valign="bottom" align="left" rowspan="1" colspan="1">Source of infection</th>
<th valign="bottom" align="left" rowspan="1" colspan="1"></th>
<th valign="bottom" align="center" rowspan="1" colspan="1">
<italic>n</italic>
</th>
<th valign="bottom" align="right" rowspan="1" colspan="1">%</th>
</tr>
</thead>
<tbody>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Case imported</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Wuhan, China</td>
<td valign="top" align="center" rowspan="1" colspan="1">11</td>
<td valign="top" align="right" rowspan="1" colspan="1">68.8</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Zhuhai, China</td>
<td valign="top" align="center" rowspan="1" colspan="1">1</td>
<td valign="top" align="right" rowspan="1" colspan="1">6.3</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Japan</td>
<td valign="top" align="center" rowspan="1" colspan="1">1</td>
<td valign="top" align="right" rowspan="1" colspan="1">6.3</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Singapore</td>
<td valign="top" align="center" rowspan="1" colspan="1">2</td>
<td valign="top" align="right" rowspan="1" colspan="1">12.5</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Thailand</td>
<td valign="top" align="center" rowspan="1" colspan="1">1</td>
<td valign="top" align="right" rowspan="1" colspan="1">6.3</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Local transmission site</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Residence</td>
<td valign="top" align="center" rowspan="1" colspan="1">7</td>
<td valign="top" align="right" rowspan="1" colspan="1">70.0</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Outside residence</td>
<td valign="top" align="center" rowspan="1" colspan="1">3</td>
<td valign="top" align="right" rowspan="1" colspan="1">30.0</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Hospital</td>
<td valign="top" align="center" rowspan="1" colspan="1">-</td>
<td valign="top" align="right" rowspan="1" colspan="1">-</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Airplane</td>
<td valign="top" align="center" rowspan="1" colspan="1">-</td>
<td valign="top" align="right" rowspan="1" colspan="1">-</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td colspan="4" valign="top" align="left" rowspan="1">Relationship in local transmission</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Family</td>
<td valign="top" align="center" rowspan="1" colspan="1">5</td>
<td valign="top" align="right" rowspan="1" colspan="1">50.0</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Relatives</td>
<td valign="top" align="center" rowspan="1" colspan="1">2</td>
<td valign="top" align="right" rowspan="1" colspan="1">20.0</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Acquaintance</td>
<td valign="top" align="center" rowspan="1" colspan="1">3</td>
<td valign="top" align="right" rowspan="1" colspan="1">30.0</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1">Co-worker</td>
<td valign="top" align="center" rowspan="1" colspan="1">-</td>
<td valign="top" align="right" rowspan="1" colspan="1">-</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="center" rowspan="1" colspan="1">Mean ± SD</td>
<td valign="top" align="right" rowspan="1" colspan="1">Range</td>
</tr>
<tr>
<td colspan="4" valign="bottom" align="left" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="1" colspan="1">Incubation period
<xref rid="tfn3-ophrp-11-8" ref-type="table-fn">*</xref>
</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="center" rowspan="1" colspan="1">4.1 ± 1.85</td>
<td valign="top" align="right" rowspan="1" colspan="1">2–9</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="tfn3-ophrp-11-8">
<label>*</label>
<p>Local transmission
<italic>n</italic>
= 9 (except 1 with unknown onset date of symptoms).</p>
</fn>
<fn id="tfn4-ophrp-11-8">
<p>COVID-19 = coronavirus disease 2019.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>

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